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This study showed that spontaneous Lmx1a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
The data of this study that Oc-1 (show ONECUT1 Proteins) interacts with Lmx1a to promote ventral midbrain neural stem cells differentiation into dopamine neuron through Wnt1 (show WNT1 Proteins)-Lmx1a pathway.
Lmx1a signaling in mouse embryonic stem cells contributes to a molecular cascade establishing neuronal specification.
our data demonstrate that key midbrain dopamine regulators (Nurr1 (show NR4A2 Proteins), Pitx3 (show PITX3 Proteins), and Lmx1a) play overlapping as well as distinct roles during neurogenesis and neurotransmitter phenotype determination of mDA neurons
The data of this study suggested that aberrant anlage patterning and granule cell development lead to Purkinje cell ectopia, which ultimately causes abnormal cerebellar architecture in dreher.
dopamine transporter is a direct target of Lmx1a and emphasizes a novel role of Lmx1a as one of regulators of mature midbrain dopaminergic neurotransmitter phenotypes
Lmx1a mutant (dr/dr) embryos demonstrate a clear decrease in expression of the genes Grb10 (show GRB10 Proteins) and Rgs4 (show RGS4 Proteins).
The characterization of two new Lmx1a alleles highlights the critical role of this gene in the development of the cochlea and vestibular system.
Data conclude that Lmx1a is a useful marker for the extraction of progenitors of GABAergic or dopaminergic neurons.
The Lmx1a can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching.
Study revealed an anti-metastatic role of LMX1A in gastric cancer which is mediated by the negative regulation of beta-catenin (show CTNNB1 Proteins) signaling target genes.
Lmx1a and Lmx1b (show LMX1B Proteins) expression persists in mature dopaminergic neurons of the substantia nigra pars (show EPRS Proteins) compacta and the ventral tegmental area. [Review]
SNPs of the LMX1A gene might be associated with the susceptibility to congenital scoliosis and different clinical phenotypes in the Chinese Han population.
To our best knowledge, this is the first report demonstrating the application of TAT (show TAT Proteins)-LMX1A recombinant protein to enhance hESC differentiation to DA as shown by the expression of DA specific makers.
LMX1A is weakly methylated in cervical adenocarcinomas compared with controls, in a metastatic stage of cervical cancer.
these data imply that Sp1 (show PSG1 Proteins) and EZH2 (show EZH2 Proteins) may activate LMX1A expression upon oncogenic stress during cervical cancer development.
Higher immunostaining intensity for OPN (show SPP1 Proteins) and LMX1A correlated with WHO grades for meningiomas and some gliomas. Contrary to our expectations, LMX1A staining in WHO grade IV gliomas was shown to be weaker than in WHO grade III tumours.
One single nucleotide polymorphisms of lmx1a was strongly associated with the magnitude of training-related gains in verbal working memory
LMX1A may be a potential biomarker for gastric cancer.
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants.
LIM homeobox transcription factor 1-alpha
, LIM/homeobox protein 1.1
, LIM/homeobox protein LMX1A
, shaker short-tail