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These data will serve as a foundation for further insight into the cattle ADCY2 gene.
This study demonistrated that adcy2 knockout mice regulate the expression soluble adenylyl cyclase (show ADCY10 Proteins) in brain.
In patients receiving capecitabine monotherapy, rs4702484, located in ADCY2 and close to MTRR (show MTRR Proteins), was associated with slightly reduced PFS for homozygous wild-type patients (CC 6.2 vs. CT 8.0 months; P=0.018).
Our present study defines an AC2 cAMP signaling compartment that specifically regulates IL-6 (show IL6 Proteins) expression in bronchial smooth muscle cells.
AKAP79 (show AKAP5 Proteins), PKC (show PRRT2 Proteins), PKA and PDE4 (show PDE4A Proteins) participate in a Gq-linked muscarinic receptor (show CHRM5 Proteins) and adenylate cyclase 2 cAMP signalling complex.
AGS3 (show GPSM1 Proteins) reduced D(2L)DR-mediated sensitization of AC1 (show ADCY1 Proteins) and AC2.
A replication of association between two SNPs previously associated with COPD (show ARCN1 Proteins) (CHRNA3 (show CHRNA3 Proteins)/5 and IREB2 (show IREB2 Proteins)), as well as an association with COPD (show ARCN1 Proteins) of one locus initially associated with lung function (ADCY2).
Data suggest that SPARCL1, Shp2 (show PTPN11 Proteins), MSH2 (show MSH2 Proteins), E-cadherin (show CDH1 Proteins), p53 (show TP53 Proteins), ADCY-2 and MAPK (show MAPK1 Proteins) are potential prognostic markers in colorectal cancer.
AC2 and AC4 (show ADCY4 Proteins) isoforms, stimulated by GTP binding protein betagamma subunits, are expressed in bronchial nonlipid raft membrane fractions where they colocalize with and couple to prostanoid EP2 (show SPAG11B Proteins) receptors.
AC2 interacts with RXFP1 (show RXFP1 Proteins) through AKAP79 (show AKAP5 Proteins), whereas the association with PDE4D3 and PKA depends upon beta-arrestin 2 (show ARRB2 Proteins) binding to Ser704.
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.
adenylate cyclase 2
, adenylate cyclase 2 (brain)
, adenylate cyclase type 2
, adenylate cyclase type 2-like
, ATP pyrophosphate-lyase 2
, adenylate cyclase type II
, adenylyl cyclase 2
, 3',5'-cyclic AMP synthetase
, adenylate cyclase II
, type II adenylate cyclase
, mutant adenylate cyclase 2