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Sickle cell anemia patients carrying at least one allele of adcy6 rs3730070-G exhibited lower hemolytic rate than non-carriers in univariate analysis (p=0.006).
LRs are essential not only for the proper membrane distribution and maintenance of AC5/6 activity but also for the regulation of D1R- and D5R-mediated AC signaling.
Mutations in CNTNAP1 (show CNTNAP1 Proteins) and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects
AC6 localizes in lipid raft fractions of bronchial airway smooth muscle where it is stimulated by beta2 adrenergic- and prostacyclin receptors and inhibited by divalent calcium ions.
In addition to its direct effect on renin (show REN Proteins) gene transcription, PPARgamma (show PPARG Proteins) "sensitizes" renin (show REN Proteins) gene to cAMP via trans-activation of AC6 gene.
expression of nodular ADCY6, but not ADCY3 (show ADCY3 Proteins), was lower than the expression of both in perinodular tissue, which may be part of the mechanisms occurring in the hyperfunctioning nodules
Raf1 (show RAF1 Proteins) potentiates drug-stimulated cyclic AMP (show APRT Proteins) accumulation in cells expressing adenyl cyclcase 6 after activation of multiple signaling pathways.
A2bR (show ADORA2B Proteins) signals through adenylate cyclase (AC) 6 isoform in intestinal epithelial cells
AC6 overexpression in endothelial cells may have use as a means to enhance prostacyclin function and reduce endothelial barrier permeability.
Adenylyl cyclase V and adenylyl cyclase VI interacts with A-kinase anchoring protein 79 (AKAP79 (show AKAP5 Proteins)) in a complex that associates with protein kinase A forming a negative feedback loop that termporally regulates cAMP production.
GluN2B (show GRIN2B Proteins)-dependent calcium signaling and excitatory postsynaptic current, long-term depression, and spatial reversal learning are enhanced in the hippocampus of AC6(-/-) mice without altering the gross anatomy of the brain
Expression level of AC6 is positively associated with HSF1 (show HSF1 Proteins) in heart failure.
The role of AC6 in beta-adrenoceptor signalling in murine airways
Pkd1 (show PKD1 Proteins)(RC/RC) mice experience hepatic hypertrophy that can be corrected by pasireotide through a pathway involving AC6 and cAMP
AC6 in the proximal tubule modulates cAMP formation, Npt2a trafficking, and urinary phosphate excretion, which are highlighted by renal phosphate wasting in AC6(-/-) mice
Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle, contributing to colonic dysmotility during inflammation.
data indicate that AC6 plays a role in loading-induced bone adaptation, and these findings are consistent with our previous studies implicating primary cilia and AC6 in a novel mechanism of osteocyte mechanotransduction
AC6 is a key mediator of cyst formation and renal injury in a model of PKD (show PRKD1 Proteins).
Adenylyl cyclase 6 mediates the action of cyclic AMP (show TMPRSS5 Proteins)-dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation.
AC6 plays a key role in negative regulation of TLR4 (show TLR4 Proteins) signaling by promoting protein degradation. AC6 activation shifts TLR4 (show TLR4 Proteins) to lipid raft-mediated endocytosis, accelerating its degradation & suppressing downstream signaling.
co-localization of multiple signaling components in lipid rafts provides key spatial regulation of AC6 (ADCY6) activity.
This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors\; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.
adenylate cyclase 6
, adenylate cyclase type VI
, adenylyl cyclase type VI
, adenylate cyclase 6-like
, adenylate cyclase type 6-like
, ATP pyrophosphate-lyase 6
, adenylate cyclase type 6
, adenylyl cyclase 6
, ca(2+)-inhibitable adenylyl cyclase