Browse our ADCY6 Proteins (ADCY6)

Full name:
Adenylate Cyclase 6 Proteins (ADCY6)
On are 14 Adenylate Cyclase 6 (ADCY6) Proteins from 5 different suppliers available. Additionally we are shipping ADCY6 Antibodies (42) and ADCY6 Kits (3) and many more products for this protein. A total of 62 ADCY6 products are currently listed.
AC6, ACVI, adcy6, ADCYB, mKIAA0422
list all proteins Gene Name GeneID UniProt
ADCY6 112 O43306
ADCY6 11512 Q01341
ADCY6 25289  

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ADCY6 Proteins (ADCY6) by Origin

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Human Adenylate Cyclase 6 (ADCY6) interaction partners

  1. Sickle cell anemia patients carrying at least one allele of adcy6 rs3730070-G exhibited lower hemolytic rate than non-carriers in univariate analysis (p=0.006).

  2. LRs are essential not only for the proper membrane distribution and maintenance of AC5/6 activity but also for the regulation of D1R- and D5R-mediated AC signaling.

  3. Mutations in CNTNAP1 (show CNTNAP1 Proteins) and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects

  4. AC6 localizes in lipid raft fractions of bronchial airway smooth muscle where it is stimulated by beta2 adrenergic- and prostacyclin receptors and inhibited by divalent calcium ions.

  5. In addition to its direct effect on renin (show REN Proteins) gene transcription, PPARgamma (show PPARG Proteins) "sensitizes" renin (show REN Proteins) gene to cAMP via trans-activation of AC6 gene.

  6. expression of nodular ADCY6, but not ADCY3 (show ADCY3 Proteins), was lower than the expression of both in perinodular tissue, which may be part of the mechanisms occurring in the hyperfunctioning nodules

  7. Raf1 (show RAF1 Proteins) potentiates drug-stimulated cyclic AMP (show APRT Proteins) accumulation in cells expressing adenyl cyclcase 6 after activation of multiple signaling pathways.

  8. A2bR (show ADORA2B Proteins) signals through adenylate cyclase (AC) 6 isoform in intestinal epithelial cells

  9. AC6 overexpression in endothelial cells may have use as a means to enhance prostacyclin function and reduce endothelial barrier permeability.

  10. Adenylyl cyclase V and adenylyl cyclase VI interacts with A-kinase anchoring protein 79 (AKAP79 (show AKAP5 Proteins)) in a complex that associates with protein kinase A forming a negative feedback loop that termporally regulates cAMP production.

Mouse (Murine) Adenylate Cyclase 6 (ADCY6) interaction partners

  1. GluN2B (show GRIN2B Proteins)-dependent calcium signaling and excitatory postsynaptic current, long-term depression, and spatial reversal learning are enhanced in the hippocampus of AC6(-/-) mice without altering the gross anatomy of the brain

  2. Expression level of AC6 is positively associated with HSF1 (show HSF1 Proteins) in heart failure.

  3. The role of AC6 in beta-adrenoceptor signalling in murine airways

  4. Pkd1 (show PKD1 Proteins)(RC/RC) mice experience hepatic hypertrophy that can be corrected by pasireotide through a pathway involving AC6 and cAMP

  5. AC6 in the proximal tubule modulates cAMP formation, Npt2a (show SLC34A1 Proteins) trafficking, and urinary phosphate excretion, which are highlighted by renal phosphate wasting in AC6(-/-) mice

  6. Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle, contributing to colonic dysmotility during inflammation.

  7. data indicate that AC6 plays a role in loading-induced bone adaptation, and these findings are consistent with our previous studies implicating primary cilia and AC6 in a novel mechanism of osteocyte mechanotransduction

  8. AC6 is a key mediator of cyst formation and renal injury in a model of PKD (show PRKD1 Proteins).

  9. Adenylyl cyclase 6 mediates the action of cyclic AMP (show TMPRSS5 Proteins)-dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation.

  10. AC6 plays a key role in negative regulation of TLR4 (show TLR4 Proteins) signaling by promoting protein degradation. AC6 activation shifts TLR4 (show TLR4 Proteins) to lipid raft-mediated endocytosis, accelerating its degradation & suppressing downstream signaling.

Cow (Bovine) Adenylate Cyclase 6 (ADCY6) interaction partners

  1. co-localization of multiple signaling components in lipid rafts provides key spatial regulation of AC6 (ADCY6) activity.

ADCY6 Protein Profile

Protein Summary

This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors\; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.

Alternative names and synonyms associated with ADCY6

  • adenylate cyclase 6 (adcy6)
  • adenylate cyclase 6 (ADCY6)
  • adenylate cyclase 6a (adcy6a)
  • adenylate cyclase 6 (Adcy6)
  • AC6 protein
  • ACVI protein
  • adcy6 protein
  • ADCYB protein
  • mKIAA0422 protein

Protein level used designations for Adenylate Cyclase 6 Proteins (ADCY6)

adenylate cyclase 6 , adenylate cyclase type VI , adenylyl cyclase type VI , adenylate cyclase 6-like , adenylate cyclase type 6-like , ATP pyrophosphate-lyase 6 , adenylate cyclase type 6 , adenylyl cyclase 6 , ca(2+)-inhibitable adenylyl cyclase

414728 Xenopus laevis
451866 Pan troglodytes
570652 Danio rerio
100051295 Equus caballus
100354934 Oryctolagus cuniculus
100438178 Pongo abelii
100493933 Xenopus (Silurana) tropicalis
112 Homo sapiens
11512 Mus musculus
25289 Rattus norvegicus
477625 Canis lupus familiaris
509936 Bos taurus
100522613 Sus scrofa
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