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Data suggest that activation of adenosine A1 receptors elicit receptor-operated Ca(2+) entry in porcine afferent arterioles, the level of which is dependent on postnatal maturation of TRPC3 channels.
mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B ELISA Kits)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B ELISA Kits)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells
Mutation in ADORA1 may be associated with early-onset parkinsonism and cognitive dysfunction.
This study showed that increased neuronal A1R expression in Rasmussen Encephalitis may be involved in prevention of seizures spread and seizures-induced damage, limitation of both seizures and inflammation atrophy in 1 cerebral hemisphere.
A1R signaling enhances A2AR (show ADORA2A ELISA Kits)-mediated neurodegeneration [review]
Mutational and computational analysis of A1-AR revealed a distinct conformation of the second extracellular loop and a wider extracellular cavity with a secondary binding pocket that can accommodate orthosteric and allosteric ligands.
this study highlights a key role for extracellular loop 2 in A1AR orthosteric ligand binding and receptor activation.
Dysregulation in ADORA1/ADORA2A (show ADORA2A ELISA Kits) expression was associated with glioma development.
A1R mRNA levels and A1R density in PBMCs from idiopathic normal-pressure hydrocephalus patients were significantly lower than control subjects
In postmortem human prefrontal cortex, adenosine A1 receptor is coupled preferentially, if not exclusively, to Galphai-3.
Results show that ADORA1 rs2228079 and ADORA2A (show ADORA2A ELISA Kits) rs5751876 polymorphisms are associated with the risk of Gilles de la Tourette Syndrome, co-morbid disorders, and may affect the age of tics onset in Polish population.
It has the intrinsic ability to form a heteromeric complex with metabotropic glutamate (show GRIN1 ELISA Kits) receptor type 1 and mutually modulate signaling.
The three receptor sets considered (mAChR (show CHRM3 ELISA Kits), AR and TrkB (show NTRK2 ELISA Kits) receptors) intervene in modulating the conditions of the competition between nerve endings.
Systemic inflammatory response syndrome-associated lymphopenia is initiated by A1R desensitization and adenosine-mediated inhibition of IL-15 (show IL15 ELISA Kits) production is part of the mechanism that accounts for the delay in leukopenia recovery in patients with severe sepsis.
Results demonstrated a significant downregulation of adenosine A1 receptors in the cortex and striatum, concomitant to striatal D2R (show DRD2 ELISA Kits) downregulation in iron deficient mice and rats.
Adenosine A1A receptor and adenosine A3A receptor agonists and adenosine 5'-monophosphate cause regulated hypothermia that was characterized by a drop in total energy expenditure, physical inactivity, and preference for cooler environmental temperatures, indicating a reduced body temperature set point.
over-expression of sEH (show EPHX2 ELISA Kits) enhances A1AR-dependent contraction and reduces KATP channel-dependent relaxation in MAs (show MAS1 ELISA Kits). These results suggest a possible interaction between sEH (show EPHX2 ELISA Kits), A1AR, and KATP channels in regulating vascular tone.
Results indicate that the adenosine A1 receptor is an important molecular component mediating hypoxic depression in adult mice and it appears to stabilize respiration of neonatal mice
The findings of this study implicated a glial-neuronal circuit, mediated by Ado (show ADO ELISA Kits), neuronal AdoRA1, and glial AdK (show ADK ELISA Kits) that can modulate sleep homeostasis in a manner influenced by glial metabolic state.
Adenosine A1 receptor knockout mice displayed increased depressive-like behavior.
did not identify phenotypic modifications of A1AR-related effects on blood pressure, heart rate and plasma renin (show REN ELISA Kits) by differences in genetic background
NPS (show NPS ELISA Kits) evokes central antinociceptive effects by activating both A1 and A2A receptors during phase 1, but only the adenosine A2A receptor (show ADORA2A ELISA Kits) during phase 2 of the formalin test
Data suggest that that ADORA1 forms homomers/homodimers in brain cortex.
Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling.
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene.
adenosine A1 receptor
, A1 adenosine receptor
, adenosine receptor A1