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mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B ELISA Kits)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B ELISA Kits)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells
Mutational and computational analysis of A1-AR revealed a distinct conformation of the second extracellular loop and a wider extracellular cavity with a secondary binding pocket that can accommodate orthosteric and allosteric ligands.
this study highlights a key role for extracellular loop 2 in A1AR orthosteric ligand binding and receptor activation.
Dysregulation in ADORA1/ADORA2A (show ADORA2A ELISA Kits) expression was associated with glioma development.
A1R mRNA levels and A1R density in PBMCs from idiopathic normal-pressure hydrocephalus patients were significantly lower than control subjects
In postmortem human prefrontal cortex, adenosine A1 receptor is coupled preferentially, if not exclusively, to Galphai-3.
Results show that ADORA1 rs2228079 and ADORA2A (show ADORA2A ELISA Kits) rs5751876 polymorphisms are associated with the risk of Gilles de la Tourette Syndrome, co-morbid disorders, and may affect the age of tics onset in Polish population.
It has the intrinsic ability to form a heteromeric complex with metabotropic glutamate (show GRIN1 ELISA Kits) receptor type 1 and mutually modulate signaling.
Paeoniflorin promotes the survival of cultured cortical neurons by increasing Akt (show AKT1 ELISA Kits) and ERK1/2 (show MAPK1/3 ELISA Kits) phosphorylation via A1R-mediated transactivation of EGFR (show EGFR ELISA Kits).
Adenosine A1 receptor activation increases ENT1 (show SLC29A1 ELISA Kits) activity via protein kinase C (show PKC ELISA Kits).
This study revealed variation of regional A1AR availability associated with ADORA1 and particularly ADORA2A (show ADORA2A ELISA Kits) SNPs, several of which had previously been shown to be associated with increased anxiety and panic disorder.
over-expression of sEH (show EPHX2 ELISA Kits) enhances A1AR-dependent contraction and reduces KATP channel-dependent relaxation in MAs (show MAS1 ELISA Kits). These results suggest a possible interaction between sEH (show EPHX2 ELISA Kits), A1AR, and KATP channels in regulating vascular tone.
Results indicate that the adenosine A1 receptor is an important molecular component mediating hypoxic depression in adult mice and it appears to stabilize respiration of neonatal mice
The findings of this study implicated a glial-neuronal circuit, mediated by Ado (show ADO ELISA Kits), neuronal AdoRA1, and glial AdK (show ADK ELISA Kits) that can modulate sleep homeostasis in a manner influenced by glial metabolic state.
Adenosine A1 receptor knockout mice displayed increased depressive-like behavior.
did not identify phenotypic modifications of A1AR-related effects on blood pressure, heart rate and plasma renin (show REN ELISA Kits) by differences in genetic background
NPS (show NPS ELISA Kits) evokes central antinociceptive effects by activating both A1 and A2A receptors during phase 1, but only the adenosine A2A receptor (show ADORA2A ELISA Kits) during phase 2 of the formalin test
These findings indicate that adenosine activation of leukocyte adenosine A1 receptor plays a significant role in their recruitment to the infected lung and contributes to influenza pathogenesis.
The A1 adenosine receptor may play a role in the development of atherosclerosis
A1ARs mediate in utero caffeine effects on cardiac function and growth and that caffeine exposure leads to changes in DNA methylation (show HELLS ELISA Kits).
Adenosin inhibited Lipopolysaccharide-increased HIF1alpha (show HIF1A ELISA Kits) accumulation under both normoxic and hypoxic conditions, through activation of A1 and A3 adenosine receptors.
Data suggest that that ADORA1 forms homomers/homodimers in brain cortex.
Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling.
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene.
adenosine A1 receptor
, A1 adenosine receptor
, adenosine receptor A1