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Browse our Breast Cancer Anti-Estrogen Resistance 1 Proteins (BCAR1)

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Breast Cancer Anti-Estrogen Resistance 1 Proteins (BCAR1)
On are 7 Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) Proteins from 4 different suppliers available. Additionally we are shipping Breast Cancer Anti-Estrogen Resistance 1 Antibodies (176) and Breast Cancer Anti-Estrogen Resistance 1 Kits (20) and many more products for this protein. A total of 212 Breast Cancer Anti-Estrogen Resistance 1 products are currently listed.
AI385681, BCAR1, Cas, CAS1, CASS1, CRKAS, fc17f11, MGC68466, P130CAS, wu:fc17f11, zgc:175192
list all proteins Gene Name GeneID UniProt
BCAR1 9564 P56945
BCAR1 12927 Q61140
Rat BCAR1 BCAR1 25414 Q63767

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Breast Cancer Anti-Estrogen Resistance 1 Proteins (BCAR1) by Origin

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More Proteins for Breast Cancer Anti-Estrogen Resistance 1 Interaction Partners

Xenopus laevis Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) interaction partners

  1. bcar3 gene is expressed downstream of Gata2 (show GATA2 Proteins) during gastrulation, and is co-expressed with gata2 (show GATA2 Proteins) but is more broadly expressed during later development; its binding partner, bcar1 shows overlapping expression patterns

Human Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) interaction partners

  1. Tyrosine phosphorylation of focal adhesion kinase (FAK) and p130 (show RBL2 Proteins) Crk-associated substrate (CAS) was found to be correlated with pancreatic cancer cell invasiveness.

  2. Full-length and truncated p130Cas phosphorylated substrate domain molecules were expressed in breast cancer cells. Breast cancer cells expressing the full-length SD and the functional smaller SD fragment (spanning SD motifs 6-10) were injected into the mammary fat pads of mice. Both the complete and truncated SD significantly increased the occurrence of metastases to multiple organs.

  3. Elevated levels of p130Cas is associated with trastuzumab resistance in breast cancer.

  4. blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin (show PXN Proteins) are significantly expressed in individual cases.

  5. expression quantitative trait loci studies implicate BCAR1 as the causal gene of coronary artery disease Carotid intima-media thickness

  6. p130(Cas) exon 1 variants display altered functional properties; shorter 1B isoform exhibited diminished FAK (show PTK2 Proteins) binding activity + reduced cell migration + invasion; longest variant 1B1 exhibited the most efficient FAK (show PTK2 Proteins) binding + greatly enhanced migration

  7. these data identify a new p130Cas/Cyclooxygenase-2 (show PTGS2 Proteins) axis as a crucial element in the control of breast tumor plasticity.

  8. Data introduce hitherto unappreciated paradigms whereby reactive oxygen species can reciprocally regulate the cellular localization of pro- and anti-migratory signaling molecules, p130cas and PTEN, respectively.

  9. BCAR1 has a pivotal role in the regulation of tissue homeostasis in pathological conditions such as cancer. (Review)

  10. Cas promotes cell migration by linking actomyosin contractions to the adhesion complexes through interaction with Src and the actin cytoskeleton.

Mouse (Murine) Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) interaction partners

  1. reduction of p130Cas levels by siRNA affects process outgrowth, the thickness of cellular processes and migration behavior of Oli (show TOMM22 Proteins)-neu cells. long term p130Cas reduction results in increased apoptosis in cultured primary oligodendrocytes.

  2. CRP2 (show CEBPB Proteins) sequesters p130Cas at focal adhesions, thereby reducing lamellipodia formation and blunting vascular smooth muscle cell migration.

  3. p130Cas plays pivotal roles in osteoclastic bone resorption.

  4. 31-kDa caspase (show CASP3 Proteins)-generated cleavage product of p130Cas inhibited MyoD (show MYOD1 Proteins)-induced transcriptional activation of muscle-specific (show EIF3K Proteins) genes.

  5. beta1-Integrin signaling within migrating ganglion cell layer cells requires Cas (show CTNND1 Proteins) signaling-adaptor proteins

  6. Crk-associated substrate -vinculin (show VCL Proteins) binding significantly affects the dynamics of Crk-associated substrate and vinculin (show VCL Proteins) within focal adhesions as well as the size of focal adhesions.

  7. we provide evidence that exercise-induced p38 MAPK (show MAPK14 Proteins) signaling is not impaired by the muscle-specific (show EIF3K Proteins) deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skeletal muscle adaptation.

  8. study described a molecular complex of PTPalpha (show PTPRA Proteins)-BCAR3 (show BCAR3 Proteins)-Cas (show CTNND1 Proteins)-Src (show SRC Proteins); this complex forms in response to PTPalpha (show PTPRA Proteins) Tyr789 phosphorylation and mediates Cas (show CTNND1 Proteins) localization to focal adhesions and Cas (show CTNND1 Proteins) downstream signaling to promote cell migration

  9. p130Cas phosphorylation, mediated by integrin beta3, facilitates cofilin inactivation and promotes myogenic differentiation through modulating actin cytoskeleton remodelling

  10. Cas (show CTNND1 Proteins) is required for apoptosis that is induced by proteasome inhibition, and potentially by other death stimuli.

Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) Protein Profile

Protein Summary

BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006

Alternative names and synonyms associated with Breast Cancer Anti-Estrogen Resistance 1 (BCAR1)

  • breast cancer anti-estrogen resistance 1 (bcar1)
  • breast cancer anti-estrogen resistance 1 (BCAR1)
  • breast cancer anti-estrogen resistance 1 (Bcar1)
  • breast cancer anti-estrogen resistance 1-like (LOC100350323)
  • AI385681 protein
  • BCAR1 protein
  • Cas protein
  • CAS1 protein
  • CASS1 protein
  • CRKAS protein
  • fc17f11 protein
  • MGC68466 protein
  • P130CAS protein
  • wu:fc17f11 protein
  • zgc:175192 protein

Protein level used designations for BCAR1

breast cancer anti-estrogen resistance 1 , breast cancer anti-estrogen resistance protein 1-like , Cas scaffolding protein family member 1 , Crk-associated substrate p130Cas , breast cancer anti-estrogen resistance protein 1 , CRK-associated substrate , p130 Cas , p130cas , v-crk-associated tyrosine kinase substrate

398756 Xenopus laevis
415691 Gallus gallus
447979 Xenopus (Silurana) tropicalis
454246 Pan troglodytes
568309 Danio rerio
100391559 Callithrix jacchus
100435586 Pongo abelii
9564 Homo sapiens
12927 Mus musculus
25414 Rattus norvegicus
479648 Canis lupus familiaris
527550 Bos taurus
100127482 Sus scrofa
100350323 Oryctolagus cuniculus
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