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bcar3 gene is expressed downstream of Gata2 (show GATA2 Proteins) during gastrulation, and is co-expressed with gata2 (show GATA2 Proteins) but is more broadly expressed during later development; its binding partner, bcar1 shows overlapping expression patterns
blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin (show PXN Proteins) are significantly expressed in individual cases.
expression quantitative trait loci studies implicate BCAR1 as the causal gene of coronary artery disease Carotid intima-media thickness
p130(Cas) exon 1 variants display altered functional properties; shorter 1B isoform exhibited diminished FAK (show PTK2 Proteins) binding activity + reduced cell migration + invasion; longest variant 1B1 exhibited the most efficient FAK (show PTK2 Proteins) binding + greatly enhanced migration
these data identify a new p130Cas/Cyclooxygenase-2 (show PTGS2 Proteins) axis as a crucial element in the control of breast tumor plasticity.
Data introduce hitherto unappreciated paradigms whereby reactive oxygen species can reciprocally regulate the cellular localization of pro- and anti-migratory signaling molecules, p130cas and PTEN, respectively.
BCAR1 has a pivotal role in the regulation of tissue homeostasis in pathological conditions such as cancer. (Review)
Cas promotes cell migration by linking actomyosin contractions to the adhesion complexes through interaction with Src and the actin cytoskeleton.
Collectively, these studies demonstrate that p130Cas acts as a bridging molecule between the Kaposi's sarcoma-associated herpesvirus-induced entry signal complex and the downstream trafficking signalosome in endothelial cells.
Our results show that endogenous Cul5 (show CUL5 Proteins) suppresses epithelial cell transformation by several pathways, including inhibition of Src (show SRC Proteins)-Cas (show CSE1L Proteins)-induced ruffling through SOCS6 (show SOCS6 Proteins)
Increased BCAR1 expression is associated with non-small cell lung cancer.
reduction of p130Cas levels by siRNA affects process outgrowth, the thickness of cellular processes and migration behavior of Oli (show TOMM22 Proteins)-neu cells. long term p130Cas reduction results in increased apoptosis in cultured primary oligodendrocytes.
CRP2 (show CEBPB Proteins) sequesters p130Cas at focal adhesions, thereby reducing lamellipodia formation and blunting vascular smooth muscle cell migration.
p130Cas plays pivotal roles in osteoclastic bone resorption.
31-kDa caspase (show CASP3 Proteins)-generated cleavage product of p130Cas inhibited MyoD (show MYOD1 Proteins)-induced transcriptional activation of muscle-specific (show EIF3K Proteins) genes.
beta1-Integrin signaling within migrating ganglion cell layer cells requires Cas (show CTNND1 Proteins) signaling-adaptor proteins
Crk-associated substrate -vinculin (show VCL Proteins) binding significantly affects the dynamics of Crk-associated substrate and vinculin (show VCL Proteins) within focal adhesions as well as the size of focal adhesions.
we provide evidence that exercise-induced p38 MAPK (show MAPK14 Proteins) signaling is not impaired by the muscle-specific (show EIF3K Proteins) deletion of p130Cas. We conclude that p130Cas plays a limited role in mechanical-stress-induced skeletal muscle adaptation.
study described a molecular complex of PTPalpha (show PTPRA Proteins)-BCAR3 (show BCAR3 Proteins)-Cas (show CTNND1 Proteins)-Src (show SRC Proteins); this complex forms in response to PTPalpha (show PTPRA Proteins) Tyr789 phosphorylation and mediates Cas (show CTNND1 Proteins) localization to focal adhesions and Cas (show CTNND1 Proteins) downstream signaling to promote cell migration
p130Cas phosphorylation, mediated by integrin beta3, facilitates cofilin inactivation and promotes myogenic differentiation through modulating actin cytoskeleton remodelling
Cas (show CTNND1 Proteins) is required for apoptosis that is induced by proteasome inhibition, and potentially by other death stimuli.
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006
breast cancer anti-estrogen resistance 1
, breast cancer anti-estrogen resistance protein 1-like
, Cas scaffolding protein family member 1
, Crk-associated substrate p130Cas
, breast cancer anti-estrogen resistance protein 1
, CRK-associated substrate
, p130 Cas
, v-crk-associated tyrosine kinase substrate