Browse our CBLC Proteins (CBLC)

Full name:
Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C Proteins (CBLC)
On are 5 Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C (CBLC) Proteins from 4 different suppliers available. Additionally we are shipping CBLC Antibodies (57) and CBLC Kits (2) and many more products for this protein. A total of 67 CBLC products are currently listed.
2310076I21Rik, 2310079L19Rik, CBL-3, CBL-SL, Cbl3, RNF57
list all proteins Gene Name GeneID UniProt
Rat CBLC CBLC 292699  
CBLC 80794 Q80XL1
CBLC 23624 Q9ULV8

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Mouse (Murine) Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C (CBLC) interaction partners

  1. only the SH3 domains of CD2AP (show Cd2ap Proteins) are necessary to enhance the E3 ligase activity of Cbl-3/c toward Ret51 (show RET Proteins)

  2. Accumulation of c-Cbl (show CBL Proteins) and rapid termination of colony-stimulating factor 1 receptor (show CSF1R Proteins) signaling in interferon consensus sequence binding protein (show IRF8 Proteins)-deficient bone marrow-derived macrophages

  3. Results describe the detailed expression pattern of murine Cbl-3 and report the generation and characterization of Cbl-3-deficient mice.

  4. c-Cbl (show CBL Proteins) deficiency did not affect Fc epsilon RI-induced histamine release or total cellular protein phosphorylation. Its absence increased ERK (show EPHB2 Proteins) phosphorylation after receptor stimulation, but resulted in reduced p38 (show CRK Proteins) phosphorylation & Ca(2 (show CA2 Proteins)+) response.

  5. MMTV-CBLC transgenic mice show abnormal mammary gland development

Human Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C (CBLC) interaction partners

  1. Data suggest that ubiquitin ligase CBLC controls mostly network organization of the Golgi Apparatus.

  2. Silencing of CBLC causes increased sensitivity to PARP1 (show PARP1 Proteins) inhibitor olaparib in breast cancer cell line models and that defective homologous recombination (HR) DNA repair is the likely cause.

  3. the effects of two pathogenic missense mutations on the the catalytic activities of the human B12 (show NDUFB3 Proteins)-processing chaperone CblC

  4. This retrospective multicentre study evaluates clinical, biochemical and genetic findings in 88 cblC patients

  5. The ubiquitin ligase activity of Cbl (show CBL Proteins)-c by the direct interaction of the LIM (show PDLIM5 Proteins) zinc coordinating domain of Hic5 (show TGFB1I1 Proteins) is demonstrated.

  6. the N terminus of Cbl (show CBL Proteins)-c contributes to the binding to the E2 and phosphorylation of Tyr (show TYR Proteins)-341 leads to a decrease in affinity and an increase in the E3 activity of Cbl (show CBL Proteins)-c

  7. Data demonstrate that two E3 ligases of different classes, CBLC and AIP4 (show ITCH Proteins), can interact and cooperate to down-regulate EGFR (show EGFR Proteins) signaling.

  8. c-Cbl is a negative regulator of hepatocyte growth factor/receptor tyrosine kinase Met signaling in B cells, mediating ubiquitination and, consequently, proteosomal degradation of Met, with a role in Met-mediated tumorigenesis.

  9. Src (show SRC Proteins) is a preferential target of Cbl (show CBL Proteins)-c for degradation

  10. ubiquitin protein ligase (show UBE2K Proteins) activity is regulated in c-Cbl (show CBL Proteins) by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate (show GRIN1 Proteins) point mutations

CBLC Protein Profile

Protein Summary

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with CBLC

  • Cbl proto-oncogene C, E3 ubiquitin protein ligase (Cblc)
  • Casitas B-lineage lymphoma c (Cblc)
  • Cbl proto-oncogene C, E3 ubiquitin protein ligase (CBLC)
  • 2310076I21Rik protein
  • 2310079L19Rik protein
  • CBL-3 protein
  • CBL-SL protein
  • Cbl3 protein
  • RNF57 protein

Protein level used designations for CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c , Casitas B-lineage lymphoma c , Cbl proto-oncogene, E3 ubiquitin protein ligase C , CBL-3 , SH3-binding protein CBL-3 , SH3-binding protein CBL-C , signal transduction protein CBL-C , Cas-Br-M (murine) ectropic retroviral transforming sequence c , RING finger protein 57

292699 Rattus norvegicus
80794 Mus musculus
23624 Homo sapiens
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