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Results strongly suggest that a deficiency of Diacylglycerol kinase delta induces obsessive-compulsive disorder-like behavior through enhancing axon/neurite outgrowth in the brain.
DGKdelta deficiency impairs AMPK (show PRKAA1 Antibodies) signaling and lipid metabolism, thereby highlighting the deleterious role of excessive lipid metabolites in the development of peripheral insulin (show INS Antibodies) resistance and type 2 diabetes pathogenesis.
DGKD (show DGKQ Antibodies) preferably metabolizes palmitic acid-containing diacylglycerol species supplied from the PC-PLC (show HSPG2 Antibodies) pathway.
DGKdelta markedly increases lipid synthesis, at least in part as a result of promoting the synthesis of fatty acids.
These results suggest that DGKzeta (show DGKZ Antibodies) is involved in IQGAP1 (show IQGAP1 Antibodies)/Rac1-mediated phagocytosis upon LPS (show TLR4 Antibodies) stimulation in macrophages.
Results suggest that diacylglycerol kinase delta regulates epidermal growth factor (show EGF Antibodies) receptors by modulating protein kinase C (show PKC Antibodies) signaling.
Metabolic flexibility, evident by the transition between lipid and carbohydrate ut (show DGUOK Antibodies)ilization during fasted and fed conditions, was impaired in DGKdelta haploinsufficient mice.
Diacylglycerol signaling limits Akt (show AKT1 Antibodies) activation through diacylglycerol kinase delta and PHLPP2 (show PHLPP2 Antibodies).
This study demonistrated that the lack of association of DGKD SNPs with PD in the Han Chinese population.
Zinc site mutations impair DGKdelta localization to cytoplasmic puncta and enhance localization the plasma membrane.
Data indicate a novel mechanism where diacylglycerol kinase delta and protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies) modulate the levels of ubiquitinated epidermal growth factor (show EGF Antibodies) receptors through Akt (show AKT1 Antibodies) and ubiquitin-specific protease 8 (show USP8 Antibodies).
Disruption of diacylglycerol kinase delta (DGKD) is associated with seizures in humans and mice.
Study identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK (show DGKB Antibodies) activity in skeletal muscle from type 2 diabetic patients.
Polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location.
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.
diacylglycerol kinase, delta 130kDa
, diacylglycerol kinase delta-like
, DAG kinase delta
, diacylglycerol kinase delta
, diglyceride kinase delta