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anti-Human EPS8 Antibodies:
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Dog (Canine) Monoclonal EPS8 Primary Antibody for IF, IP - ABIN967774
Burke, Schooler, Wiley: Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. in Molecular biology of the cell 2001
Show all 4 references for ABIN967774
Human Polyclonal EPS8 Primary Antibody for IHC (p), IHC - ABIN268550
Fazioli, Minichiello, Matoska, Castagnino, Miki, Wong, Di Fiore: Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals. in The EMBO journal 1993
Cow (Bovine) Polyclonal EPS8 Primary Antibody for IHC, WB - ABIN2785852
Welsch, Endlich, Giese, Büchler, Schmidt: Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization. in Cancer letters 2007
Human Polyclonal EPS8 Primary Antibody for EIA, IHC (p) - ABIN360658
Wong, Carlomagno, Druck, Barletta, Croce, Huebner, Kraus, Di Fiore: Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24. in Oncogene 1994
Human Polyclonal EPS8 Primary Antibody for IHC (p), WB - ABIN392773
Nasr, Mukhopadhyay, Zhang, Katzenstein: Immunohistochemical markers in diagnosis of papillary thyroid carcinoma: Utility of HBME1 combined with CK19 immunostaining. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006
Immunohistochemistry revealed that Eps8 was significantly increased in cervical cancer specimens compared with squamous intraepithelial lesion and normal cervical tissues. Additionally, it was revealed that Eps8 expression not only correlated with cervical cancer progression, but also exhibited a close correlation with the epithelialmesenchymal transition (EMT (show ITK Antibodies)) markers, Ecadherin and vimentin (show VIM Antibodies).
Eps8 is required for continuous membrane blebbing.
Erk (show EPHB2 Antibodies) activity promotes actin bundling by Eps8 to enhance cortex tension and drive the bleb-based migration of cancer cells under non-adhesive confinement.
Eps8 is a crucial mediator of Src (show SRC Antibodies)- and FAK (show PTK2 Antibodies)-regulated processes.
Eps8 is overexpressed in human breast cancers, possibly by regulating ERK (show EPHB2 Antibodies) signaling, MMP9 (show MMP9 Antibodies), p53 (show TP53 Antibodies) and EMT (show ITK Antibodies)-like transition to affect breast cancer cell growth, migration and invasion.
EPS8, as MDR1 (show TBC1D9 Antibodies) and WT1 (show WT1 Antibodies), may be a clinically valuable biomarker for assessing the outcome of ALL patients.
These results indicate that employing the native and modified epitopes identified here in Eps8-based immunotherapy for HLA-A2.1 positive cancer patients may result in efficient anticancer immune responses for diverse tumor types.
determined the alpha-synuclein (show SNCA Antibodies)-binding domain of beta-III tubulin (show TUBB Antibodies) and demonstrated that a short fragment containing this domain can suppress alpha-synuclein (show SNCA Antibodies) accumulation in the primary cultured cells
The ITSN2 (show ITSN2 Antibodies) interacts with Eps8 and stimulates the degradation of Eps8 proteins.
EPS8 is an F-actin capping and bundling protein. Mutant mice lacking EPS8 (Eps8-/- mice), which is present in the hair bundle, the sensory antenna of the auditory sensory cells that operate the mechano-electrical transduction
These findings demonstrate a novel role for Wnt (show WNT2 Antibodies)-Dvl1 (show DVL1 Antibodies) signalling through Eps8 in the regulation of axonal remodeling.
It shows that EPS8, a signaling adapter regulating actin dynamics, is a novel partner of VE-cadherin (show CDH5 Antibodies) and is able to modulate YAP (show YAP1 Antibodies) activity.
The actin-binding proteins eps8 and gelsolin (show GSN Antibodies) have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.
These results reveal a previously unknown cell type-specific expression pattern of endogenous Eps8 protein in the mouse hippocampus.
the key role of Eps8 actin-capping activity in spine morphogenesis and plasticity and indicate that reductions in actin-capping proteins may characterize forms of intellectual disabilities associated with spine defects.
identified Eps8 as a unique actin capping protein (show TMOD4 Antibodies) specifically required for Dendritic cell migration
epidermal growth factor receptor pathway substrate 8 is critical in coordinating the development and functionality of mammalian auditory hair cells
critical role for JNK2 (show MAPK9 Antibodies) and EPS8 in receptor tyrosine kinase (show ERBB3 Antibodies) signaling and trafficking to convey distinctly different effects on cell migration.
It was concluded that MyoXVa, whirlin, and Eps8 are integral components of the stereocilia tip complex, where Eps8 is a central actin-regulatory element for elongation of the stereocilia actin core.
Eps8 has a role in preventing intestinal defects and improved metabolic status in mice
Coexpression of ezrin with Eps8 promotes the formation of membrane ruffles and tufts of microvilli, whereas expression of ezrin and Eps8L1a induces the clustering of actin-containing structures at the cell surface.
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
epidermal growth factor receptor pathway substrate 8
, epidermal growth factor receptor kinase substrate 8