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Human FBLN3 Protein expressed in Wheat germ - ABIN1352379
Hu, Pioli, Siegel, Zhang, Nelson, Chaturbedi, Mathews, Ro, Alkafeef, Hsu, Hamamura, Yu, Hess, Tromberg, Linskey, Zhou: EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment. in Molecular cancer 2011
Show all 2 references for ABIN1352379
Median FBLN-3 concentrations were 12.96.
The EFEMP1 gene is significantly down-regulated in leiomyoma compared with myometrium.
It was concluded that fibulin-3 is expressed at a lower level in colon cancer, and it can serve as a marker for advanced colon cancer.
Novel inguinal hernia susceptibility genes are identified as EFEMP1, WT1 (show WT1 Proteins), EBF2 (show EBF2 Proteins) and ADAMTS6 (show ADAMTS6 Proteins).
EFEMP1 might indirectly enhance the expression of MMP-2 (show MMP2 Proteins), providing a potential explanation for the role of AEG-1 (show MTDH Proteins) in metastasis. NF-kappaB (show NFKB1 Proteins) pathways might be one of the effective ways which EFEMP1 was induced by AEG-1 (show MTDH Proteins).
Suggest that FBLN-1 (show FBLN1 Proteins) may play a role in arterial stiffening in patients with atherosclerosis.
The polymorphisms of EFEMP1 gene were associated with breast cancer and might contribute to the susceptibility of the progression of breast cancer in Chinese Han women.
Studies indicate Arg345Trp (R345W) mutation in fibulin-3 (F3) as the cause of a rare retinal dystrophy (show MERTK Proteins), Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy (show MERTK Proteins) (ML/DHRD).
The recent finding that a common variant near EFEMP1 was associated with optic nerve-head morphology supports the possibility that the EFEMP1 variant identified in this Primary open-angle glaucoma family may be pathogenic.
restoring fibulin-3 expression in breast cancer cells inhibited TGF-beta (show TGFB1 Proteins) signaling, breast cancer cell EMT (show ITK Proteins), invasion and metastasis in vivo.
Define the Efemp1-p27(Kip1 (show CDKN1B Proteins)) axis as a potential marker module of PDAC cell sensitivity towards dual PI3K-mTOR (show FRAP1 Proteins) inhibitors.
The Efemp1 knock-in mice reconstitute the most important histopathologic symptoms of both Malattia leventinese and age-related macular degeneration.
fibulin-3 plays an important role in maintaining the integrity of fascia connective tissues and regulates aging.
both fibulin-3 and -5 are important in maintaining pelvic organ support in mice.
Data suggest a role for fibulin-3 in tissue maintenance and regeneration in the adult olfactory pathway.
This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.
EGF-containing fibulin-like extracellular matrix protein 1
, extracellular protein S1-5
, epidermal growth factor-containing fibulin-like extracellular matrix protein 1