Browse our PDE6H Proteins (PDE6H)

Full name:
phosphodiesterase 6H, CGMP-Specific, Cone, gamma Proteins (PDE6H)
On are 4 phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H) Proteins from 3 different suppliers available. Additionally we are shipping PDE6H Antibodies (18) and many more products for this protein. A total of 23 PDE6H products are currently listed.
A930033D18Rik, ACHM6, Pde6g, PDEgamma, RCD3
list all proteins Gene Name GeneID UniProt
PDE6H 5149 Q13956
PDE6H 78600 P61249
Rat PDE6H PDE6H 114248 P61250

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Human phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H) interaction partners

  1. These findings add PDE6H to the set of genes involved in autosomal-recessive cone disorders and demonstrate the importance of the inhibitory gamma subunit in cone phototransduction

  2. Our results indicate that mutations in the PDE6H gene are not common, because only 1 of 240 patients with cone dystrophy showed a single nucleotide substitution in the 5' UTR of PDE6H mRNA

Mouse (Murine) phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H) interaction partners

  1. Pde6h deficiency mice suggests no defects in cone/rod-driven retinal signaling and therefore preserved visual functions.

  2. The interdependency of phosphorylation of T22 and T35 suggests that light-induced, post-translational modification of PDE6gamma is essential for the regulation of G-protein signaling.

  3. Our results show that the PDE6gamma binding sites of PDE6 alpha and beta are accessible to excess (presumably cytoplasmic) PDE6gamma in the light, once endogenous PDE6gamma has been displaced from its binding site by Talpha-GTP (show AK3 Proteins).

  4. This experiments provide evidence for modulation of Pde6h dependent response turnoff in mouse rod photoreceptors.

PDE6H Protein Profile

Protein Summary

This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).

Alternative names and synonyms associated with PDE6H

  • phosphodiesterase 6H, cGMP-specific, cone, gamma (PDE6H)
  • phosphodiesterase 6H, cGMP-specific, cone, gamma (Pde6h)
  • A930033D18Rik protein
  • ACHM6 protein
  • Pde6g protein
  • PDEgamma protein
  • RCD3 protein

Protein level used designations for PDE6H

GMP-PDE gamma , retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma , cone phosphodiesterase 6 gamma , cone-like cGMP-phosphodiesterase 6 gamma subunit type 2 , phosphodiesterase 6G, cGMP-specific, rod, gamma

5149 Homo sapiens
281978 Bos taurus
78600 Mus musculus
114248 Rattus norvegicus
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