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Human PRKCE ELISA Kit for Sandwich ELISA - ABIN416792
Bailey, Bonasera, Wilderdyke, Hanisch, Pavlik, DeVasure, Robinson, Sisson, Wyatt: Aging causes a slowing in ciliary beat frequency, mediated by PKC?. in American journal of physiology. Lung cellular and molecular physiology 2014
PRKCE plays two major roles in cardiac muscle cells: it takes part in regulating cardiac muscle contraction via targeting the sarcomeric proteins, as well as it modulates cardiac cell energy production and metabolism by targeting cardiac mitochondria. (Review)
PKCepsilon is a key factor for driving the formation of bone metastasis by prostate cancer cells and is a potential therapeutic target for advanced stages of the disease.
Docosahexaenoic acid increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt (show AKT1 ELISA Kits) and PKCepsilon/delta-induced ERK (show EPHB2 ELISA Kits) pathways.
Depletion of PKCepsilon not only enhanced HGF-induced phosphorylation of JNK and paxillin (Ser178) but also prevented c-Met degradation.
miR (show MLXIP ELISA Kits)-34a regulates blood-tumor barrier (BTB) function by targeting PKCepsilon; after phosphorylation, PKCepsilon is activated and contributes to regulation of the expression of tight junction-related proteins, ultimately altering BTB permeability.
PKCepsilon-CREB (show CREB1 ELISA Kits)-Nrf2 (show GABPA ELISA Kits) signalling induces HO-1 (show HMOX1 ELISA Kits) in the vascular endothelium and enhances resistance to inflammation and apoptosis.
PKC-delta (show PKCd ELISA Kits) activates p38/MAPK (show MAPK14 ELISA Kits), responsible for the inhibition of MMP-2 (show MMP2 ELISA Kits) and -9 secretion, PKC-epsilon activates a pathway made of ERK1/2 (show MAPK1/3 ELISA Kits), mTOR (show FRAP1 ELISA Kits) and S6K (show RPS6KB1 ELISA Kits) responsible for the inhibition of NHE1 (show SLC9A1 ELISA Kits) activity and cell migration.
HepaCAM (show HEPACAM ELISA Kits) may prevent the translocation of PKCepsilon from cytosolic to particulate fractions, resulting in the inhibition of 786-0 cell proliferation.
Knockdown of PKCepsilon expression inhibited proliferation, induced apoptosis and decreased invasiveness of human glioma cell lines, and suppressed the growth of U87 cell-derived tumors in nude mice. PKCepsilon physically interacts with Stat3 (show STAT3 ELISA Kits).
PKCepsilon-mediated regulation has a role in protection from loss of chromosome integrity in cells failing to resolve catenation in G2
PKCepsilon signaling in both the nucleus accumbens and central nucleus of the amygdala is a major contributor to binge alcohol drinking and to the genetic propensity to consume excessive amounts of alcohol.
with strain there was significant PKCepsilon translocation to the Z-disc and co-localization with CapZbeta1 or alpha-actinin (show ACTN1 ELISA Kits), which was quantified on confocal images.
Protein kinase C epsilon phosphorylates the alpha4 nAChR (show CHRNA4 ELISA Kits) subunit and regulates recovery from receptor desensitization.
PKCepsilon-CREB (show CREB1 ELISA Kits)-Nrf2 (show NFE2L2 ELISA Kits) signalling induces HO-1 (show HMOX1 ELISA Kits) in the vascular endothelium and enhances resistance to inflammation and apoptosis.
acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.
PKCdelta (show PKCd ELISA Kits) and PKCepsilon have roles in restraining developmental and reactive heart growth
Pathway analysis indicated that monosaccharide metabolism was affected only upon PKCdelta (show PKCd ELISA Kits) deletion, while isoprenoid biosynthesis was affected in a PKCepsilon-specific manner.
Study demonstrates that PKCalpha (show PKCa ELISA Kits), PKCdelta (show PKCd ELISA Kits) and PKCepsilon isoforms are differentially expressed in particular cellular components of pre-pubertal, pubertal and adult mouse ovarian follicles.
data suggest a redundant role between members of the novel Protein Kinase C subfamily that allows for mutual compensation during mouse embryonic development, with vasculogenesis/angiogenesis as an obvious common function of these two Protein Kinase Cs.
PKCepsilon negatively interferes with vessel progenitor differentiation via interaction with PAK-1 (show PAK1 ELISA Kits)
These data identify PKCepsilon as a key regulator of cilia slowing in response to combined smoke and alcohol-induced lung injury.
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (show NOS3 ELISA Kits) post-translational modification
Differential expression of protein kinase C epsilon and an elevation of [Ca(2 (show CA2 ELISA Kits)+)]i are important for acquisition of luteolytic response to PGF2 alpha
By regulating VEGFR2 (show KDR ELISA Kits) expression and activation, PKC-epsilon expression is critical for activation of Akt (show AKT1 ELISA Kits) and eNOS (show NOS3 ELISA Kits) by VEGF (show VEGFA ELISA Kits) and contributes to VEGF (show VEGFA ELISA Kits)-stimulated Erk (show MAPK1 ELISA Kits) activation, whereas PKC-alpha (show PKCa ELISA Kits) has opposite effects.
Activation of PKC (show PKC ELISA Kits) induces the translocation of Nrf2 (show NFE2L2 ELISA Kits) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
in contrast to protective effects of PKC-epsilon activation in cardiomyocytes, sustained PKC-epsilon activation is detrimental to mitochondrial function and viability in renal proximal tubule cells
Preferential glucose utilization by PKCepsilon hearts is orchestrated by a p-GSK3beta/HIF-1alpha (show HIF1A ELISA Kits)-mediated mechanism.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
protein kinase C epsilon type
, protein kinase C, epsilon
, protein kinase C epsilon type-like
, pkc epsilon
, protein kinase C, eta