Browse our PTK2B Proteins (PTK2B)

Full name:
PTK2B Protein tyrosine Kinase 2 beta Proteins (PTK2B)
On www.antibodies-online.com are 14 PTK2B Protein tyrosine Kinase 2 beta (PTK2B) Proteins from 7 different suppliers available. Additionally we are shipping PTK2B Antibodies (257) and PTK2B Kits (21) and many more products for this protein. A total of 310 PTK2B products are currently listed.
Synonyms:
Akt, CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, FAK2, PKB, PKB/Akt, PKBalpha, PTK, Pyk2, Rac, Raftk
list all proteins Gene Name GeneID UniProt
PTK2B 24185 P47196
PTK2B 11651 P31750
PTK2B 2185 Q14289

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PTK2B Proteins (PTK2B) by Origin

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Mouse (Murine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. This work suggests that a switch in substrate specificity coupled to the phosphorylation status of Akt (show AKT1 Proteins) may lead to alternative cell fates and demonstrates that proteins involved with alternative splicing are important factors in T cell fate decisions.

  2. Suppression of Akt1 (show AKT1 Proteins)-beta-catenin (show CTNNB1 Proteins) pathway in advanced prostate cancer promotes TGFbeta1 (show TGFB1 Proteins)-mediated epithelial to mesenchymal transition and metastasis.

  3. TSC1 (show TSC1 Proteins)/TSC2 complex upregulation of OPN (show SPP1 Proteins) expression is mediated by transcription factor SOX9 (show SOX9 Proteins) in an mTOR (show FRAP1 Proteins)-independent manner. Moreover, ablation of OPN (show SPP1 Proteins) by deficient TSC1 (show TSC1 Proteins)/TSC2 complex contributed to inactivation of AKT (show AKT1 Proteins) in TSC (show SLC12A3 Proteins) cells

  4. Our results suggest that increasing Akt (show AKT1 Proteins)/ NF-kappaB (show NFKB1 Proteins) is a crucial mediator of skin aging, which can increase the susceptibility of cell transformation.

  5. findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.

  6. Studies indicate that the Pten+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten is a key regulatory player in the PI3K/PTEN/AKT (show AKT1 Proteins) pathway.

  7. a simple, linear, four-compartment ordinary differential equation (ODE) model of Akt (show AKT1 Proteins) activation that tracks both the biochemical state and the physical location of Akt (show AKT1 Proteins), is reported.

  8. Psgl-1 (show SELPLG Proteins) deficiency accelerates bleomycin-induced lung fibrosis and inflammation in mice through activating the PI3K/AKT (show AKT1 Proteins) axis.

  9. Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (show HSP90 Proteins) and the PI3K/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathway in prostate cancer.

  10. results show that Pyk2 contributes to cytotoxic T lymphocyte(CTL) migration by regulating detachment of CTL at the trailing edge, which could explain why Pyk2 is important for chemotactic and migratory responses.

Human PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (show CTNNB1 Proteins) in the crosstalk between Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and Wnt (show WNT2 Proteins)/Ca(2 (show CA2 Proteins)+) signaling pathways upon Wnt3a (show WNT3A Proteins) stimulation in differentiating hNPCs.

  2. STIM1 (show STIM1 Proteins)-induced Ca(2 (show CA2 Proteins)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (show PTPRB Proteins) and VE-cadherin (show CDH5 Proteins) and hence increase endothelial permeability.

  3. Ascites and CCL18 (show CCL18 Proteins) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.

  4. We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (show PIK3CA Proteins)-Akt/PKB (show AKT1 Proteins) cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.

  5. PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.

  6. Studies suggest that PYK2 is a common downstream effector of ErbB (show EGFR Proteins) and IL8 (show IL8 Proteins) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.

  7. Pyk2 is a key downstream signaling molecules of CCR7 (show CCR7 Proteins) in SCCHN, which promotes SCCHN tumorigenesis and progression.

  8. Phosphoproteomic analysis identifies FAK2 as a potential therapeutic target for tamoxifen resistance in breast cancer.

  9. Pyk2-focal adhesion targeting domain interacts with and binds to leupaxin (show LPXN Proteins).

  10. Src (show SRC Proteins) has a role in priming Pyk2 (but not FAK (show PTK2 Proteins)) phosphorylation and subsequent activation downstream of integrins

Cow (Bovine) PTK2B Protein tyrosine Kinase 2 beta (PTK2B) interaction partners

  1. Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]

PTK2B Protein Profile

Protein Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PTK2B

  • v-akt murine thymoma viral oncogene homolog 1 (Akt1)
  • thymoma viral proto-oncogene 1 (Akt1)
  • protein tyrosine kinase 2 beta (PTK2B)
  • protein tyrosine kinase 2 beta (Ptk2b)
  • PTK2 protein tyrosine kinase 2 beta (Ptk2b)
  • PTK2B protein tyrosine kinase 2 beta (PTK2B)
  • Akt protein
  • CADTK protein
  • CAKB protein
  • CAKbeta protein
  • E430023O05Rik protein
  • FADK2 protein
  • FAK2 protein
  • PKB protein
  • PKB/Akt protein
  • PKBalpha protein
  • PTK protein
  • Pyk2 protein
  • Rac protein
  • Raftk protein

Protein level used designations for PTK2B

AKT1 kinase , PKB alpha , RAC protein kinase alpha RAC-PK alpha , RAC-PK-alpha , RAC-alpha serine/threonine-protein kinase , murine thymoma viral (v-akt) oncogene homolog 1 , protein kinase B alpha , thymoma viral proto-oncogene 1 , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , CAK-beta , FADK 2 , PTK2B protein tyrosine kinase 2 beta , calcium-dependent tyrosine kinase , calcium-regulated non-receptor proline-rich tyrosine kinase , cell adhesion kinase beta , focal adhesion kinase 2 , proline-rich tyrosine kinase 2 , protein kinase B , protein-tyrosine kinase 2-beta , related adhesion focal tyrosine kinase , CADTK , CAK beta , PTK2 protein tyrosine kinase 2 beta , cellular adhesion kinase beta , protein tyrosine kinase 2 beta

GENE ID SPECIES
24185 Rattus norvegicus
11651 Mus musculus
2185 Homo sapiens
50646 Rattus norvegicus
19229 Mus musculus
486102 Canis lupus familiaris
541008 Bos taurus
421998 Gallus gallus
100157507 Sus scrofa
100342358 Oryctolagus cuniculus
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