Browse our anti-SPRY2 (SPRY2) Antibodies

Full name:
anti-Sprouty Homolog 2 (Drosophila) Antibodies (SPRY2)
On are 75 Sprouty Homolog 2 (Drosophila) (SPRY2) Antibodies from 13 different suppliers available. Additionally we are shipping SPRY2 Proteins (13) and many more products for this protein. A total of 92 SPRY2 products are currently listed.
hSPRY2, sprouty-2, sprouty2, wu:fk66h11, wu:fk93e11, Xsprouty2, xspry2, Xtsprouty2, zgc:110440
list all antibodies Gene Name GeneID UniProt
SPRY2 10253 O43597
SPRY2 24064 Q9QXV8
SPRY2 306141  

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Top referenced anti-SPRY2 Antibodies

  1. Human Monoclonal SPRY2 Primary Antibody for IF, IHC (p) - ABIN564439 : Barbáchano, Ordóñez-Morán, García, Sánchez, Pereira, Larriba, Martínez, Hernández, Landolfi, Bonilla, Pálmer, Rojas, Muñoz: SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity. in Oncogene 2010 (PubMed)
    Show all 3 references for 564439

  2. Cow (Bovine) Polyclonal SPRY2 Primary Antibody for IHC, WB - ABIN2784217 : Hsu, Lee, Hartstein, Harocopos: Clostridium perfringens Keratitis Leading to Blinding Panophthalmitis. in Cornea 2008 (PubMed)
    Show all 2 references for 2784217

  3. Human Polyclonal SPRY2 Primary Antibody for ELISA, WB - ABIN1043910 : August: Cerebrovascular and carotid artery disease. in Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2001 (PubMed)
    Show all 2 references for 1043910

  4. Cow (Bovine) Polyclonal SPRY2 Primary Antibody for WB - ABIN2784218 : Lee, Ho, Roy, Kosinski, Patil, Tward, Fridlyand, Chen: Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. in Hepatology (Baltimore, Md.) 2008 (PubMed)
    Show all 2 references for 2784218

  5. Human Polyclonal SPRY2 Primary Antibody for ELISA, ICC - ABIN4355751 : Zhang, Chaturvedi, Jaggar, Magnuson, Lee, Patel: Regulation of vascular smooth muscle cell proliferation and migration by human sprouty 2. in Arteriosclerosis, thrombosis, and vascular biology 2005 (PubMed)

More Antibodies against SPRY2 Interaction Partners

Xenopus laevis Sprouty Homolog 2 (Drosophila) (SPRY2) interaction partners

  1. Data show that the intracellular domain of PAPC interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.

  2. Here we show that Xenopus laevis Sprouty2 (XSpry2) controls the duration of ERK (show MAPK1 Antibodies) activity and thereby contributes to the establishment of dorsoventral patterning during mesoderm formation.

Human Sprouty Homolog 2 (Drosophila) (SPRY2) interaction partners

  1. upregulated in human CRC (show CALR Antibodies). Suppression of SPRY2 repressed AKT2 (show AKT2 Antibodies) and EMT (show ITK Antibodies)-inducing transcription factors and significantly increased E-cadherin (show CDH1 Antibodies) expression. Concurrent downregulation of SPRY1 (show SPRY1 Antibodies) and SPRY2 also increased E-cadherin (show CDH1 Antibodies) and suppressed mesenchymal markers in colon cancer cells.

  2. In cells harbouring a K-Ras (show HRAS Antibodies) mutation the serine conversion weakens the reduction of migration velocity indicating that dependent on the status of K-Ras (show HRAS Antibodies) the serine influences Sprouty2 functions differently.

  3. Increased nuclear localization of p21(WAF1/CIP1 (show CDKN1A Antibodies)) in SPRY2 downregulated colon cancer cells may explain the inhibition of cell proliferation in colon cancer cells.

  4. Data suggest a common mechanism by which DNA methyltransferase1 (DNMT1 (show DNMT1 Antibodies)) and hypoxia inducible factors HIF1alpha (show HIF1A Antibodies)/HIF2alpha (show EPAS1 Antibodies) regulate Sprouty2 (Spry2) transcription.

  5. We showed that Spry2 is a novel unfolded protein response target and its upregulation is de (show EIF2AK3 Antibodies)pendent on PERK.

  6. has an inhibitory role in TGFbeta (show TGFB1 Antibodies) signaling pathway in lens epithelial cells

  7. these results establish SPRY2 as a critical negative regulator of BCR (show BCR Antibodies)-mediated MAPK-Erk (show MAPK1 Antibodies) signaling in chronic lymphocytic leukemia , thereby providing one of the molecular mechanisms to explain the clinical heterogeneity of chronic lymphocytic leukemia.

  8. spry2 can inhibit MM cell growth and survival with a concomitant reduction in phosphorylation of extracellular signal-regulated kinases 1 and 2 in vitro and in vivo.

  9. data suggest that Spry2 acts as a scaffold to bring more pVHL (show VHL Antibodies)/associated E3 ligase in proximity of HIF1alpha (show HIF1A Antibodies) and increase its ubiquitylation and degradation. This represents a novel action for Spry2 in modulating biological processes regulated by HIFalpha subunits.

  10. MiR (show MLXIP Antibodies)-122 could act as a tumor promoter and potentially target Sprouty2. MiR (show MLXIP Antibodies)-122 promotes renal cell carcinoma (show MOK Antibodies) cell proliferation, migration, and invasion.

Mouse (Murine) Sprouty Homolog 2 (Drosophila) (SPRY2) interaction partners

  1. Spry2 is a novel unfolded protein response target and its upregulation is dependent on PERK (show EIF2AK3 Antibodies). Knockdown of Spry2 resulted in reduced expression of Serca2 (show ATP2A2 Antibodies), reduced endoplasmic reticulum calcium levels, and induction of the UPR. Spry2 deletion in the adult mouse beta-cell caused hyperglycemia and hypoinsulinemia.

  2. these results establish SPRY2 as a critical negative regulator of BCR (show BCR Antibodies)-mediated MAPK-Erk (show MAPK1 Antibodies) signaling in chronic lymphocytic leukemia , thereby providing one of the molecular mechanisms to explain the clinical heterogeneity of chronic lymphocytic leukemia.

  3. In the present study, it is demonstrated that Spry2 and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK (show EPHB2 Antibodies) signaling.

  4. Study revealed that suppression of Spry2 expression induced proliferation and differentiation of osteoblastic cells upon bFGF (show FGF2 Antibodies) and EGF (show EGF Antibodies) stimulation, whereas it diminished proliferation of gingival epithelial cells.

  5. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  6. in embryos with lower Spry2;Spry4 (show SPRY4 Antibodies) gene dosages, we observed a non-fusion of original R2 and M1 Shh (show SHH Antibodies) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud

  7. The data showed enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice

  8. Sprouty2 acts as an inhibitor of CrkL-Rap1 signaling.

  9. we reveal that SPRY2 expression is regulated by FOXO3a (show FOXO3 Antibodies) and beta-catenin (show CTNNB1 Antibodies) nuclear activity in colon cancer

  10. Spry1 (show SPRY1 Antibodies) and Spry2 coordination is required for normal development of the external genitalia in mice

SPRY2 Antigen Profile

Antigen Summary

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

Alternative names and synonyms associated with SPRY2

  • sprouty homolog 2 (spry2) antibody
  • sprouty homolog 2 (Drosophila) (SPRY2) antibody
  • sprouty homolog 2 (Drosophila) (Spry2) antibody
  • hSPRY2 antibody
  • sprouty-2 antibody
  • sprouty2 antibody
  • wu:fk66h11 antibody
  • wu:fk93e11 antibody
  • Xsprouty2 antibody
  • xspry2 antibody
  • Xtsprouty2 antibody
  • zgc:110440 antibody

Protein level used designations for SPRY2

protein sprouty homolog 2 , sprouty 2 , spry-2

335098 Danio rerio
449471 Xenopus (Silurana) tropicalis
100173576 Pongo abelii
398313 Xenopus laevis
10253 Homo sapiens
485504 Canis lupus familiaris
539090 Bos taurus
24064 Mus musculus
306141 Rattus norvegicus
395584 Gallus gallus
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