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anti-Human SPRY2 Antibodies:
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Human Monoclonal SPRY2 Primary Antibody for IF, IHC (p) - ABIN564439
Barbáchano, Ordóñez-Morán, García, Sánchez, Pereira, Larriba, Martínez, Hernández, Landolfi, Bonilla, Pálmer, Rojas, Muñoz: SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity. in Oncogene 2010
Show all 3 references for ABIN564439
Cow (Bovine) Polyclonal SPRY2 Primary Antibody for WB - ABIN2784218
Hsu, Lee, Hartstein, Harocopos: Clostridium perfringens Keratitis Leading to Blinding Panophthalmitis. in Cornea 2008
Show all 2 references for ABIN2784218
Human Polyclonal SPRY2 Primary Antibody for ELISA, WB - ABIN1043910
August: Cerebrovascular and carotid artery disease. in Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2001
Show all 2 references for ABIN1043910
Cow (Bovine) Polyclonal SPRY2 Primary Antibody for IHC, WB - ABIN2784217
Lee, Ho, Roy, Kosinski, Patil, Tward, Fridlyand, Chen: Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. in Hepatology (Baltimore, Md.) 2008
Show all 2 references for ABIN2784217
Human Polyclonal SPRY2 Primary Antibody for ELISA, ICC - ABIN4355751
Zhang, Chaturvedi, Jaggar, Magnuson, Lee, Patel: Regulation of vascular smooth muscle cell proliferation and migration by human sprouty 2. in Arteriosclerosis, thrombosis, and vascular biology 2005
Data show that the intracellular domain of PAPC interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.
Here we show that Xenopus laevis Sprouty2 (XSpry2) controls the duration of ERK (show MAPK1 Antibodies) activity and thereby contributes to the establishment of dorsoventral patterning during mesoderm formation.
these results establish SPRY2 as a critical negative regulator of BCR (show BCR Antibodies)-mediated MAPK-Erk (show MAPK1 Antibodies) signaling in chronic lymphocytic leukemia , thereby providing one of the molecular mechanisms to explain the clinical heterogeneity of chronic lymphocytic leukemia.
spry2 can inhibit MM cell growth and survival with a concomitant reduction in phosphorylation of extracellular signal-regulated kinases 1 and 2 in vitro and in vivo.
data suggest that Spry2 acts as a scaffold to bring more pVHL (show VHL Antibodies)/associated E3 ligase in proximity of HIF1alpha (show HIF1A Antibodies) and increase its ubiquitylation and degradation. This represents a novel action for Spry2 in modulating biological processes regulated by HIFalpha subunits.
MiR (show MLXIP Antibodies)-122 could act as a tumor promoter and potentially target Sprouty2. MiR (show MLXIP Antibodies)-122 promotes renal cell carcinoma (show MOK Antibodies) cell proliferation, migration, and invasion.
miR27b promotes the migration and invasion of gastric cancer cells via inhibition of SPRY2mediated ERK (show EPHB2 Antibodies) signaling.
Arg119Trp variant in the SPRY2 gene was identified as the probable IgA nephropathy-causing mutation. This variant is responsible for inhibition of the MAPK (show MAPK1 Antibodies)/ERK1/2 (show MAPK1/3 Antibodies) pathway.
SPRY2, counter to its roles in other cancer settings, promotes glioma cell and tumor growth and cellular resistance to targeted inhibitors of oncogenic RTKs
Data show that proto-oncogene (show RAB1A Antibodies) protein B (show LEPREL2 Antibodies)-raf (BRAF (show BRAF Antibodies)) inhibition induces c-Jun N-terminal kinase (c-JUN) expression and c-JUN (show JUN Antibodies) abundance and activation by down-regulating SPRY2/4 protein expression.
Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
The purpose of this study was to determine whether SPRY2 might have antiinflammatory effects on rheumatoid arthritis fibroblast-like synoviocytes.
In the present study, it is demonstrated that Spry2 and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK (show EPHB2 Antibodies) signaling.
Study revealed that suppression of Spry2 expression induced proliferation and differentiation of osteoblastic cells upon bFGF (show FGF2 Antibodies) and EGF (show EGF Antibodies) stimulation, whereas it diminished proliferation of gingival epithelial cells.
in embryos with lower Spry2;Spry4 (show SPRY4 Antibodies) gene dosages, we observed a non-fusion of original R2 and M1 Shh (show SHH Antibodies) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud
The data showed enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice
Sprouty2 acts as an inhibitor of CrkL-Rap1 signaling.
we reveal that SPRY2 expression is regulated by FOXO3a (show FOXO3 Antibodies) and beta-catenin (show CTNNB1 Antibodies) nuclear activity in colon cancer
Spry1 (show SPRY1 Antibodies) and Spry2 coordination is required for normal development of the external genitalia in mice
We propose that Sprouty genes(Spry2 and Spry4 (show SPRY4 Antibodies)) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution.
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
protein sprouty homolog 2
, sprouty 2