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ECM (show MMRN1 Proteins) over planar cell polarity mutant cells had reduced levels of laminin, Dally and Dlp (show DMD Proteins), and whereas Dpp-receiving ASP (show ASIP Proteins) cytonemes navigated in the Dally layer and required Dally (but not Dlp (show DMD Proteins)), FGF-receiving ASP (show ASIP Proteins) cytonemes navigated in the Dlp (show DMD Proteins) layer, requiring Dlp (show DMD Proteins) (but not Dally).
The authors show that Pent (show PNMT Proteins) internalises the Dpp co-receptors, the glypicans Dally and Dally-like protein (Dlp (show DMD Proteins)), and propose that this internalisation is important in the establishment of a long range Dpp gradient.
The expression of optix is activated by Dpp and repressed by the Spalt proteins, becoming restricted to the most anterior region of the wing blade.
En forms a complex with Nejire (show CREBBP Proteins) (Nej), the Drosophila ortholog of histone acetyltransferase CBP/p300 (show CREBBP Proteins), and directs Nej to this cis (show CISH Proteins)-regulatory region where Nej functions as the co-activator for dpp expression.
Basement membrane elimination, in contrast, attenuated signaling by bone morphogenetic protein/transforming growth factor beta ligand Dpp, which was not efficiently retained within the tissue and escaped to the body cavity.
This report provides a genetic analysis of primary nociceptive neuron mechanisms that promote sensitization in response to injury. Drosophila melanogaster larvae whose primary nociceptive neurons were reduced in levels of specific components of the BMP signaling pathway, were injured and then tested for nocifensive responses to a normally subnoxious stimulus.
Dad and Dpp activity is dynamically regulated in the adult Drosophila middle midgut.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (show EGFR Proteins)) pathway in the lateral epidermis for sustained dpp expression in the LE. Specifically, we demonstrate that Egfr (show EGFR Proteins) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK (show MAPK8 Proteins) signaling
In this work, we have explored the disc autonomous function of TGFbeta that promotes wing imaginal disc growth. We have studied the genetic interactions between TGFbeta signaling and other pathways regulating wing disc growth, such as the Insulin (show INS Proteins) and Hippo/Salvador/Warts pathways, as well as cell cycle regulators.
we discovered that the JNK (show MAPK8 Proteins) signaling pathway operated between Rab5 (show RAB5A Proteins) and Dpp, because simultaneously inhibiting the JNK (show MAPK8 Proteins) pathway and Rab5 (show RAB5A Proteins) in cyst cells prevented both dpp transcription and germline tumor growth
TGF beta (show TGFB1 Proteins) is involved in the pathogenesis of tympanosclerosis.
There was significantly higher expression of TGF-beta1 (show TGFB1 Proteins) and MMP-9 (show MMP9 Proteins) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.
Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo\; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development\; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes.
, Decapentaplegic/Bone morphogenetic protein
, bone morphogenetic protein
, bone morphogenic protein
, DPP receptor
, activin receptor
, activin receptor type II
, dorsal holes C
, transforming growth factor beta-1
, transforming growth factor-beta