TGF-beta Protein (TGFb)
TGFb
Origin: Human
Host: Hi-5 Cells
Recombinant
< 98 % by SDS-PAGE gel and HPLC analyses.
Active
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- Target See all TGF-beta (TGFb) Proteins
- TGF-beta (TGFb)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Origin
- Human
- Source
- Hi-5 Cells
- Sequence
- ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS
- Characteristics
- The ED50 was determined by its ability to inhibit the mouse IL - 4 - dependent proliferation of mouse HT - 2 cells. The ED50 was found to be < 0.2 ng/mL, corresponding to a specific activity of > 5 x 106 units/mg.
- Purity
- < 98 % by SDS-PAGE gel and HPLC analyses.
- Endotoxin Level
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Handling Advice
- As with any protein, exposing TGF Beta recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Storage
- -20 °C
- Storage Comment
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted TGF Beta is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
- Expiry Date
- 24 months
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- Target
- TGF-beta (TGFb)
- Alternative Name
- TGF beta (TGFb Products)
- Synonyms
- CED Protein, DPD1 Protein, LAP Protein, TGFB Protein, TGFbeta Protein, TGF-beta Protein, TGF-BETA-1 Protein, TGF-beta1 Protein, TGFbeta1 Protein, Tgfb Protein, Tgfb-1 Protein, transforming growth factor beta 1 Protein, transforming growth factor beta-1 Protein, transforming growth factor, beta 1 Protein, TGFB1 Protein, Tgfb1 Protein
- Background
- The three mammalian isoforms of TGF-beta, TGF-beta1, beta2, beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-beta2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
- Gene ID
- 7042
- NCBI Accession
- NP_001129071
- OMIM
- 208022653
- UniProt
- P61812
- Pathways
- EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
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