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study demonstrates that G. duodenalis-mediated disruption of villin is, at least, in part dependent on activation of myosin light chain kinase (show MYLK Proteins)
Thus, villin plays an important role in establishing the balance between actin polymerization and actin severing to facilitate the initial steps of Salmonella entry.
Collective expression pattern of tensin/profilin-1 (show PFN1 Proteins)/villin-1/talin could be a biomarker to estimate the prognosis of esophageal squamous cell carcinoma patients.
harmonin (show USH1C Proteins) and villin autoantibodies are sensitive and specific markers of IPEX (show FOXP3 Proteins), differentiate IPEX (show FOXP3 Proteins), including atypical cases, from other early childhood disorders associated with enteropathy
villin immunohistochemistry is a reliable and superior adjunct in the diagnosis of microvillus inclusion disease
Discriminated small-cell lung carcinoma from large-cell neuroendocrine lung carcinoma with immunohistochemical markers BAI3 (show BAI3 Proteins), CDX2 (show CDX2 Proteins) and VIL1.
We demonstrated that the VIL1 gene is a potential candidate molecular marker for high serum AFP (show AFP Proteins)-associated HCC (show FAM126A Proteins) and a predictive candidate for the postoperative recurrence and poorer prognosis of HCC (show FAM126A Proteins).
study confirmed finding of VIL1 as a diagnostic marker of cervical adenocarcinoma
identified villin, an actin-binding protein (show KPTN Proteins), as the 95 kDa antigen in four of five sera from patients with IPEX (show FOXP3 Proteins) syndrome
identified VIL1 as a novel biomarker of cervical adenocarcinoma
Competition between tryptophan fluorescence and electron transfer during unfolding of the villin headpiece.
villin severs F-actin to ensure microvillus depolarization and enterocyte remodeling upon intestinal injury
Villin-Cre(+);Klf4 (show KLF4 Proteins)(fl/fl (show FLT3LG Proteins)) have greater susceptibility to chemical-induced gastric carcinogenesis and increased rates of gastric tumor progression than control mice.
The data establish that meprins interact with and cleave villin and actin, and these cytoskeletal proteins are substrates for meprins.
a lack of villin does not significantly alter basal and secretagogue-stimulated electrolyte movements across the epithelium of the mouse jejunum in vivo
These results indicate that an important patterning event involving villin expression occurs in the gut (show GUSB Proteins) epithelium at 16 days, which may define the epithelial boundary between stomach and intestine.
different regulatory sequences of the villin gene regulate expression in the intestinal epithelium
Data show that villin, characteristic markers of brush borders, become abnormally distributed along these atypical basolateral membranes in gal3 (show LGALS3 Proteins)(-/-) mice.
Villin is an actin regulatory protein that organizes, integrates and regulates multiple epithelial cell functions.
VLN1 does not protect individual actin filaments from severing by VLN3.
This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed\; they result from utilization of alternate poly-adenylation signals present in the terminal exon.