Browse our ATF6 Proteins (ATF6)

Full name:
Activating Transcription Factor 6 Proteins (ATF6)
On are 11 Activating Transcription Factor 6 (ATF6) Proteins from 4 different suppliers available. Additionally we are shipping ATF6 Antibodies (173) and ATF6 Kits (19) and many more products for this protein. A total of 214 ATF6 products are currently listed.
9130025P16Rik, 9630036G24, AA789574, ATF-6-like, Atf6, ATF6A, Atf6alpha, ESTM49, GB16435
list all proteins Gene Name GeneID UniProt
ATF6 22926 P18850
ATF6 226641  
Rat ATF6 ATF6 304962  

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ATF6 Proteins (ATF6) by Origin

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More Proteins for ATF6 Interaction Partners

Human Activating Transcription Factor 6 (ATF6) interaction partners

  1. Low ATF6 expression is associated with cancer.

  2. Activating transcription factor 6 (ATF6alpha) pathway and ER-associated protein degradation (ERAD) are elevated in salivary glands of Sjogren's syndrome patients (SS).

  3. A transcription factor complex consisting of ATF6 (an endoplasmic reticulum-resident factor) and C/EBP-beta (show CEBPB Proteins) is required for the IFN-gamma-induced (show SAMHD1 Proteins) expression of DAPK1 (show DAPK1 Proteins) IFN-gamma-induced (show SAMHD1 Proteins) proteolytic processing of ATF6 and phosphorylation of C/EBP-beta (show CEBPB Proteins) are obligatory for the formation of this transcriptional complex

  4. Authors observed the cleavage of ATF6, the phosphorylation of MRLC, and the expression of death-associated protein kinase (DAPK1 (show DAPK1 Proteins)) by western blotting; the transcription of DAPK1 (show DAPK1 Proteins) by RT-PCR; and the subcellular localization of ATF6 and mAtg9 (show ATG9A Proteins) by immunofluorescence.

  5. Genetic Variations in ATF6 (rs2070150) is not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection.

  6. We found that HCS (show HLCS Proteins) identified compounds which inhibited ATF6 nuclear translocation with high specificity, as confirmed by the luciferase reporter assay and western blot analysis

  7. results identify a role for DREAM silencing in the activation of ATF6 signaling, which promotes early neuroprotection in HD.

  8. Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.

  9. Defective podocyte insulin (show INS Proteins) signaling through p85-XBP1 (show XBP1 Proteins) promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.

  10. protein expression were significantly higher in the placentas of women with early and late SPE than in the control women, whereas there were no differences in ATF6 and Ire1 (show ERN1 Proteins) mRNA and protein.

Mouse (Murine) Activating Transcription Factor 6 (ATF6) interaction partners

  1. Forced activation of the ATF6 UPR branch reduced infarct volume and improved functional outcome at 24 h after stroke

  2. However, depletion of XBP1 (show XBP1 Proteins) and ATF6, alone or in combination, prevented autophagy induction and significantly enhanced Japanese encephalitis virus-induced cell death.

  3. Deletion of Atf6alpha suppressed inflammation, and ameliorated demyelination after experimental autoimmune encephalomyelitis.

  4. we show that overexpression of the dominant-negative form of ATF6 (dnATF6) increases susceptibility to develop hepatic steatosis in diet-induced insulin (show INS Proteins)-resistant mice and fasted mice. Furthermore, hepatic overexpression of the active form of ATF6 promotes hepatic fatty acid oxidation and protects against hepatic steatosis in diet-induced insulin (show INS Proteins)-resistant mice.

  5. The present study extends our understanding and provides new insights into the physiological significance of ATF6, a key signal transducer of ER stress, in ovarian granulosa cells.

  6. ATF6 serves as an important role between ER stress and oxidative stress, by decreasing myocardial ischemia/reperfusion damage.

  7. ATF6alpha mRNA and protein levels were higher in the uterus near the implantation site following embryo implantation.

  8. ATF6a favorably controls chondrogenesis and bone formation (1) by acting as a co-factor of Runx2 and enhancing Runx2-incited hypertrophic chondrocyte differentiation, and (2) by affecting IHH and PTHrP signaling.

  9. Data show that EIF2AK3/PERK (show EIF2AK3 Proteins)-mediated downregulation of miR (show MLXIP Proteins)-424(322)-503 cluster regulates optimal activation of IRE1 (show ERN1 Proteins) protein and activating transcription factor 6 (ATF6) during conditions of endoplasmic reticulum stress.

  10. Our results suggest that ATF6alpha plays an important role in neuronal survival after KA-induced excitotoxicity through the regulation of Ca(2 (show CA2 Proteins)+) response and neuronal activity

Cow (Bovine) Activating Transcription Factor 6 (ATF6) interaction partners

  1. Exposure of endothelial cells to VEGF (show VEGFA Proteins), high glucose, or hydrogen peroxide up-regulated the XBP1 (show XBP1 Proteins)/IRE1 alpha (show ERN1 Proteins) and ATF6 arms of the unfolded protein response compared with untreated cells.

ATF6 Protein Profile

Protein Summary

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

Alternative names and synonyms associated with ATF6

  • activating transcription factor 6 (ATF6)
  • activating transcription factor 6 (Atf6)
  • activating transcription factor 6 (atf6)
  • 9130025P16Rik protein
  • 9630036G24 protein
  • AA789574 protein
  • ATF-6-like protein
  • Atf6 protein
  • ATF6A protein
  • Atf6alpha protein
  • ESTM49 protein
  • GB16435 protein

Protein level used designations for ATF6

activating transcription factor 6 , cyclic AMP-dependent transcription factor ATF-6 alpha-like , cAMP-dependent transcription factor ATF-6 alpha , cyclic AMP-dependent transcription factor ATF-6 alpha

100051169 Equus caballus
412432 Apis mellifera
457461 Pan troglodytes
496056 Xenopus laevis
720056 Macaca mulatta
100122162 Nasonia vitripennis
100451142 Pongo abelii
22926 Homo sapiens
226641 Mus musculus
304962 Rattus norvegicus
100158076 Sus scrofa
530610 Bos taurus
100358536 Oryctolagus cuniculus
100730337 Cavia porcellus
488660 Canis lupus familiaris
424365 Gallus gallus
541606 Ovis aries
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