ATF6 Products
(Activating Transcription Factor 6 (ATF6))
Categories
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011].
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Featured ATF6 Categories
ATF6 Antibodies
High quality antibodies with extensive validation data.
ATF6 ELISA Kits
Reliable ELISA kits for a wide range of species.
ATF6 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ATF6 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
- (9)
Cat. No.
ABIN1512605
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7440587
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (1)
- (4)
Cat. No.
ABIN652625
Quantity
400 μL
Datasheet
Datasheet
Recommended ATF6 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964572
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964573
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962051
Quantity
96 tests
Datasheet
Datasheet
Recommended ATF6 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121670
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345942
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345944
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ATF6 products
: "Ebola Virus Activates IRE1α-Dependent XBP1u Splicing." in: Viruses, Vol. 15, Issue 1, (2023) (PubMed).: "Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol." in: Antioxidants (Basel, Switzerland), Vol. 9, Issue 8, (2020) (PubMed).
: "Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis." in: Scientific reports, Vol. 7, Issue 1, pp. 5941, (2019) (PubMed).
: "EMC3 coordinates surfactant protein and lipid homeostasis required for respiration." in: The Journal of clinical investigation, Vol. 127, Issue 12, pp. 4314-4325, (2019) (PubMed).
: "Expressions of ATF6, XBP1, and GRP78 in normal tissue, atypical adenomatous hyperplasia, and adenocarcinoma of the lung." in: Human pathology, Vol. 83, pp. 22-28, (2019) (PubMed).
: "IL-6 mediates ER expansion during hyperpolarization of alternatively activated macrophages." in: Immunology and cell biology, Vol. 97, Issue 2, pp. 203-217, (2019) (PubMed).
: "Imatinib‑induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress." in: Oncology reports, Vol. 41, Issue 3, pp. 1616-1626, (2019) (PubMed).
: "The effect of Tmem135 overexpression on the mouse heart." in: PLoS ONE, Vol. 13, Issue 8, pp. e0201986, (2019) (PubMed).
: "Tauroursodeoxycholic acid attenuates cyclosporine-induced renal fibrogenesis in the mouse model." in: Biochimica et biophysica acta. General subjects, Vol. 1863, Issue 7, pp. 1210-1216, (2019) (PubMed).
: "C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes." in: American journal of physiology. Endocrinology and metabolism, Vol. 316, Issue 6, pp. E1081-E1092, (2019) (PubMed).
Synonyms and alternative names related to ATF6
activating transcription factor 6 (ATF6), uncharacterized LOC412432 (LOC412432), activating transcription factor 6 S homeolog (atf6.S), cyclic AMP-dependent transcription factor ATF-6 alpha (LOC100122162), activating transcription factor 6 (Atf6), 9130025P16Rik, 9630036G24, AA789574, ATF-6-like, ATF6, Atf6, ATF6A, Atf6alpha, ESTM49, GB16435Protein level used designations for ATF6
- activating transcription factor 6
- cyclic AMP-dependent transcription factor ATF-6 alpha-like
- cAMP-dependent transcription factor ATF-6 alpha
- cyclic AMP-dependent transcription factor ATF-6 alpha
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