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anti-Human NRF2 Antibodies:
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Human Polyclonal NRF2 Primary Antibody for IF (p), IHC (p) - ABIN737271
Lee, Hsu, Chang, Kuo, Hsu, Pan: Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. in Free radical biology & medicine 2012
Show all 16 Pubmed References
Human Polyclonal NRF2 Primary Antibody for IHC (fro), IF (p) - ABIN676673
Lee, Hsu, Hsu, Pan: Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid. in Free radical biology & medicine 2013
Show all 16 Pubmed References
Human Polyclonal NRF2 Primary Antibody for IHC, IHC (p) - ABIN4340688
Suchocki, Misiewicz-Krzemińska, Skupińska, Niedźwiecka, Lubelska, Fijałek, Kasprzycka-Guttman: Selenitetriglicerydes affect CYP1A1 and QR activity by involvement of reactive oxygen species and Nrf2 transcription factor. in Pharmacological reports : PR 2010
Show all 3 Pubmed References
Human Polyclonal NRF2 Primary Antibody for ChIP, ICC - ABIN442777
Sullivan, Martinez-Garcia, Nguyen, Mullen, Dufour, Sudarshan, Licht, Deberardinis, Chandel: The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. in Molecular cell 2013
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Human Polyclonal NRF2 Primary Antibody for ICC, IHC (p) - ABIN3044196
Wang, Du, Duan, Guo, Sun, Liu: Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation. in World journal of gastroenterology : WJG 2013
Show all 2 Pubmed References
Human Polyclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1584873
Bagul, Middela, Matapally, Padiya, Bastia, Madhusudana, Reddy, Chakravarty, Banerjee: Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. in Pharmacological research : the official journal of the Italian Pharmacological Society 2012
Show all 2 Pubmed References
Human Polyclonal NRF2 Primary Antibody for IHC (p), WB - ABIN3043888
Li, Xie, Chen, Wang, Yu: Hydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1. in The Journal of surgical research 2015
Show all 2 Pubmed References
Human Monoclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1724931
Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. in Physiological genomics 2012
Human Monoclonal NRF2 Primary Antibody for IF, ELISA - ABIN518315
Lindl, Jordan-Sciutto: Examining the endogenous antioxidant response through immunofluorescent analysis of Nrf2 in tissue. in Methods in molecular biology (Clifton, N.J.) 2008
These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.
we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (show AKT1 Antibodies) and JNK (show MAPK8 Antibodies)/Nrf2/NQO1 (show NQO1 Antibodies) pathway.
Bach1 (show BACH1 Antibodies) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Antibodies) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf (show NRF1 Antibodies) genes varies temporally throughout development and nrf (show NRF1 Antibodies) genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b (show GABPb Antibodies).
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Antibodies) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Antibodies) gene expression in aortic endothelial cells by advanced glycation end products
Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
Study provides evidence that KEAP1 (show KEAP1 Antibodies)/NRF2 (show GABPA Antibodies) mutations increase radioresistance and predict local tumor recurrence in radiotherapy treated LSCC patients.
NFE2L2 genetic variant is associated with heart rate variability in obese patients.
Expression of either dominant-negative or constitutively active mutants of Nrf2 (show GABPA Antibodies), ATF4 (show ATF4 Antibodies), or c-Jun (show JUN Antibodies) confirmed that distinct transcription units are regulated by these transcription factors.
Nrf2 (show GABPA Antibodies)-driven TERT (show TERT Antibodies) regulates pentose phosphate pathway in glioblastoma.
Nrf2 (show GABPA Antibodies) inhibition in Dendritic Cells (DC) in glioma-exposed microenvironment could enhance the maturation of DCs and the subsequent activation of T cells and their cytotoxicity on glioma cells.
Epigallocatechin-3-Gallate protects against Ang II (show AGT Antibodies)-induced HUVEC apoptosis by decreasing oxidative stress and ameliorating mitochondrial injury via activation of Nrf2 (show GABPA Antibodies)/casp3 (show CASP3 Antibodies) signaling pathway.
PRMT1 (show PRMT1 Antibodies) methylates Nrf2 (show GABPA Antibodies) protein at a single residue of arginine 437, both in vitro and in vivo. This leads to a moderate increase of its DNA-binding activity and transactivation, which subsequently protects cells against the tBHP-induced glutathione depletion and cell death. This novel modification of Nrf2 (show GABPA Antibodies) operates as a fine-tuning mechanism for the transcriptional activity of Nrf2 (show GABPA Antibodies) under oxidative stress.
Study showed that Sequestosome 1 (show SQSTM1 Antibodies)-mediated sequestration of Keap1 (show KEAP1 Antibodies) is associated with chronic activation of the Nrf2 (show GABPA Antibodies) stress response pathway in the autophagic vacuolar myopathie muscle; demonstrated that Nrf2 (show GABPA Antibodies) signaling is upregulated in autophagic muscle disorders and raise the possibility that autophagy disruption in skeletal muscle leads to dysregulation of cellular redox homeostasis.
ARF (show CDKN2A Antibodies) inhibits tumor growth by suppressing the ability of NRF2 (show GABPA Antibodies) to transcriptionally activate its target genes, including SLC7A11 (show SLC7A11 Antibodies), a component of the cystine/glutamate (show GRIN1 Antibodies) antiporter that regulates reactive oxygen species (ROS (show ROS1 Antibodies))-induced ferroptosis.
Keap1 (Kelch-like ECH-associated protein 1 (show KEAP1 Antibodies)) is an adaptor subunit of Cullin 3 (show CUL3 Antibodies)-based E3 ubiquitin ligase (show MUL1 Antibodies). Keap1 (show KEAP1 Antibodies) regulates the activity of Nrf2 (show GABPA Antibodies) and acts as a sensor for oxidative and electrophilic stresses.
Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 recruitment to the Srebp-1c (show SREBF1 Antibodies) promoter in livers of BPA (show DST Antibodies)-exposed mice was observed.
Novel transcriptional role of miR140-5p in the expression of Nrf2; miR (show MLXIP Antibodies)-140-5p protected against Cisplatin induced oxidative stress by activating Nrf2-dependent antioxidant pathway, providing a potentially therapeutic target in acute kidney injury.
Saffron (Crocus sativus) protects against myocardial ischemia-reperfusion injury in Wild Type and ApoE (show APOE Antibodies)((-/-)) mice via Nrf2 pathway.
High NRF2 expression is associated with Hepatocarcinogenesis.
Theraputic effects of Pirfenidone for induced pulmonary fibrosis were involved in Nrf2/Bach1 (show BACH1 Antibodies) equilibrium which regulated the capacity of oxidative stress.
Nrf2-driven TERT (show TERT Antibodies) regulates pentose phosphate pathway in glioblastoma.
Hyperactivation of Nrf2 in the initial phase of injury prevents the progression of reactive oxygen species-mediated tubular damage by inducing antioxidant enzymes and NADPH synthesis.
The results indicate that adipose-derived mesenchymal stem cells (ADSCs) can increase the survival of fat transplants through the modulation of inflammatory and oxidative responses via Nrf2 and TLR4 (show TLR4 Antibodies), suggesting potential strategies to improve the use of ADSCs for cell therapy.
serine 351 phosphorylation of p62 (show GTF2H1 Antibodies) did not enhance its binding to Keap1 (show KEAP1 Antibodies) or stabilise the nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor in this neuronal context. Nrf2 protein levels were markedly decreased despite transcriptional activation of the Nrf2 gene
These findings demonstrated that apigenin could prevent the D-GalN (show GAL Antibodies)/LPS (show TLR4 Antibodies)-induced liver injury in mice, and its mechanisms might be associated with the increments of Nrf-2-mediated antioxidative enzymes and modulation of PPARgamma (show PPARG Antibodies)/NF-kappaB (show NFKB1 Antibodies)-mediated inflammation.
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2