NRF2 antibody (AA 356-589)

Catalog No. ABIN1724931

Cited in 1 publication. The Mouse Monoclonal anti-NRF2 antibody (Clone 1A6G6) (ABIN1724931) specifically detects NRF2 in IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for NRF2 antibody (AA 356-589) (ABIN1724931)

Target: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NRF2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: 1A6G6

Product Details anti-NRF2 Antibody

Binding Specificity: AA 356-589

Purpose: NFE2L2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human NFE2L2 (AA: 356-589) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-NRF2 antibody (ABIN1724931)

Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: "NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease." in: Physiological genomics, Vol. 44, Issue 15, pp. 754-63, (2012) (PubMed).

Target Details for NRF2

Target: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Alternative Name: NFE2L2

Background: This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters, many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 67.8 kDa

UniProt: Q16236

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling