Browse our BTK Proteins (BTK)

Full name:
Bruton Agammaglobulinemia tyrosine Kinase Proteins (BTK)
On www.antibodies-online.com are 24 Bruton Agammaglobulinemia tyrosine Kinase (BTK) Proteins from 10 different suppliers available. Additionally we are shipping BTK Antibodies (291) and BTK Kits (44) and many more products for this protein. A total of 375 BTK products are currently listed.
Synonyms:
AGMX1, AI528679, AT, ATK, BPK, BTK, IMD1, PSCTK1, xid, XLA
list all proteins Gene Name GeneID UniProt
BTK 695 Q06187
BTK 12229 P35991
BTK 367901  

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BTK Proteins (BTK) by Origin

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Top referenced BTK Proteins

  1. Human BTK Protein expressed in Baculovirus infected Insect Cells - ABIN2003090 : Hashimoto, Tsukada, Matsushita, Miyawaki, Niida, Yachie, Kobayashi, Iwata, Hayakawa, Matsuoka, Tsuge, Yamadori, Kunikata, Arai, Yoshizaki, Taniguchi, Kishimoto: Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan. in Blood 1996 (PubMed)
    Show all 3 references for 2003090

  2. Human BTK Protein expressed in Baculovirus infected Insect Cells - ABIN2003091 : Vihinen, Nore, Mattsson, Bäckesjö, Nars, Koutaniemi, Watanabe, Lester, Jones, Ochs, Smith: Missense mutations affecting a conserved cysteine pair in the TH domain of Btk. in FEBS letters 1997 (PubMed)
    Show all 3 references for 2003091

More Proteins for BTK Interaction Partners

Human Bruton Agammaglobulinemia tyrosine Kinase (BTK) interaction partners

  1. the results show that the interaction between BTK and ANKRD54 is highly selective, since it was also identified in a screen using human SH3-domainome. A novel finding is that BTK not only binds to ANKRD54, but stands out as the preferred interactor, being highly dominant over all other human SH3-domains.

  2. this study elucidated mechanisms of BCL2 (show BCL2 Proteins) overexpression and association of this survival pathway with the BCR (show BCR Proteins)/BTK signaling pathway in MCL (show FH Proteins), and revealed the role of BTK in noncanonical NF-kappaB (show NFKB1 Proteins) activation, which also promotes cancer cell survival.

  3. BTK, via p65BTK expression, is a novel and powerful oncogene (show RAB1A Proteins) acting downstream of the RAS/MAPK (show MAPK1 Proteins) pathway and suggest that its targeting may be a promising therapeutic approach.

  4. We conclude that despite being involved in oncogenic signals in blood malignancies, BTK has antineoplastic properties in other contexts, such as the enhancement of p53 (show TP53 Proteins)'s tumor suppressor responses

  5. Inhibition of Btk by inhalation of aerosolized RN983 may be effective as a stand-alone asthma therapy.

  6. LMP2A signaling results in STAT3 (show STAT3 Proteins) phosphorylation in B cells through a PI3K (show PIK3CA Proteins)/BTK-dependent pathway.

  7. Case Report: Btk mutation responsible for X-Linked agammaglobulinemia manifesting as Pseudomonas aeruginosa liver abscess.

  8. this review describes contributions of BTK to immune tolerance, including studies testing BTK-inhibitors for treatment of autoimmune diseases

  9. The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin.

  10. report that BTK is expressed by murine and human MDSCs, and that ibrutinib is able to inhibit BTK phosphorylation in these cells

Mouse (Murine) Bruton Agammaglobulinemia tyrosine Kinase (BTK) interaction partners

  1. Rictor positively regulates B cell receptor signaling via up-regulating Btk and down-regulating SH2-containing inositol phosphatase (show INPP5D Proteins)

  2. The pre-B-cell receptor (pre-BCR (show BCR Proteins)) signaling molecules BLNK (show BLNK Proteins), BTK and BANK1 (show BANK1 Proteins) were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR (show BCR Proteins) signaling pathway.

  3. these data indicate that in mature B cells, Tec and Btk may compete for activation of the Akt signaling pathway, whereby the activating capacity of Btk is limited by the presence of Tec kinase.

  4. these data demonstrate that enhanced BTK signaling in B cells can establish a T cell-driven proinflammatory loop resulting in autoimmune pathology, making BTK inhibition an attractive therapeutic strategy

  5. Inhibition of Btk by inhalation of aerosolized RN983 may be effective as a stand-alone asthma therapy.

  6. Btk and NLRP3 (show NLRP3 Proteins) co-regulate platelet activation, aggregation, and in vitro thrombus formation.The NLRP3 (show NLRP3 Proteins) inflammasome is upregulated in activated platelets.

  7. Btk inhibition ameliorated hepatocellular injury in a well-established model of liver partial warm ischemia and in situ reperfusion.

  8. report that BTK is expressed by murine and human MDSCs, and that ibrutinib is able to inhibit BTK phosphorylation in these cells

  9. ITK (show ITK Proteins) and BTK regulate thermal homeostasis during septic response through mast cell function in mice.

  10. Btk inhibition treats TLR7 (show TLR7 Proteins)/IFN driven murine lupus

Cow (Bovine) Bruton Agammaglobulinemia tyrosine Kinase (BTK) interaction partners

  1. inositol hexakisphosphate (IP6 (show GPRIN2 Proteins)), a soluble signaling molecule found in both animal and plant cells, also activates Btk.

BTK Protein Profile

Protein Summary

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.

Alternative names and synonyms associated with BTK

  • Bruton agammaglobulinemia tyrosine kinase (BTK)
  • Bruton agammaglobulinemia tyrosine kinase (btk)
  • Bruton agammaglobulinemia tyrosine kinase (Btk)
  • AGMX1 protein
  • AI528679 protein
  • AT protein
  • ATK protein
  • BPK protein
  • BTK protein
  • IMD1 protein
  • PSCTK1 protein
  • xid protein
  • XLA protein

Protein level used designations for BTK

Bruton agammaglobulinemia tyrosine kinase , B-cell progenitor kinase , agammaglobulinaemia tyrosine kinase , dominant-negative kinase-deficient Brutons tyrosine kinase , tyrosine-protein kinase BTK , tyrosine-protein kinase BTK isoform (lacking exon 14) , ATK , BPK , Bruton's tyrosine kinase , Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) , X-linked immune deficiency , agammaglobulinemia tyrosine kinase , bruton tyrosine kinase , kinase EMB

GENE ID SPECIES
100057626 Equus caballus
465759 Pan troglodytes
568653 Danio rerio
703000 Macaca mulatta
100170477 Xenopus (Silurana) tropicalis
100354225 Oryctolagus cuniculus
100594539 Nomascus leucogenys
695 Homo sapiens
12229 Mus musculus
367901 Rattus norvegicus
492019 Canis lupus familiaris
100627308 Sus scrofa
533459 Bos taurus
374075 Gallus gallus
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