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Meta-analysis suggests that FGF20 rs1721100 C/G polymorphism is associated with sporadic sporadic Parkinson's diseases in Asians
The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson's disease under a recessive model.
The results showed no significant differences in the presence of rs1721100 or rs12720208 in the FGF20 gene between Parkinson's disease patients and controls.
The results have not shown any effect of rs12720208 in the FGF20 gene on the risk of Parkinson's disease in patients residing in Russia
This study revealed that the rs1721100(C/G) polymorphism is a risk factor for PD in Han Chinese population, while rs12720208(C/T) polymorphism is not significantly associated with Parkinson's disease.
The data suggested that Fgf9/20 and Bmp7 organize the n (show BMP7 ELISA Kits)ephron progenitor niche and highlight the essential role of FGF20 in human kidney development. FGF signaling likely regulates multiple important steps in the stem cell niche.
The common FGF20 rs12720208 SNP was not associated with the risk for Parkinson's disease (PD) in our population. In addition, we did not find nucleotide changes in miR (show MLXIP ELISA Kits)-433 (that binds to the 3' UTR (show UTS2R ELISA Kits) FGF20 mRNA) among our PD patients.
The associations described, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging.
Fibroblast growth factor 20 polymorphisms and haplotypes is associated with the risk of Parkinson disease
Data show that FGF20 and DKK1 (show DKK1 ELISA Kits) appear to be direct targets for beta-catenin (show CTNNB1 ELISA Kits)/TCF (show HNF4A ELISA Kits) transcriptional regulation via LEF/TCF (show HNF4A ELISA Kits)-binding sites, and are expressed early in Xenopus embryogenesis under the control of the Wnt (show WNT2 ELISA Kits) signaling pathway
Data show that Fibroblast Growth Factors (FGF) 9 and 20 regulate the number of cochlear progenitors.
fibroblast growth factor 20 (Fgf20) is expressed in hair placodes and is induced by and functions downstream from epithelial ectodysplasin (Eda (show EDA ELISA Kits))/Edar (show EDAR ELISA Kits) and Wnt (show WNT2 ELISA Kits)/beta-Catenin (show CTNNB1 ELISA Kits) signaling to initiate formation of the underlying dermal condensation
We hypothesized that Fgf20 plays a role in specification, amplification, or maintenance of Sox2 (show SOX2 ELISA Kits) expression in prosensory progenitors of the developing mammalian cochlea.
Fgf20 is a major downstream effector of ectodysplasin and affects ectodysplasin-regulated characteristics of tooth morphogenesis, including the number, size and shape of teeth.
The data suggested that, at a minimum, Fgf9/20 and Bmp7 (show BMP7 ELISA Kits) organize the nephron progenitor niche. FGF signaling likely regulates multiple important steps in the niche, including survival, proliferation, and competence.
Data indicate that the viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans.
expression of FGF20 in calvarial and limb development
Fgf20 is expressed at the right time and place to mediate sensory cell specification and is the likely activator/ligand of fibroblast growth factor (FGF) receptor 1 during cochlear development.
The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility.
fibroblast growth factor 20