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Browse our IRS2 (IRS2) ELISA Kits

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Insulin Receptor Substrate 2 ELISA Kits (IRS2)
On are 25 Insulin Receptor Substrate 2 (IRS2) ELISA Kits from 6 different suppliers available. Additionally we are shipping IRS2 Antibodies (68) and IRS2 Proteins (4) and many more products for this protein. A total of 101 IRS2 products are currently listed.
4PS, Irs-2, IRS2, si:dkeyp-24d6.1
list all ELISA KIts Gene Name GeneID UniProt
IRS2 8660 Q9Y4H2
IRS2 29376  
IRS2 384783 P81122

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More ELISA Kits for IRS2 Interaction Partners

Zebrafish Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. Data show that JNK3 (show MAPK10 ELISA Kits) silencing strongly decreases Insulin Receptor Substrate 2 (IRS2) protein expression.

Human Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. In the renal proximal tubule, insulin (show INS ELISA Kits) signaling via IRS1 (show IRS1 ELISA Kits) is inhibited, while insulin (show INS ELISA Kits) signaling via IRS2 is preserved. Insulin (show INS ELISA Kits) signaling via IRS2 continues to stimulate sodium reabsorption in the proximal tubule and causes sodium retention, edema, and hypertension.

  2. miRNA-146a may function as a useful clinical tool in the treatment and diagnosis of ESCC, and its overexpression suppressed cell growth through inhibition of IRS2.

  3. High IRS2 expression is associated with myeloproliferative neoplasms.

  4. FSH (show BRD2 ELISA Kits) decreases IRS-2 mRNA degradation indicating post-transcriptional stabilization.

  5. These data demonstrate for the first time that miR146a suppresses lung cancer progression by repressing IRS2 expression

  6. IRS (show IARS ELISA Kits)-specific gene signatures represent accurate surrogates of IGF activity and could predict response to anti-IGF therapy in breast cancer.

  7. Amplification of CUL4A (show CUL4A ELISA Kits), IRS2, and TFDP1 (show TFDP1 ELISA Kits) genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma.

  8. These results indicate that miR (show MLXIP ELISA Kits)-106a* affects renal cell carcinoma (RCC (show XRCC1 ELISA Kits)) progression by targeting IRS-2 with suppression of the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling pathway in RCC (show XRCC1 ELISA Kits) cells

  9. meta-analysis of genetic association studies: Data suggest that the D allele of the G1057D SNP in IRS2 has a significant effect on reducing risk of type 2 diabetes mellitus; obesity is a modifier of this association. [META-ANALYSIS, REVIEW]

  10. We conclude that AFB1 may upregulate IRS2 and stimulate lung cancer cell migration through Src (show SRC ELISA Kits)

Mouse (Murine) Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. Acute knockdown of Insr (show INSR ELISA Kits) or both Irs1 (show IRS1 ELISA Kits) and Irs2 in adipocytes increased Adipoq (show ADIPOQ ELISA Kits) mRNA expression but reduced adiponectin (show ADIPOQ ELISA Kits) secretion.

  2. Combination of DPP-4 (show DPP4 ELISA Kits) inhibitor and PPARgamma (show PPARG ELISA Kits) agonist exerts protective effects on pancreatic beta-cells in diabetic db/db (show LEPR ELISA Kits) mice through the augmentation of IRS-2 expression

  3. discovered that Irs2 deficiency causes insulin resistance through up-regulation of the phosphatase and tensin homolog (PTEN). Importantly, suppressing PTEN in Irs2(-/-) podocytes rescued insulin sensitivity

  4. A knockout mouse has confirmed the importance of IRS2 in the control of glucose homeostasis and especially in the survival and function of pancreatic beta-cells.

  5. The data suggest that Irs2 deletion in endothelial cells leads to a decreased islet blood flow, which may cause impaired glucose-induced insulin (show INS ELISA Kits) secretion.

  6. Results indicate that although IRS (show IARS ELISA Kits) isoforms (irs1 (show IRS1 ELISA Kits) and irs2) play divergent roles in the developmental regulation of cardiac size, these isoforms exhibit nonredundant roles in mediating the hypertrophic and metabolic response of the heart to exercise.

  7. Inhibition of Gsk-3beta by Irs-2-dependent PI3K signaling promotes glucose uptake and aerobic glycolysis.

  8. Data (including data from knockout mice) suggest that Irs2 is not required for islet beta-cell proliferation (as seen with high-fat diet) but may be needed for beta-cell regeneration (as seen after partial pancreatectomy).

  9. IRS2 plays a critical role in testicular development, potentially by mediating IGF1 (show IGF1 ELISA Kits) signaling during embryonic and early postnatal development.

  10. Mice with combined cardiomyocyte-specific deletion of Irs1 & Irs2 (show IRS1 ELISA Kits) had unrestrained autophagy in cardiomyocytes, leading to myocyte loss, heart failure, premature death, apoptosis & mitochondrial dysfunction.

Cow (Bovine) Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. The study identified the serine phosphorylation (p-Ser (show SIGLEC1 ELISA Kits)) sites induced by PKC-Beta (show PRKCB ELISA Kits) activation or AGT (show AGT ELISA Kits), which inhibits insulin (show INS ELISA Kits)-induced p-Tyr (show TYR ELISA Kits) sites on IRS2 and its signals in endothelial cells.

IRS2 Antigen Profile

Antigen Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

Alternative names and synonyms associated with IRS2

  • insulin receptor substrate 2 (IRS2) Elisa Kit
  • zgc:56306 (zgc:56306) Elisa Kit
  • insulin receptor substrate 2 (irs2) Elisa Kit
  • insulin receptor substrate 2 (Irs2) Elisa Kit
  • 4PS Elisa Kit
  • Irs-2 Elisa Kit
  • IRS2 Elisa Kit
  • si:dkeyp-24d6.1 Elisa Kit

Protein level used designations for IRS2

insulin receptor substrate 2 , tyrosine kinase substrate , 4PS

100146249 Equus caballus
393285 Danio rerio
452657 Pan troglodytes
572001 Danio rerio
8660 Homo sapiens
29376 Rattus norvegicus
384783 Mus musculus
100730395 Cavia porcellus
485548 Canis lupus familiaris
100300012 Bos taurus
428017 Gallus gallus
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