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Browse our IRS2 Proteins (IRS2)

Full name:
Insulin Receptor Substrate 2 Proteins (IRS2)
On are 4 Insulin Receptor Substrate 2 (IRS2) Proteins from 3 different suppliers available. Additionally we are shipping IRS2 Antibodies (72) and IRS2 Kits (26) and many more products for this protein. A total of 106 IRS2 products are currently listed.
4PS, Irs-2, IRS2, si:dkeyp-24d6.1
list all proteins Gene Name GeneID UniProt
IRS2 8660 Q9Y4H2
Rat IRS2 IRS2 29376  
IRS2 384783 P81122

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IRS2 Proteins (IRS2) by Origin

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More Proteins for IRS2 Interaction Partners

Zebrafish Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. Data show that JNK3 (show MAPK10 Proteins) silencing strongly decreases Insulin Receptor Substrate 2 (IRS2) protein expression.

Human Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. Findings suggest that insulin receptor substrate -1 (show IRS1 Proteins) Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (show INSR Proteins) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

  2. In the renal proximal tubule, insulin (show INS Proteins) signaling via IRS1 (show IRS1 Proteins) is inhibited, while insulin (show INS Proteins) signaling via IRS2 is preserved. Insulin (show INS Proteins) signaling via IRS2 continues to stimulate sodium reabsorption in the proximal tubule and causes sodium retention, edema, and hypertension.

  3. miRNA-146a may function as a useful clinical tool in the treatment and diagnosis of ESCC, and its overexpression suppressed cell growth through inhibition of IRS2.

  4. High IRS2 expression is associated with myeloproliferative neoplasms.

  5. FSH (show BRD2 Proteins) decreases IRS-2 mRNA degradation indicating post-transcriptional stabilization.

  6. These data demonstrate for the first time that miR146a suppresses lung cancer progression by repressing IRS2 expression

  7. IRS (show IARS Proteins)-specific gene signatures represent accurate surrogates of IGF activity and could predict response to anti-IGF therapy in breast cancer.

  8. Amplification of CUL4A (show CUL4A Proteins), IRS2, and TFDP1 (show TFDP1 Proteins) genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma.

  9. These results indicate that miR (show MLXIP Proteins)-106a* affects renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) progression by targeting IRS-2 with suppression of the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway in RCC (show XRCC1 Proteins) cells

  10. meta-analysis of genetic association studies: Data suggest that the D allele of the G1057D SNP in IRS2 has a significant effect on reducing risk of type 2 diabetes mellitus; obesity is a modifier of this association. [META-ANALYSIS, REVIEW]

Mouse (Murine) Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. Acute knockdown of Insr (show INSR Proteins) or both Irs1 (show IRS1 Proteins) and Irs2 in adipocytes increased Adipoq (show ADIPOQ Proteins) mRNA expression but reduced adiponectin (show ADIPOQ Proteins) secretion.

  2. Combination of DPP-4 (show DPP4 Proteins) inhibitor and PPARgamma (show PPARG Proteins) agonist exerts protective effects on pancreatic beta-cells in diabetic db/db (show LEPR Proteins) mice through the augmentation of IRS-2 expression

  3. discovered that Irs2 deficiency causes insulin resistance through up-regulation of the phosphatase and tensin homolog (PTEN). Importantly, suppressing PTEN in Irs2(-/-) podocytes rescued insulin sensitivity

  4. A knockout mouse has confirmed the importance of IRS2 in the control of glucose homeostasis and especially in the survival and function of pancreatic beta-cells.

  5. The data suggest that Irs2 deletion in endothelial cells leads to a decreased islet blood flow, which may cause impaired glucose-induced insulin (show INS Proteins) secretion.

  6. Results indicate that although IRS (show IARS Proteins) isoforms (irs1 (show IRS1 Proteins) and irs2) play divergent roles in the developmental regulation of cardiac size, these isoforms exhibit nonredundant roles in mediating the hypertrophic and metabolic response of the heart to exercise.

  7. Inhibition of Gsk-3beta by Irs-2-dependent PI3K signaling promotes glucose uptake and aerobic glycolysis.

  8. Data (including data from knockout mice) suggest that Irs2 is not required for islet beta-cell proliferation (as seen with high-fat diet) but may be needed for beta-cell regeneration (as seen after partial pancreatectomy).

  9. IRS2 plays a critical role in testicular development, potentially by mediating IGF1 (show IGF1 Proteins) signaling during embryonic and early postnatal development.

  10. Mice with combined cardiomyocyte-specific deletion of Irs1 & Irs2 (show IRS1 Proteins) had unrestrained autophagy in cardiomyocytes, leading to myocyte loss, heart failure, premature death, apoptosis & mitochondrial dysfunction.

Cow (Bovine) Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. The study identified the serine phosphorylation (p-Ser (show SIGLEC1 Proteins)) sites induced by PKC-Beta (show PRKCB Proteins) activation or AGT (show AGT Proteins), which inhibits insulin (show INS Proteins)-induced p-Tyr (show TYR Proteins) sites on IRS2 and its signals in endothelial cells.

IRS2 Protein Profile

Protein Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

Alternative names and synonyms associated with IRS2

  • insulin receptor substrate 2 (IRS2)
  • zgc:56306 (zgc:56306)
  • insulin receptor substrate 2 (irs2)
  • insulin receptor substrate 2 (Irs2)
  • 4PS protein
  • Irs-2 protein
  • IRS2 protein
  • si:dkeyp-24d6.1 protein

Protein level used designations for IRS2

insulin receptor substrate 2 , tyrosine kinase substrate , 4PS

100146249 Equus caballus
393285 Danio rerio
452657 Pan troglodytes
572001 Danio rerio
8660 Homo sapiens
29376 Rattus norvegicus
384783 Mus musculus
100730395 Cavia porcellus
485548 Canis lupus familiaris
100300012 Bos taurus
428017 Gallus gallus
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