Browse our ITPR1 Proteins (ITPR1)

Full name:
Inositol 1,4,5-Trisphosphate Receptor, Type 1 Proteins (ITPR1)
On are 5 Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) Proteins from 2 different suppliers available. Additionally we are shipping ITPR1 Antibodies (62) and ITPR1 Kits (1) and many more products for this protein. A total of 68 ITPR1 products are currently listed.
D6Pas2, ENSMUSG00000072853, Gm10429, I145TR, InsP3R, INSP3R1, IP3R, IP3R1, Itpr-1, opt, P400, Pcp-1, Pcp1, SCA15, SCA16, SCA29
list all proteins Gene Name GeneID UniProt
ITPR1 16438 P11881
Rat ITPR1 ITPR1 25262 P29994
ITPR1 3708 Q14643

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ITPR1 Proteins (ITPR1) by Origin

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Top referenced ITPR1 Proteins

  1. Human ITPR1 Protein expressed in Wheat germ - ABIN1308255 : Jarius, Wandinger, Horn, Heuer, Wildemann: A new Purkinje cell antibody (anti-Ca) associated with subacute cerebellar ataxia: immunological characterization. in Journal of neuroinflammation 2010 (PubMed)

More Proteins for ITPR1 Interaction Partners

Mouse (Murine) Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) interaction partners

  1. Cone-specific gene deletion of the inositol-1,4,5-trisphosphate receptor type I (IP3R1) also significantly increased cone density in the CNG (show CNGA1 Proteins)-channel-deficient mice, suggesting that IP3R1 signaling contributes to Ca(2 (show CA2 Proteins)+) homeostasis and cone survival.

  2. Pathological mutations of ITPR1 (inositol 1,4,5-trisphosphate receptor, type 1) were found in seven patients from four families all localized in the IRBIT (show AHCYL1 Proteins) (inositol triphosphate receptor binding protein) domain.

  3. The results suggest that IP3R1 and IP3R3 (show ITPR3 Proteins) are required for extra-embryonic vascularization in the placenta, allantois, and yolk sac (show ADCY10 Proteins).

  4. The results show that phosphorylations by Cdk1 (show CDK1 Proteins) and MAPK (show MAPK1 Proteins) enhance the activity of IP3R1, which is consistent with its maximal activity observed at the time of fertilization and the role of Ca(2 (show CA2 Proteins)+) release in egg activation.

  5. data indicate that PTPalpha (show PTPRA Proteins) and FAK (show PTK2 Proteins), which are enriched in FAs (show FAS Proteins), interact with IP3R1 at adjacent ER sites to spatially sequester IL-1 (show IL1A Proteins)-induced Ca(2 (show CA2 Proteins)+) signalling

  6. IGF-1 (show IGF1 Proteins) strengthens the interaction between NCS-1 (show NCS1 Proteins) and IP3R in the process of regulation of nuclear Ca2 (show CA2 Proteins)+ signaling in cardiomyocytes.

  7. Car8 (show CA8 Proteins) regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.

  8. cGMP/protein kinase (show CDK7 Proteins) G signaling suppresses Itpr1 phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3 (show CNGA3 Proteins)-deficient mice.

  9. Association of SLAT (show DEF6 Proteins) with IP receptor 1 promotes Ca(2 (show CA2 Proteins)) signaling in T cells.

  10. IP3R-mediated Ca2 (show CA2 Proteins)+ signaling reinforces Tcf-1 (show HNF1A Proteins) activity to both ensure normal development and to prevent thymocyte neoplasia.

Human Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) interaction partners

  1. Homozygous ITPR1 missense variant [c.5360T>C; p.(L1787P)] segregated with cerebellar hypoplasia. Heterozygous carriers were asymptomatic.

  2. increased mitochondrial calcium due to the gain-of-function enhancement of IP3R channels in the cells expressing PS1 (show PSEN1 Proteins)-M146L leads to the opening of permeability transition pore in high conductance state.

  3. Data suggest that ADRB2 (beta2 adrenergic receptor) activation (as illustrated by epinephrine and nor epinephrine) leads to robust calcium ion mobilization from intracellular stores in endoplasmic reticulum via activation of phosphoinositide phospholipase C (PLC) and opening of inositol trisphosphate receptor (IP3R).

  4. Data indicate that unlike ryanodine receptor RyRs, inositol 145-trisphosphate receptor IP3Rs are present and continually functional at early stages of cardiomyocyte differentiation.

  5. ITPR1 is the SCA15 causative gene.

  6. results demonstrate biallelic and monoallelic ITPR1 mutations as the underlying genetic defects for Gillespie syndrome, further extending the spectrum of ITPR1-related diseases

  7. Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome.

  8. Studies indicate that four IP3-binding sites within the tetrameric inositol 1,4,5-trisphosphate receptors (IP3Rs) must bind inositol 145-trisphosphate (IP3) before the channel can open for intracellular Ca2 (show CA2 Proteins)+ signals.

  9. Data show that inositol 145-trisphosphate receptor type 1 (IP3R1) -with a single inositol 145-trisphosphate (IP3) binding-deficient subunit lack activity.

  10. SNPs in ITPR1 and CNTN4 (show CNTN4 Proteins) are involved in the regulation of serum uric acid concentrations in Mexican Americans

Cow (Bovine) Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) interaction partners

  1. STIM1 (show STIM1 Proteins) and STIM2 (show Stim2 Proteins) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1.

  2. we propose a model in which the partial unfolding of the suppressor domain by apo (show C9orf3 Proteins)-CaM (show KRIT1 Proteins) and the stepwise binding of the N lobe (show LTF Proteins) of CaM (show KRIT1 Proteins) to the suppressor domain are important elements of calcium/CaM (show KRIT1 Proteins) inhibition of IP(3)R

  3. structural mapping of the amino acid sequences to several functional domains is deduced within the structure of the InsP3R1 tetramer

  4. the InsP3R/Ca2 (show CA2 Proteins)+ channel is regulated by chromogranin B (show CHGB Proteins)

  5. the redox potential and Ca(2 (show CA2 Proteins)+) can regulate IP(3)R through totally different mechanisms: Ca(2 (show CA2 Proteins)+) by the indirect effect and the redox potential by direct action causing conformational changes

ITPR1 Protein Profile

Protein Summary

This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene.

Alternative names and synonyms associated with ITPR1

  • inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1)
  • inositol 1,4,5-trisphosphate receptor 1 (Itpr1)
  • inositol 1,4,5-trisphosphate receptor, type 1 (Itpr1)
  • D6Pas2 protein
  • ENSMUSG00000072853 protein
  • Gm10429 protein
  • I145TR protein
  • InsP3R protein
  • INSP3R1 protein
  • IP3R protein
  • IP3R1 protein
  • Itpr-1 protein
  • opt protein
  • P400 protein
  • Pcp-1 protein
  • Pcp1 protein
  • SCA15 protein
  • SCA16 protein
  • SCA29 protein

Protein level used designations for ITPR1

inositol 1,4,5-triphosphate receptor, type 1 , type I inositol triphosphate receptor , IP3 receptor , IP3R 1 , InsP3R type I , InsP>3

395412 Gallus gallus
476548 Canis lupus familiaris
100052808 Equus caballus
16438 Mus musculus
25262 Rattus norvegicus
3708 Homo sapiens
317697 Bos taurus
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