Browse our anti-Klotho (KL) Antibodies

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anti-Klotho Antibodies (KL)
On are 89 Klotho (KL) Antibodies from 19 different suppliers available. Additionally we are shipping Klotho Kits (49) and Klotho Proteins (12) and many more products for this protein. A total of 164 Klotho products are currently listed.
alpha-kl, Kitl, KL, LOC100223456

Most Popular Reactivities for anti-Klotho (KL) Antibodies

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anti-Human Antibodies:

anti-Mouse (Murine) Antibodies:

anti-Rat (Rattus) Antibodies:

All available anti-Klotho Antibodies

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Top referenced anti-Klotho Antibodies

  1. Human Polyclonal KL Primary Antibody for FACS, WB - ABIN389493 : Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications. in Molecular & cellular proteomics : MCP 2007 (PubMed)
    Show all 2 references for 389493

  2. Human Polyclonal KL Primary Antibody for WB - ABIN4890528 : Chen, Gould, Garza, Gao, Hampton, Newton: Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. in The Journal of biological chemistry 2007 (PubMed)

  3. Human Polyclonal KL Primary Antibody for ELISA - ABIN450061 : Chen, Podvin, Gillespie, Leeman, Abraham: Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)

  4. Human Polyclonal KL Primary Antibody for IHC (p), IHC - ABIN250843 : Kurosu, Yamamoto, Clark, Pastor, Nandi, Gurnani, McGuinness, Chikuda, Yamaguchi, Kawaguchi, Shimomura, Takayama, Herz, Kahn, Rosenblatt, Kuro-o: Suppression of aging in mice by the hormone Klotho. in Science (New York, N.Y.) 2005 (PubMed)

  5. Human Polyclonal KL Primary Antibody for ELISA, ICC - ABIN4329242 : Manrique, Habibi, Aroor, Sowers, Jia, Hayden, Garro, Martinez-Lemus, Ramirez-Perez, Klein, Meininger, DeMarco: Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice. in Cardiovascular diabetology 2016 (PubMed)

More Antibodies against Klotho Interaction Partners

Human Klotho (KL) interaction partners

  1. disruption of the FGF23 (show FGF23 Antibodies)-Klotho system causes phosphate retention and a syndrome resembling aging in mammals has led to the notion that phosphate accelerates aging--{REVIEW}

  2. A factor for functioning of the brain in aged is KLOTHO gene.

  3. Data suggest Klotho attenuates ox-LDL- (oxidized low density lipoprotein)-induced oxidative stress in vascular endothelial cells via up-regulation of oxidative scavengers (lipoprotein and nitric oxide), activation of the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/eNOS (show NOS3 Antibodies) signaling, and down-regulation of LOX1 (show OLR1 Antibodies) (lectin-like ox-LDL receptor (show LDLR Antibodies)) expression. (PI3K (show PIK3CA Antibodies) = phosphatidylinositol 3-Kinase; Akt (show AKT1 Antibodies) = proto-oncogene c-Akt (show AKT1 Antibodies); eNOS (show NOS3 Antibodies) = endothelial nitric oxide synthase (show NOS3 Antibodies))

  4. association between alpha-Klotho and cardiac hypertrophy and systolic dysfunction was significant only among patients with CKD G3b and G3a (show APOM Antibodies), respectively

  5. Targeting klotho may thus represent a therapeutic strategy .

  6. FGF23 (show FGF23 Antibodies) affected NO synthesis and oxidative stress in human coronary artery endothelial cells are modulated by Klotho.

  7. Conversely, siRNA-mediated Klotho silencing up-regulated Egr-1 (show EGR1 Antibodies), FN, and Col (show HDAC1 Antibodies) I expression and the p-Smad3/Smad3 (show SMAD3 Antibodies) ratio. Moreover, the effects of si-Klotho on Egr-1 (show EGR1 Antibodies) expression were abolished by the TGF-beta1 (show TGFB1 Antibodies) inhibitor SB-431542. Klotho overexpression can prevent mesangial ECM (show MMRN1 Antibodies) production in high-glucose-treated human MCs (show SMCP Antibodies), an effect that has been partially attributed to Egr-1 (show EGR1 Antibodies) down-regulation facilitated by TGF-beta1 (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) s...

  8. Klotho levels were higher in acute kidney injury patients and females and lower in end stage renal disease patients than in healthy adults and patients with moderate chronic kidney disease.

  9. Genetic polymorphisms such as the G-395A polymorphism in the promoter region of the Klotho gene have been associated with the development of essential hypertension.

  10. Secreted and cleaved sKlotho and FGF23 (show FGF23 Antibodies) are detected in CSF (show CSF2 Antibodies) and plasma, and the protein levels are significantly higher in plasma in children with suspected CNS disease

Mouse (Murine) Klotho (KL) interaction partners

  1. Data show that Klotho protein is present in the heart, and reduced levels of myocardial Klotho in aging mice is accompanied by lower levels heat shock protein 70 (HSP70 (show HSP70 Antibodies)) in the myocardium.

  2. Klotho preserves AEC mtDNA integrity in the setting of oxidative stress necessary for preventing apoptosis and asbestos-induced lung fibrosis.

  3. epigenetic silencing of klotho during muscular dystrophy contributes substantially to lost regenerative capacity and increased fibrosis of dystrophic muscle during late progressive stages of the disease.

  4. Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Antibodies)-RUNX2 (show RUNX2 Antibodies) pathway.

  5. The effects were abolished by using pharmacological inhibition of PI3K/Akt (show AKT1 Antibodies) with LY294002 and paralleled by transfecting DCs with klotho siRNA. In conclusion, the regulation of klotho sensitive DC function by IGF-1 (show IGF1 Antibodies) or insulin (show INS Antibodies) is mediated through PI3K/Akt (show AKT1 Antibodies) signaling pathway in BMDCs.

  6. Klotho can modulate inflammation via PDLIM2 (show PDLIM2 Antibodies)/NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) pathway in cyclosporine A-induced nephropathy.

  7. the histological malformation in periodontal tissues in alphaKlotho-deficient mice appears to be due to not only increased concentration of inorganic phosphate but also disrupted alphaklotho/FGF23 (show FGF23 Antibodies) signaling

  8. Results show that Klotho regulates adrenal CYP11B2 (show CYP11B2 Antibodies) expression. Klotho deficiency-induced spontaneous hypertension and kidney damage may be partially attributed to the upregulation of CYP11B2 (show CYP11B2 Antibodies) expression and aldosterone synthesis.

  9. Aberrant Klotho expression contributes to systemic chronic inflammation in Klotho-/- mice.

  10. Thus, higher levels of FGF23 (show FGF23 Antibodies) in kl/kl mouse may have a role to increase TNF-alpha (show TNF Antibodies) production in would lesion independently of alpha-Klotho protein, and impair granulation formation and delay wound healing.

Pig (Porcine) Klotho (KL) interaction partners

  1. Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Antibodies)-RUNX2 (show RUNX2 Antibodies) pathway.

  2. significant expression of FGF23 (show FGF23 Antibodies) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Antibodies) in chondrocyte differentiation and tissue mineralization.

Klotho (KL) Antigen Profile

Antigen Summary

This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.

Alternative names and synonyms associated with Klotho (KL)

  • klotho (KL) antibody
  • klotho (LOC100223456) antibody
  • klotho (kl) antibody
  • klotho (LOC100533542) antibody
  • klotho (Kl) antibody
  • Klotho (Kl) antibody
  • Klotho-like (LOC100356074) antibody
  • alpha-kl antibody
  • Kitl antibody
  • KL antibody
  • LOC100223456 antibody

Protein level used designations for anti-Klotho (KL) Antibodies

klotho , kit ligand , secreted form of Klotho protein

467257 Pan troglodytes
100009028 Oryctolagus cuniculus
100223456 Taeniopygia guttata
100490988 Xenopus (Silurana) tropicalis
100533542 Aplysia californica
9365 Homo sapiens
16591 Mus musculus
83504 Rattus norvegicus
100685604 Canis lupus familiaris
100519728 Sus scrofa
784635 Bos taurus
100714519 Cavia porcellus
418909 Gallus gallus
101110249 Ovis aries
100356074 Oryctolagus cuniculus
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