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Human Polyclonal KL Primary Antibody for WB - ABIN2774619
Chen, Gould, Garza, Gao, Hampton, Newton: Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. in The Journal of biological chemistry 2007
Human Polyclonal KL Primary Antibody for IHC (p), IHC - ABIN250843
Kurosu, Yamamoto, Clark, Pastor, Nandi, Gurnani, McGuinness, Chikuda, Yamaguchi, Kawaguchi, Shimomura, Takayama, Herz, Kahn, Rosenblatt, Kuro-o: Suppression of aging in mice by the hormone Klotho. in Science (New York, N.Y.) 2005
Human Polyclonal KL Primary Antibody for EIA, IF - ABIN783343
Kuro-o, Matsumura, Aizawa, Kawaguchi, Suga, Utsugi, Ohyama, Kurabayashi, Kaname, Kume, Iwasaki, Iida, Shiraki-Iida, Nishikawa, Nagai, Nabeshima: Mutation of the mouse klotho gene leads to a syndrome resembling ageing. in Nature 1997
Results show that Klotho is expressed in skeletal muscle and levels are reduced by smoking.
The expression levels of Klotho and autophagy are decreased in drug-resistant lung cancer cells.
Overexpression of miR (show MLXIP Antibodies)-199b-5p canceled the effects of atrasentan on klotho expression and apoptosis of renal tubular cells in both in vivo and in vitro.
The influence of Klotho gene variants on Klotho gene expression levels in human vascular tissue and their association with cardiovascular disease and cardiovascular risk factors.
This study showed that serum Klotho concentration tends to be higher in MS patients when compared to control group.
Overexpression of klotho is associated with breast cancer.
Klotho mRNA and protein levels were reduced in preeclamptic placentas compared with controls. -744delA single-nucleotide polymorphism was significantly associated with preeclampsia.
These results suggest that free klotho mediates the FGF23 (show FGF23 Antibodies)-induced inhibition of 1,25VD synthesis.
Data suggest that down-regulation of serum Klotho level may play role in development of atherosclerosis and endothelial dysfunction in subjects with type 1 diabetes.
The data suggest that secreted Klotho protein attenuates the osteogenic differentiation of human bone marrow mesenchymal stem cells in vitro through FGFR1 (show FGFR1 Antibodies)/ERK (show EPHB2 Antibodies) signaling.
FGF23 (show FGF23 Antibodies) regulates osteopontin (show SPP1 Antibodies) secretion indirectly by suppressing alkaline phosphatase transcription and phosphate production in osteoblastic cells, acting through FGF receptor-3 (show FGFR3 Antibodies) in a Klotho-independent manner
Inhibition of mTOR (show FRAP1 Antibodies) signaling ameliorates vascular calcification via Klotho upregulation.
Klotho deficiency promoted HFD-induced arterial stiffening and hypertension via downregulation of AMPKalpha (show GRK4 Antibodies) activity.
level of spontaneous remyelination was increased approximately two-fold in Klotho-overexpressing mice following cuprizone-induced demyelination.
data highlight the importance of ASK1 (show MAP3K5 Antibodies)/p38 MAPK (show MAPK14 Antibodies) pathway in the brain and identify Klotho as a possible anti-oxidant effector
Klotho ameliorates kidney injury and fibrosis and normalizes blood pressure by targeting the renin (show REN Antibodies)-angiotensin system.
Injection of klotho protein results in hematopoietic changes opposite to the ones observed in Klotho(-/-) mice.
Sodium bicarbonate administration has a favorable influence on vascular calcification and early death of klotho-deficient mice.
Data suggest that the level of expression of Klotho in pancreatic beta-cells regulates apoptosis; low expression (halplodeficiency of Klotho) promotes apoptosis/type 1 diabetes; beta-cell-specific overexpression prevents apoptosis/type 1 diabetes.
significant expression of FGF23 (show FGF23 Antibodies) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Antibodies) in chondrocyte differentiation and tissue mineralization.
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
, kit ligand
, secreted form of Klotho protein