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Browse our PDGFRB Proteins (PDGFRB)

Full name:
Platelet-Derived Growth Factor Receptor, beta Polypeptide Proteins (PDGFRB)
On are 37 Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) Proteins from 14 different suppliers available. Additionally we are shipping PDGFRB Antibodies (547) and PDGFRB Kits (37) and many more products for this protein. A total of 661 PDGFRB products are currently listed.
AI528809, CD140B, IBGC4, JTK12, PDGFR, PDGFR-1, PDGFR1
list all proteins Gene Name GeneID UniProt
PDGFRB 18596 P05622
PDGFRB 24629 Q05030
PDGFRB 5159 P09619

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PDGFRB Proteins (PDGFRB) by Origin

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Top referenced PDGFRB Proteins

  1. Human PDGFRB Protein expressed in Human Cells - ABIN2002983 : Chi, McPhee, Wagner, Dietz, Pantazis, Goustin: Integration of proviral DNA into the PDGF beta-receptor gene in HTLV-I-infected T-cells results in a novel tyrosine kinase product with transforming activity. in Oncogene 1997 (PubMed)
    Show all 4 references for ABIN2002983

  2. Cynomolgus PDGFRB Protein expressed in Human Cells - ABIN2010002 : Arcaro, Zvelebil, Wallasch, Ullrich, Waterfield, Domin: Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. in Molecular and cellular biology 2000 (PubMed)
    Show all 4 references for ABIN2010002

  3. Rat (Rattus) PDGFRB Protein expressed in Human Cells - ABIN2009522 : Zhang, Henzel: Signal peptide prediction based on analysis of experimentally verified cleavage sites. in Protein science : a publication of the Protein Society 2004 (PubMed)
    Show all 4 references for ABIN2009522

  4. Human PDGFRB Protein expressed in Human Cells - ABIN2002985 : Morerio, Acquila, Rosanda, Rapella, Dufour, Locatelli, Maserati, Pasquali, Panarello: HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2). in Cancer research 2004 (PubMed)
    Show all 4 references for ABIN2002985

  5. Human PDGFRB Protein expressed in HEK-293 Cells - ABIN2181629 : Golub, Barker, Lovett, Gilliland: Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. in Cell 1994 (PubMed)
    Show all 3 references for ABIN2181629

More Proteins for PDGFRB Interaction Partners

Mouse (Murine) Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) interaction partners

  1. Data show that oligodendrocyte transcription factor 2 (Olig2 (show OLIG2 Proteins)) deletion causes platelet-derived growth factor receptor (PDGFR) downregulation and reciprocal epidermal growth factor receptor (EGFR (show EGFR Proteins)) upregulation.

  2. Decreased expression of PDGFR-beta in vascular smooth muscle cells was associated with thrombosis in vivo.

  3. Our results highlight the need for careful interpretation of lineage tracing using constitutive Cre lines that cannot discriminate active from historical expression. The early vascular targeting by the Pdgfrb-Cre also warrants consideration for its use in studies of mural cells

  4. Pdgfrbeta(+) cells do not significantly contribute to the initial cold-induced recruitment of beige adipocytes in WAT; it is only after prolonged cold exposure that these cells differentiate into beige adipocytes.

  5. Results suggested that increased bFGF (show FGF2 Proteins) upregulates the expression of PDGFRbeta and may enhance PDGFRbeta-mediated pericyte functions after brain ischemia

  6. Laminin regulates PDGFRbeta cell differentiation, fate determination, cell stemness and muscle development via gpihbp1 (show GPIHBP1 Proteins).

  7. The role of the S1PR3 (show S1PR3 Proteins)/PDGFR-beta/Akt (show AKT1 Proteins) pathway in sphingosine-1-phosphate -induced endothelial progenitor cells migration and angiogenesis

  8. loss-of-function mutations in PDGFB (show PDGFB Proteins) or PDGFRB cause Primary Familial Brain Calcification.

  9. PDGF (show PDGFA Proteins) signalling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation.

  10. This study demonstrated that PDGFRbeta-expressing cells appear to arise from vascular wall pericytes in peri (show POSTN Proteins)-infarct areas and then extend toward the ischemic core while producing ECM (show MMRN1 Proteins) proteins, fibronectin (show FN1 Proteins) and collagen type I, after MCAO.

Human Platelet-Derived Growth Factor Receptor, beta Polypeptide (PDGFRB) interaction partners

  1. There are two platelet-derived growth factor receptor (PDGFR) genes (PDGFRA (show PDGFRA Proteins) and PDGFRB), and they reside on chromosome 4 and 5.

  2. that a loss of KAI1/CD82 (show CD82 Proteins) and an increase in PDGFR expression in gliomas relate to a progressive tumor growth

  3. PDGFR-positive myeloid neoplasms are rare. Marked leukocytosis with marked eosinophilia has been rarely described in myeloid neoplasms associated with PDGFR rearrangement.

  4. Stromal expression of PDGFRbeta increased with increasing histologic grade of breast phyllodes tumor. PDGFR stromal positivity was associated with shorter overall survival.

  5. The expression level of PDGFRB in glioblastoma multiforme pericytes from the microvascular proliferation was significantly higher than that in GBM tumor cells. miRNAs targeting PDGFRB were downregulated in microvascular proliferation.

  6. The simultaneous action of PDGF-B (show PDGFB Proteins)/PDGFRbeta and VEGF165b on the same type of receptor may explain the resistance to antiangiogenic therapy, which depends on the degree of modulation of PDGFRbeta phosphorylation.

  7. PDGFRB gene rearrangement is associated with transformation from atypical chronic myeloid leukemia (show BCL11A Proteins) to chronic myelomonocytic leukemia.

  8. Results suggested that increased bFGF (show FGF2 Proteins) upregulates the expression of PDGFRbeta and may enhance PDGFRbeta-mediated pericyte functions after brain ischemia

  9. Data suggest that cross-talk between PDGFb (show PDGFB Proteins)-dependent beta-catenin (show CTNNB1 Proteins) activation and Wnt (show WNT2 Proteins) signaling increases pulmonary artery smooth muscle cell proliferation in idiopathic pulmonary arterial hypertension; proliferation is not increased in normal cells.

  10. The KIT and PDGFRB mutations were predicted to be pathogenic using in silico analysis, whereas the ERBB2 (show ERBB2 Proteins) mutation was predicted to be benign.. the patient was treated with pazopanib and achieved a partial response that lasted for 7.5 months

PDGFRB Protein Profile

Protein Summary

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor\; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Alternative names and synonyms associated with PDGFRB

  • platelet derived growth factor receptor, beta polypeptide (Pdgfrb)
  • platelet-derived growth factor receptor, beta polypeptide (PDGFRB)
  • AI528809 protein
  • CD140B protein
  • IBGC4 protein
  • JTK12 protein
  • PDGFR protein
  • PDGFR-1 protein
  • PDGFR1 protein

Protein level used designations for PDGFRB

CD140 antigen-like family member B , PDGF beta chain , PDGF-R-beta , PDGFR-beta , beta platelet-derived growth factor receptor , beta-type platelet-derived growth factor receptor , platelet-derived growth factor receptor 1 , platelet-derived growth factor receptor beta , platelet-derived growth factor receptor beta variant 1 , Platelet-derived growth factor receptor, beta , protein tyrosin kinase

18596 Mus musculus
24629 Rattus norvegicus
5159 Homo sapiens
442985 Canis lupus familiaris
770488 Gallus gallus
100342872 Oryctolagus cuniculus
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