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The results provide functional evidence that elevated PDGFRbeta signaling causes tissue wasting or overgrowth reminiscent of human genetic syndromes and that the STAT1 (show STAT1 Proteins) pathway is a crucial modulator of this phenotypic spectrum.
Identify PDGFRbeta as a driver in activating Akt (show AKT1 Proteins)/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.
Data show that three platelet-derived growth factor receptor beta (PDGFRB) mutants (R561C, P660T and N666K) were able to transform NIH3T3 and Ba/F3 cells to different extents.
data therefore collectively suggest that upon TGFbeta (show TGFB1 Proteins) stimulation, SP1 (show SP1 Proteins) recruits SMAD2 (show SMAD2 Proteins) to the promoter of Pdgfrb to up-regulate its expression and thus Pdgfrb is a direct downstream target of the TGFbeta (show TGFB1 Proteins)/SMAD2 (show SMAD2 Proteins) signaling
PdgfrbetaF7/F7 mice between 4-6 and 36-48 weeks of age developed a region-dependent loss in pericyte coverage (22-46, 24-44 and 4-31%) and cell numbers (36-49, 34-64 and 11-36%), reduction in capillary length (20-39, 13-46 and 1-30%), and an increase in extravascular fibrinogen-derived deposits (3.4-5.2, 2.8-4.1 and 0-3.6-fold) demonstrating BBB breakdown in the cortex, hippocampus and thalamus, respectively.
PDGF-B (show PDGFB Proteins)-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization.
there is great possibility that EPCs overexpressing PDGFR-beta enhanc VSMC apoptosis and suppress VSMC migration by competitive consumption of PDGF (show PDGFA Proteins)-BB in the early phase after carotid artery injury in mice.
PDGFRalpha and PDGFRbeta are coexpressed in the craniofacial mesenchyme of mid-gestation mouse embryos and that ablation of Pdgfrb in the neural crest lineage results in increased nasal septum width, delayed palatal shelf development, and subepidermal blebbing.
The results from this study indicate that PDGF (show PDGFA Proteins) signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.
Data show that oligodendrocyte transcription factor 2 (Olig2 (show OLIG2 Proteins)) deletion causes platelet-derived growth factor receptor (PDGFR) downregulation and reciprocal epidermal growth factor receptor (EGFR (show EGFR Proteins)) upregulation.
Suggest the association of activation of Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) pathway proteins and PDGFR-beta in fibrosarcomatous transformation of dermatofibrosarcoma protuberans.
High PDGFRB expression is associated with gastric cancer.
Authors identified gain-of-function PDGFRB mutations in the majority of multifocal infantile myofibromatosis cases, shedding light on the mechanism of disease development, which is reminiscent of multifocal venous malformations induced by TIE2 (show TEK Proteins) mutations.
findings not only confirm the important role of R853 in establishing the resistant phenotype of the mutant NDEL1 (show NDEL1 Proteins)-PDGFRB, but also underline the potential of protein modelling for prediction of sensitivity and resistance to TKI treatment.
A novel mutation in PDGFRB [NM_002609.3:c.1699A > G, p.Lys567Glu] was identified in infantile myofibromatosis patients.
Higher expression of PDGFR-Beta is related to more serious dural penetration of clival chordomas.
Targeted next-generation DNA sequencing identified PDGFRB alterations in all cases of myopericytomatosis and conventional myopericytoma tested (5 cases each), including mutations in 4 cases of myopericytomatosis (N666K in 3; Y562-R565 deletion in 1 case) and 3 myopericytomas (Y562C, K653E, and splice acceptor deletion in 1 case each), as well as low-level PDGFRB amplification in 2 cases of myopericytomatosis and 4 myoperi
Elevated PDGFRB expression was noted in 20.7% of patients with papillary renal cell carcinoma (show MOK Proteins).
Imatinib in myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB in chronic or blast phase
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor\; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
CD140 antigen-like family member B
, PDGF beta chain
, beta platelet-derived growth factor receptor
, beta-type platelet-derived growth factor receptor
, platelet-derived growth factor receptor 1
, platelet-derived growth factor receptor beta
, platelet-derived growth factor receptor beta variant 1
, Platelet-derived growth factor receptor, beta
, protein tyrosin kinase