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RICTOR amplification may define a novel and unique molecular subset of patients with lung cancer who may benefit from treatment with mTORC1/2 inhibitors.
Data show that rapamycin-insensitive companion of mTOR protein (RICTOR) plays a central role in phosphatidylinositol 3-kinase (PI3K (show PIK3CA ELISA Kits))/proto-oncogene (show RAB1A ELISA Kits) protein c (show PROC ELISA Kits)-akt (AKT (show AKT1 ELISA Kits)) pathway in melanocytes and its deregulation could be involved in melanoma development.
Mdm20 (show NAA25 ELISA Kits) acts as a novel regulator of Rictor, thereby controlling mTORC2 (show CRTC2 ELISA Kits) activity, and leading to the activation of PKCalphaS657 and FoxO1 (show FOXO1 ELISA Kits).
RICTOR/MTORC2 (show CRTC2 ELISA Kits)-AKT (show AKT1 ELISA Kits) can integrate convergent hormonal and metabolic signals to provide coordinated and sensitive regulation of hepatic FOXO1 (show FOXO1 ELISA Kits)-target gene expression.
the expressions of Beclin1 (show BECN1 ELISA Kits), Raptor (show RPTOR ELISA Kits), and Rictor are related to the development and progression of colorectal carcinoma and multidrug resistance.
A new dimension in mTOR (show FRAP1 ELISA Kits)-rictor relationship.
phosphorylation of Rictor at Ser1162 by Plk1 (show PLK1 ELISA Kits) might be involved in a novel signaling pathway.
results suggest that mTORC2 (show CRTC2 ELISA Kits)/Rictor/pAkt (show AKT1 ELISA Kits) may play a more important role than mTORC1/pS6 in tumor progression, which could act as a prognostic biomarker or potential therapeutic target in gastric cancer
glucose-dependent acetylation of Rictor, a central component of mechanistic target of rapamycin (show FRAP1 ELISA Kits) complex 2 (mTORC2 (show CRTC2 ELISA Kits)), promotes tumor growth and resistance to epidermal growth factor receptor (EGFR (show EGFR ELISA Kits))-, PI3K (show PIK3CA ELISA Kits)-, and AKT (show AKT1 ELISA Kits)-targeted therapies
analysis of how Rictor undergoes GSK3-dependent, FBXW7 (show FBXW7 ELISA Kits)-mediated ubiquitination and proteasomal degradation
analysis of mTORC2 (show CRTC2 ELISA Kits) components mTOR (show FRAP1 ELISA Kits), Rictor and mSin1 reveals diurnal variation in mouse perivascular adipose tissue
Adipose tissue mTORC2 (show CRTC2 ELISA Kits) regulates via Rictor ChREBP (show MLXIPL ELISA Kits)-driven de novo lipogenesis and hepatic glucose metabolism.
Rictor is essential for the generation of type II IFN-dependent antiviral and antiproliferative responses and that it controls the generation of type II IFN-suppressive effects on normal and malignant hematopoiesis
Study suggests that Rictor/mTORC2 (show CRTC2 ELISA Kits) signaling activation mediates TGFbeta1 (show TGFB1 ELISA Kits)-induced fibroblast activation and contributes to the development of kidney fibrosis.
endogenous Rictor/mTORC2 (show CRTC2 ELISA Kits) protects against cisplatin-induced acute kidney injury, probably mediated by promoting cell survival through Akt (show AKT1 ELISA Kits) signaling activation and induction of autophagy
Together, these findings establish the importance of Rictor/mTORC2 (show CRTC2 ELISA Kits) signaling in Sertoli cell function and spermatogenesis through the maintenance of Sertoli cell cytoskeletal dynamics, BTB integrity, and cell polarity.
Rictor regulates the development of early B cells.
RICTOR/mTORC2 (show CRTC2 ELISA Kits) is important for interactions between vasculature, adipocytes, and brain to tune physiological outcomes, such as blood pressure and locomotor activity.
Rictor in Myf5 (show MYF5 ELISA Kits) lineage shifts BAT (show BAAT ELISA Kits) metabolism to a more oxidative and less lipogenic state and is required for lipognesis.
RICTOR and MTOR (FRAP1\; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004
rapamycin-insensitive companion of mTOR
, AVO3 homolog
, TORC2-specific protein AVO3
, protein pianissimo
, FYN binding protein
, rapamycin insensitive companion of mTOR