Browse our Spleen tyrosine Kinase Proteins (SYK)

On www.antibodies-online.com are 16 Spleen tyrosine Kinase (SYK) Proteins from 10 different suppliers available. Additionally we are shipping Spleen tyrosine Kinase Antibodies (380) and Spleen tyrosine Kinase Kits (49) and many more products for this protein. A total of 468 Spleen tyrosine Kinase products are currently listed.
Synonyms:
p72-Syk, p72syk, Sykb
list all proteins Gene Name GeneID UniProt
SYK 6850 P43405
SYK 20963 P48025
SYK 25155 Q64725

Spleen tyrosine Kinase Proteins (SYK) by Origin

More Proteins for Spleen tyrosine Kinase Interaction Partners

Human Spleen tyrosine Kinase (SYK) interaction partners

  1. study demonstrates that high SYK expression is a common feature of CD21 (show CR2 Proteins)(low) B cells independent of the underlying disorder, and that this high expression is sufficient to drive constitutive phosphorylation of SYK and its immediate targets Bruton's tyrosine kinase (show BTK Proteins) and phospholipase Cgamma2

  2. IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta (show IL1B Proteins) responses in a TLR2- and FcgammaR-dependent fashion. FcgammaR-mediated Syk activation leads to NLRP3 (show NLRP3 Proteins) inflammasome-dependent IL-1beta (show IL1B Proteins) production in macrophages.

  3. High SYK expression is associated with lymphangioleiomyomatosis.

  4. NKp65 (show KLRF2 Proteins) utilizes a hemi-immunoreceptor tyrosine-based activation motif -like motif for cellular activation that requires Syk, although Syk appears not to be recruited to NKp65 (show KLRF2 Proteins).

  5. Syk is a key regulator of Hoxa9 (show HOXA9 Proteins)/Meis1 (show MEIS1 Proteins)-driven acute myeloid leukemia (show BCL11A Proteins).

  6. Data show that spleen tyrosine kinase (SYK) and proto-oncogene (show RAB1A Proteins) protein c-akt (AKT1 (show AKT1 Proteins)) proteins were increased in the cytoplasm of the cells forming Mallory-Denk bodies.

  7. B cell receptor signaling component, SYK, caused PAX5 (show PAX5 Proteins) tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 (show PRDM1 Proteins) promoter by PAX5 (show PAX5 Proteins) was attenuated by this phosphorylation.

  8. Pharmacological inhibitors of SYK activity significantly reduced the engulfment of oxLDL microbeads in the presence of serum factors, but had little effect on IgG phagocytosis.

  9. our data strongly suggest that AQCA-mediated suppression of inflammatory responses could be managed by a direct interference of signaling cascades including IRAK (show IRAK1 Proteins) and Syk, linked to the activation of NF-kappaB (show NFKB1 Proteins) and AP-1 (show FOSB Proteins).

  10. a potential link between the upregulation of Syk and VEGF-C (show VEGFC Proteins) expression and lung adenocarcinoma.

Mouse (Murine) Spleen tyrosine Kinase (SYK) interaction partners

  1. ephrin B3 (show EFNB3 Proteins)/EphB2 (show EPHB2 Proteins) are obvious candidates for driving the Syk-dependent repulsive response.

  2. IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta (show IL1B Proteins) responses in a TLR2- and FcgammaR-dependent fashion. FcgammaR-mediated Syk activation leads to NLRP3 (show NLRP3 Proteins) inflammasome-dependent IL-1beta (show IL1B Proteins) production in macrophages.

  3. The effect of Smad4 (show SMAD4 Proteins) was at least partially mediated by the downstream effectors Syk and ROCK2 (show ROCK2 Proteins) transcription in megakaryocytes.

  4. Gene expression analysis of lung tissues revealed that HDM (show HDAC3 Proteins)-induced expression of IL-17 (show IL17A Proteins) and CXCL-1 (show CXCL1 Proteins) was significantly attenuated in both Sykdel/del and GSK143-treated mice. CONCLUSION: Syk inhibitors may play a role in the management of neutrophilic asthma

  5. collagen-I-mediated inhibition of proplatelet formation is specifically controlled by GPVI (show GP6 Proteins).

  6. Pharmacological Syk inhibition might provide a safe therapeutic strategy to prevent arterial thrombosis and to limit infarct progression in acute stroke.

  7. Studies indicate that SHP1 (show PTPN6 Proteins) and SYK crosstalk as a critical regulator of MyD88 (show MYD88 Proteins) post-translational modifications and IL-1 (show IL1A Proteins)-driven inflammation.

  8. dephosphorylation of Tyr (show TYR Proteins)(P)(346) may be considered an important "checkpoint" in the regulation of Syk activation process. Putative biological functions of TULA-2 (show STS1 Proteins)-mediated dephosphorylation of Tyr (show TYR Proteins)(P)(346) may include deactivation of receptor-activated Syk or suppression of Syk activation by suboptimal stimulation.

  9. These studies define a pathologic role for myeloid Syk signaling in renal ischemia/reperfusion injury

  10. Torreya nucifera butanol fraction exhibits anti-inflammatory activities by direct inhibition of macrophage Src (show SRC Proteins)/Syk/NF-kappaB (show NFKB1 Proteins) and IRAK1 (show IRAK1 Proteins)/AP-1 (show JUN Proteins) signaling.

Cow (Bovine) Spleen tyrosine Kinase (SYK) interaction partners

  1. These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.

Spleen tyrosine Kinase (SYK) Protein Profile

Protein Summary

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Spleen tyrosine Kinase (SYK)

  • Tyrosine-protein kinase SYK (ksyk)
  • spleen tyrosine kinase (SYK)
  • spleen tyrosine kinase (Syk)
  • p72-Syk protein
  • p72syk protein
  • Sykb protein

Protein level used designations for Spleen tyrosine Kinase Proteins (SYK)

Tyrosine-protein kinase SYK , tyrosine-protein kinase SYK , protein-tyrosine kinase

GENE ID SPECIES
100380388 Salmo salar
6850 Homo sapiens
20963 Mus musculus
25155 Rattus norvegicus
484196 Canis lupus familiaris
100125540 Sus scrofa
515515 Bos taurus
427272 Gallus gallus
100716985 Cavia porcellus
100345556 Oryctolagus cuniculus
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