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Overall novel mutations in SYK gene and in silico analysis revealed that these mutations are crucial and might be responsible for altered expression of SYK.
this study shows that SYK increased MUC5AC expression via ERK2 (show MAPK1 Proteins) and p38 MAPK (show MAPK14 Proteins) signaling pathways in airway epithelial cells
SYK, LYN (show LYN Proteins) and PTPN6 (show PTPN6 Proteins) were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients.
Syk inhibitor suppressed the phosphorylation of band 3 (show SLC4A1 Proteins) also preventing serine phosphorylation changes and hemolysis.
SYK expression was down-regulated in laryngeal squamous cell carcinoma, which was closely correlated with cancer growth and lymph node metastasis. SYK up-regulation was able to inhibit the invasion and metastasis of LSCC.
TNF (show TNF Proteins) activates Mule (show HUWE1 Proteins) by inducing the dissociation of Mule (show HUWE1 Proteins) from its inhibitor ARF. Inhibition of Mule (show HUWE1 Proteins) phosphorylation by silencing Syk prevents this, thereby inhibiting Mule (show HUWE1 Proteins) E3 ligase activity and TNF (show TNF Proteins)-induced JNK (show MAPK8 Proteins) activation and cell death.
Study establishes P-SYK as a critical biomarker in AML (show RUNX1 Proteins) that identifies tumors sensitive to SYK inhibition, identifies an at-risk patient population, and allows for the monitoring of target inhibition during treatment.
LMPs are important pro-apoptotic regulators for Rb cells through reduction of SYK expression.
Data suggest that immune complexes (ICs (show DNAI1 Proteins)) of FCGR3A (show CD16 Proteins)-SYK play critical role in activation of CD4 (show CD4 Proteins)+ T-cells and thus in modulation of adaptive immunity; such ICs (show DNAI1 Proteins) are present in blood from patients with systemic lupus erythematosus.
Syk activation is prominent in infiltrating myeloid cells in human rapidly progressive glomerulonephritis
Dectin-1 (show CLEC7A Proteins) and Dectin-2 (show CLEC6A Proteins) seem not to play a major role in Borrelia recognition or Borrelia-induced inflammation. However, Syk seems to be involved in Borrelia-induced cytokine production
TNF (show TNF Proteins) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF Proteins)-induced JNK (show MAPK8 Proteins) activation and cell death.
The effects of OXSI-2 identified in this study provide context for the role of Syk in inflammasome signaling and demonstrate its importance in oxidative signaling upstream of inflammasome activation and downstream of ion flux.
Mincle (show CLEC4E Proteins) Activation and the Syk/Card9 (show CARD9 Proteins) Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye
Syk deletion in myeloid cells is protective in mouse nephrotoxic serum nephritis.
Src (show SRC Proteins)/Syk-dependent signalling stabilises platelet adhesion to podoplanin (show PDPN Proteins)
These results provide new insights into the mechanisms by which SYK regulates MHC-II expression via autophagy in macrophages.
Syk mediates airway contractility in the normal and allergic airways, independent of its role and function in leukocytes, and supports a paracrine role for airway epithelial Syk in modulating airway smooth muscle activity.
Syk expression by DCs is necessary for IL-23p19 (show IL23A Proteins) production in response to C. albicans
The Syk inhibitor fostamatinib prevented bleomycin-induced fibrosis and inflammation in the skin and in the lung. The anti-fibrotic effect of fostamatinib is linked to reduced Syk phosphorylation and TGF-beta (show TGFB1 Proteins) expression.
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase