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Rat (Rattus) CNR1 ELISA Kit for Sandwich ELISA - ABIN433277
Wang, Zheng, Kulkarni, Wang, Garg, Prather, Hauer-Jensen: Palmitoylethanolamide Regulates Development of Intestinal Radiation Injury in a Mast Cell-Dependent Manner. in Digestive diseases and sciences 2014
Anandamide, through CB1 and TRPV1 (show TRPV1 ELISA Kits) activation, is involved in sperm release from the oviductal reservoir.
genetic or chemical inhibition of cannabinoid receptor (Cnr (show PCDHA1 ELISA Kits)) activity disrupts liver development and metabolic function in zebrafish.
CB1 function is required in the early embryo for axonal growth and fasciculation.
propose here a possible unifying theory of CB1 receptor functions.
Patients with schizophrenia showed increased CB1A expression in cells of the innate immune system and simpler correlation network between cytokines and CBRs expression when compared with controls.
our systematic review on potential associations of CNR1 polymorphisms with schizophrenia and its subphenotypes revealed conflicting data, with results tending towards a negative association.
Our study disclosed an increased risk of CVS among individuals with AG and GG genotypes of CNR1 rs806380 ( P <0.01), whereas the CC genotype of CNR1 rs806368 was associated with a decreased risk of CVS ( P <0.05). In addition CT and CC genotypes of CNR1 rs806368 were associated with a family history of migraines.
U46619 and ANG II (show AGT ELISA Kits) may stimulate rapid endothelial release of endocannabinoids (mainly 2-arachidonoylglycerol), leading to CB1 receptor-dependent and/or CB1 receptor-independent vasorelaxation, which in the negative feedback mechanism reduces later agonist-induced vasoconstriction.
Data suggest that signaling via endocannabinoids and CNR1/CNR2 plays central role in food intake; the endocannabinoid system regulates bidirectional communication (in the context of energy intake and storage) between the brain and peripheral tissues (adipose tissue, liver, gastrointestinal tract, endocrine pancreas, and skeletal muscle). [REVIEW]
Selective estrogen receptor (ER (show ESR1 ELISA Kits)) modulator (SERM) isomers exhibit distinct affinity and selectivity for cannabinoid subtype 1 and 2 receptors (CB1R and CB2Rs).
We investigated the relationship between variation in the CNR1, CNR2 (show CNR2 ELISA Kits), and FAAH (show FAAH ELISA Kits) genes and change in primary anxiety disorder severity. Five SNPs were nominally associated with a poorer treatment response (rs806365 [CNR1]; rs2501431 [CNR2 (show CNR2 ELISA Kits)]; rs2070956 [CNR2 (show CNR2 ELISA Kits)]; rs7769940 [CNR1]; rs2209172 [FAAH (show FAAH ELISA Kits)]) and one with a more favorable response (rs6928813 [CNR1]).
our results support the notion that palmitoylation of cysteine 415 modulates the conformational state of helix 8 and influences the interactions of CB1 receptor with cholesterol and caveolin 1 (show CAV1 ELISA Kits), suggesting that the palmitoyl chain may serve as a functional interface for CB1 receptor localization and function.
we investigated whether the effect of the CB1 receptor coding CNR1 gene on migraine and its symptoms is conditional on life stress. We covered the CNR1 gene with 11 SNPs. None of the SNPs showed main genetic effects on possible migraine or its symptoms. 5 SNPs showed nominally significant interaction with recent negative life events on headache with nausea
Salicylate-induced tinnitus may be associated with increased mRNA expression of the DR1A gene - but with decreased mRNA expression of the CR1 (show TDGF1 ELISA Kits) gene - in the cochlea and in many tinnitus-related brain areas.
analysis of the composition and differences of CB1 protein complexes in glutamatergic neurons and in GABAergic interneurons in hippocampal mouse tissue by proteomics
Identification of mouse CB1 receptor splice variants may help to explain differences found between human and mouse endocannabinoid systems and improve the understanding of CB1 receptor signaling and trafficking in different species
our results reveal that ERRgamma (show ESRRG ELISA Kits), induced via activation of the hepatic CB1 receptor, is a regulator of hepatic FGF21 (show FGF21 ELISA Kits) gene expression and secretion.
Morphine-induced conditioned place preference (CPP) elevated Cannabinoid CB1 receptor (CB1R) expression both in the nucleus accumbens and hippocampus. AM251 attenuated morphine-induced CPP and CB1R expression in the NAc (show NLRP1 ELISA Kits) and Hippocampus. CB1R mediated downstream ERK (show EPHB2 ELISA Kits)-CREB (show CREB1 ELISA Kits)-BDNF (show BDNF ELISA Kits) signaling is implicated in morphine reward.
In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1 (show GALR1 ELISA Kits), and the CB1 receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 (show GSDMD ELISA Kits) muscarinic receptor (show CHRM5 ELISA Kits) subtypes was also analyzed in brain areas involved in anxiety and cognition.
A bidirectional link was found between the CB1 receptor and microRNA let-7d involved in the regulation of cannabinoid signaling.
Study investigated the impact of the CB1 receptor ligands on the symptoms typical for schizophrenia. Antipsychotic-like effects induced by CB1 receptor antagonist, obtained in our research, confirm the potential effect of CB1 receptor blockade and could have important therapeutic implications on clinical settings, in the future.
CB1 activation enhances protein synthesis via the mTOR (show FRAP1 ELISA Kits) pathway, resulting in long-term depression of inhibitory transmission in GABA-ergic presynaptic interneuron axons.
Decreased expression of CB1 receptor was found in the cingulate cortex of animals exposed to chronic unpredictable stress.
The endocannabinoid system in renal cells: regulation of sodium transport by CB1 receptors through distinct cell signaling pathways
A novel mechanism has been identified underlying a CB1R-mediated increase in retinal ganglion cell intrinsic excitability acting through AMPK (show PRKAA2 ELISA Kits)-dependent inhibition of NKCC1 (show SLC12A2 ELISA Kits) activity.
CB1 functionality increased with development at both central and peripheral level.
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
cannabinoid receptor 1 (brain)
, cannabinoid receptor (brain)
, cannabinoid receptor 1
, cannabinoid receptor 1-like
, central cannabinoid receptor
, brain-type cannabinoid receptor
, striatal cannabinoid receptor type 1 protein
, cannabinoid 1 receptor
, CB1 cannabinoid receptor
, cannabinoid receptor CB-1
, cannabinoid receptor 1/CB1