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HDAC4 (show HDAC5 Proteins)-mediated SUMOylation of the corepressor DACH1 is decreased, which protects DACH1 from proteasomal degradation
The results of this study suggested the involvement of the mouse Dach1 gene in adult neurogenesis; cells expressing this gene exhibit the properties of adult NSCs or neuroblasts and respond to MCAo by enhanced neurogenesis.
find that in cells growing in IGF-1 (show IGF1 Proteins) (and unresponsive to EGF (show EGF Proteins)), DACH1 is devoid of tumor suppressor activity
The mouse dachshund gene is related to the Ski (show SKI Proteins) proto-oncogene (show RAB1A Proteins) and is expressed in eye and limb.
In the mouse, Dach1 expression in the developing ear also overlaps with the expression of Eya1 (show EYA1 Proteins) (an eya homologue)
Dach1 is a target gene of FGF signaling during limb skeletal development, and Dach1 may function as an intermediary in the FGF signaling pathway regulating cell proliferation or differentiation
Dach1 is critical for postnatal survival of mice
The phosphatase function of Eya switches the function of Six1 (show SIX1 Proteins)-Dach from repression to activation, causing transcriptional activation through recruitment of co-activators
The Pax (show PXN Proteins)-Eya-Six-Dach network is at best only partly conserved during lens and nasal placode development.
DACH1 repressed cyclin D1 (show CCND1 Proteins) through a novel mechanism via a c-Jun (show JUN Proteins) DNA-binding partner, requiring the DACH1 alpha-helical DS domain which recruits corepressors to the local chromatin.
Knockdown of DACH1 expression can remarkably enhance the cell apoptosis, restrain the proliferation, migration and invasion of Capan-1 cells.
DACH1 expression regulates the pancreatic cancer cell apoptosis.
Low DACH1 expression is associated with invasion of lung adenocarcinoma.
This study concludes that MiR (show MLXIP Proteins)-217 is the upstream regulator of PGC-1alpha in breast cancer regulation in vitro, possibly independent of DACH1 signaling pathway.
Kaplan-Mier analysis of human NSCLC samples demonstrated that high DACH1 mRNA levels predicted favorable prognosis for relapse-free and overall survival. In agreement, high CXCL5 (show CXCL5 Proteins) expression predicted a worse prognosis for survival.
DACH1 expression was reduced in hepatocellular carcinoma even at early stage and associated with tumor progression. Overexpression inhibited HCC (show FAM126A Proteins) cell growth and migration by inactivating the Wnt (show WNT2 Proteins) pathway via GSK3beta phosphorylation to suppress beta-catenin (show CTNNB1 Proteins).
In breast cancer, some GATA3 (show GATA3 Proteins) effects shift from tumor suppressing to tumor promoting during tumorigenesis, with deregulation of three genes, BCL2 (show BCL2 Proteins), DACH1, THSD4 (show THSD4 Proteins), representing major GATA3 (show GATA3 Proteins)-controlled processes in cancer progression.
Results indicated that DACH1 was a novel molecular marker of RCC (show XRCC1 Proteins) and it attributed to the malignant behavior of renal cancer cells.
Data indicate that dachshund family transcription factor 1 (show HNF1A Proteins) (DACH1) suppresses gastric cancer cell proliferation, invasion and metastasis by inhibiting transforming growth factor beta (TGF-beta) signalling pathways both in vitro and in vivo.
results suggest that DACH1 loss of function results in increased cell growth, motility and invasiveness through TGF-beta (show TGFB1 Proteins)-mediated EMT (show ITK Proteins), and DACH1 loss of function has important therapeutic implications for targeted therapies of CRC (show CALR Proteins)
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene.
dachshund homolog 1 (Drosophila)
, dachshund homolog 1
, dachshund 1
, dachshund protein
, dachshund homolog 1-like