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anti-Mouse (Murine) CD44 Antibodies:
anti-Rat (Rattus) CD44 Antibodies:
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Mouse (Murine) Monoclonal CD44 Primary Antibody for BR, CyTox - ABIN2689261
Bendelac: Mouse NK1+ T cells. in Current opinion in immunology 1995
Show all 23 Pubmed References
Mouse (Murine) Monoclonal CD44 Primary Antibody for FACS - ABIN2689265
Brocke, Piercy, Steinman, Weissman, Veromaa: Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 21 Pubmed References
Mouse (Murine) Monoclonal CD44 Primary Antibody for BR, IHC (fro) - ABIN1176866
Hathcock, Hirano, Murakami, Hodes: CD44 expression on activated B cells. Differential capacity for CD44-dependent binding to hyaluronic acid. in Journal of immunology (Baltimore, Md. : 1950) 1994
Show all 23 Pubmed References
Human Polyclonal CD44 Primary Antibody for IHC (p), WB - ABIN3043394
Cui, Qi, Guo, Qin, Gui, Cai: Rat bone marrow derived mesenchymal progenitor cells support mouse ES cell growth and germ-like cell differentiation. in Cell biology international 2009
Show all 17 Pubmed References
Mouse (Murine) Monoclonal CD44 Primary Antibody for BR, IHC (f) - ABIN1176842
Castro, Bono, Simon, Vargas, Rosemblatt: Spleen-derived stromal cells. Adhesion molecules expression and lymphocyte adhesion to reticular cells. in European journal of cell biology 1998
Show all 15 Pubmed References
Mouse (Murine) Monoclonal CD44 Primary Antibody for BR, IHC (f) - ABIN967622
Godfrey, Kennedy, Suda, Zlotnik: A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. in Journal of immunology (Baltimore, Md. : 1950) 1993
Show all 16 Pubmed References
Mouse (Murine) Monoclonal CD44 Primary Antibody for IHC (f), IHC (fro) - ABIN2689263
Hyman, Lesley, Schulte, Trotter: Progenitor cells in the thymus: most thymus-homing progenitor cells in the adult mouse thymus bear Pgp-1 glycoprotein but not interleukin-2 receptor on their cell surface. in Cellular immunology 1986
Show all 11 Pubmed References
Human Monoclonal CD44 Primary Antibody for CyTOF, FACS - ABIN4900587
Draffin, McFarlane, Hill, Johnston, Waugh: CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells. in Cancer research 2004
Show all 11 Pubmed References
Human Monoclonal CD44 Primary Antibody for CyTOF, FACS - ABIN4900724
Dingemans, Ramkema, Pals: CD44 is exposed to the extracellular matrix at invasive sites in basal cell carcinomas. in Laboratory investigation; a journal of technical methods and pathology 2002
Show all 10 Pubmed References
Cat (Feline) Monoclonal CD44 Primary Antibody for IHC (f), ICC - ABIN2749068
Si-Tahar, Sitaraman, Shibahara, Madara: Negative regulation of epithelium-neutrophil interactions via activation of CD44. in American journal of physiology. Cell physiology 2001
Show all 8 Pubmed References
MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 isoform CD44v4-10.
study demonstrates that CD44 plays a critical role in the regulation of experimental autoimmune encephalomyelitis through alterations in the gut microbiome profile and short-chain fatty acid production
CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium.
OA/GPNMB acts through ERK (show EPHB2 Antibodies) and AKT (show AKT1 Antibodies) signaling pathways in mesenchymal stem cells via CD44
These findings support the usefulness of the conditional Cd44 allele in unraveling essential physiological and pathological functions of CD44 isoforms.
CD44 role in the atrophic epidermis
CD44(high) type II cells likely represent a type II cell subpopulation important for constitutive regulation of alveolar homeostasis.
CD44V6 is part of a positive-feedback loop with TGFbeta1 (show TGFB1 Antibodies)/TGFbetaRI signaling that acts to increase NOX4 (show NOX4 Antibodies)/ROS (show ROS1 Antibodies) production, which is required for myofibroblast differentiation, myofibroblast differentiation, myofibroblast extracellular matrix production, myofibroblast invasion, and myofibroblast contractility.
HAS2 (show HAS2 Antibodies)-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1 (show MAPK3 Antibodies)/EGR1 (show EGR1 Antibodies) signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1 (show TGFB1 Antibodies)-stimulated CD44V6/ERK (show EPHB2 Antibodies)/EGR1 (show EGR1 Antibodies) signaling.
CD44 promotes accumulation of M2 macrophages, extracellular matrix deposition, and wall thickening during arteriovenous fistula maturation.
Increased CD44s protein and posttranslational modification of CD44 with polylactosamine on macrophages from stage III could be involved in the cleaning up apoptotic granulosa cells
CD44 has a key role in oocyte maturation but not in cumulus expansion.
This study demonstrates that the CD14 (show CD14 Antibodies)-negative isolation yields an enhanced cell population SFB (show CEBPB Antibodies) that is more potent than MSCP (show SLC25A37 Antibodies) as a cell source for cartilage tissue engineering.
CD44 is expressed in the cumulus-oocyte complexes during cumulus expansion. The interaction between hyaluronan and CD44 is closely related to gap junctional communication of the cumulus-oocyte complexes during meiotic resumption.
suggest that upregulation of NG2/CSPG4 (show MCSP Antibodies) rather than changes in CD44 or Ki-67 (show MKI67 Antibodies) expression is associated with low overall survival in glioblastoma multiforme patients, supporting NG2/CSPG4 (show MCSP Antibodies) as a potential prognostic marker in glioblastoma
Suggest that CD44-positivity might be a candidate tumor stem cell marker in intrahepatic cholangiocarcinoma and a prognostic indicator.
Mechanistically, CD44v interacts with and stabilizes xCT (show SLC7A11 Antibodies) and thereby promotes the uptake of cysteine for glutathione synthesis and stimulates side-population cell enrichment.
These tumor samples express CD44 protein at low rather than high levels. There is no correlation between CLDN3 (show CLDN3 Antibodies) gene expression and protein expression in these CPTAC samples; hence, the claudin-low subtype defined by gene expression is not the same group of tumors as that defined by low expression of CLDN3 (show CLDN3 Antibodies) protein.
this study shows that genkwadaphnin promotes leukocyte migration by increasing CD44 expression via PKD1 (show PKD1 Antibodies)/NF-kappaB (show NFKB1 Antibodies) signaling pathway
High CD44 expression is associated with high grade glioma.
CNS disease was associated with enhanced expression of cytoplasmic and membranous ITGA10 and nuclear PTEN (show PTEN Antibodies) (P < 0.0005, P = 0.002, P = 0.024, respectively). sCNSL presented decreased membranous CD44 and nuclear and cytoplasmic cadherin-11 expressions (P = 0.001, P = 0.006, P = 0.048, respectively). In PCNSL lactoferrin (show LTF Antibodies) expression was upregulated (P < 0.0005).
In clinical specimens of breast cancer, authors established that the expression of CD44s and HAS2 (show HAS2 Antibodies) was positively correlated. Results establish a positive feedback mechanism that sustains PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling in tumor cells, further illuminating the nearly universal role of this pathway in cancer cell survival.
In regulation of tumour cells with high CD44 expression.
ZEB1 (show ZEB1 Antibodies)-induced epithelial-to-mesenchymal transition and associated molecular changes in ESRP1 (show ESRP1 Antibodies) and CD44 contribute to early pathogenesis and metastatic potential in established lung cancer
CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2 (show HYAL2 Antibodies).
release of the CD44 intracellular domain into the cytoplasm of cells such as chondrocytes exerts a competitive or dominant-negative effect on the function of full-length CD44.
CD44 fragmentation, consistent with a signature pattern reported for sequential metalloproteinase/gamma-secretase cleavage of CD44, is a common metabolic feature of chondrocytes that have undergone dedifferentiation in vitro
determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25 (show IL2RA Antibodies), CD44, and CD62L (show SELL Antibodies) expression on peripheral blood T-cell subsets from M. bovis-infected cattle.
detection of CD44 in the bovine oviductal epithelium
Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM (show HMMR Antibodies)-mediated signalling pathways involving Cdc2 (show CDK1 Antibodies) and gamma-adducin (show ADD3 Antibodies).
The novel finding that TSP-1 (show THBS1 Antibodies)-induced migration is dependent on the CD44 receptor links 2 pathways thought to be disparate (ie, TSP-1 (show THBS1 Antibodies) and HyA (show KDM5D Antibodies)).
An important role for the Hyaluronan-CD44 signaling pathway in reproductive function and inflammation.
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
, GP90 lymphocyte homing/adhesion receptor
, extracellular matrix receptor III
, hermes antigen
, hyaluronate receptor
, lymphocyte antigen 24
, phagocytic glycoprotein 1
, phagocytic glycoprotein I
, CD44 antigen
, Cell surface glycoprotein CD44 (hyaluronate binding protein)
, Hermes antigen
, cell surface glycoprotein CD44
, chondroitin sulfate proteoglycan 8
, hematopoietic cell E- and L-selectin ligand
, heparan sulfate proteoglycan
, homing function and Indian blood group system
, extracellular matrix receptor-III
, CD44-like protein
, lymphocyte surface antigen precursor CD44
, syndecan 4 (amphiglycan, ryudocan)