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anti-Human Decorin Antibodies:
anti-Rat (Rattus) Decorin Antibodies:
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Human Polyclonal Decorin Primary Antibody for IHC, IHC (p) - ABIN4304721
Henke, Grace, Ashley, Stewart, Riddick, Yeun, ODonnell, Anderson, Thomson: Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer. in PLoS ONE 2012
Show all 5 Pubmed References
Human Polyclonal Decorin Primary Antibody for WB - ABIN965989
Danielson, Fazzio, Cohen, Cannizzaro, Eichstetter, Iozzo: The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. in Genomics 1993
Show all 3 Pubmed References
Human Polyclonal Decorin Primary Antibody for IF (p), IHC (p) - ABIN733103
Bakker, Groma, Spijkers, de Vos, van Weert, van Veen, Everts, Arribas, VanBavel: Heterogeneity in Arterial Remodeling among Sublines of Spontaneously Hypertensive Rats. in PLoS ONE 2014
Show all 3 Pubmed References
Human Monoclonal Decorin Primary Antibody for ELISA, WB - ABIN1724878
Buraschi, Neill, Owens, Iniguez, Purkins, Vadigepalli, Evans, Schaefer, Peiper, Wang, Iozzo: Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model. in PLoS ONE 2012
Show all 2 Pubmed References
Human Monoclonal Decorin Primary Antibody for FACS, ELISA - ABIN1724881
Adam, Saller, Ströbl, Hennebold, Dissen, Ojeda, Stouffer, Berg, Berg, Mayerhofer: Decorin is a part of the ovarian extracellular matrix in primates and may act as a signaling molecule. in Human reproduction (Oxford, England) 2012
Show all 2 Pubmed References
Human Polyclonal Decorin Primary Antibody for WB - ABIN514903
Gasimli, Stansfield, Nairn, Liu, Paluh, Yang, Dordick, Moremen, Linhardt: Structural remodeling of proteoglycans upon retinoic acid-induced differentiation of NCCIT cells. in Glycoconjugate journal 2013
Show all 2 Pubmed References
Human Polyclonal Decorin Primary Antibody for IHC - ABIN965978
Nadesalingam, Bernal, Dodds, Willis, Mahoney, Day, Reid, Palaniyar: Identification and characterization of a novel interaction between pulmonary surfactant protein D and decorin. in The Journal of biological chemistry 2003
Show all 8 Pubmed References
Human Polyclonal Decorin Primary Antibody for ELISA, WB - ABIN4304717
Zafiropoulos, Nikitovic, Katonis, Tsatsakis, Karamanos, Tzanakakis: Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells. in Molecular cancer research : MCR 2008
Human Polyclonal Decorin Primary Antibody for IHC, IHC (p) - ABIN4891721
Erwin, DeSouza, Funabashi, Kawchuk, Karim, Kim, Mӓdler, Matta, Wang, Mehrkens: The biological basis of degenerative disc disease: proteomic and biomechanical analysis of the canine intervertebral disc. in Arthritis research & therapy 2015
Human Monoclonal Decorin Primary Antibody for IHC (p), ELISA - ABIN560574
Faarvang, Rørdam Preil, Nielsen, Beck, Kristensen, Rasmussen: Smoking is associated with lower amounts of arterial type I collagen and decorin. in Atherosclerosis 2016
Data suggest that PEG3 (show PEG3 Antibodies) is required for TFEB (show TFEB Antibodies) induction and nuclear translocation in a VEGFR2 (show KDR Antibodies)- and AMPK (show PRKAA1 Antibodies)-dependent manner for decorin/decorin receptor-evoked autophagy. (PEG3 (show PEG3 Antibodies) = paternally expressed 3 (show PEG3 Antibodies) protein; TFEB (show TFEB Antibodies) = transcription factor EB (show TFEB Antibodies); VEGFR2 (show KDR Antibodies) = vascular endothelial growth factor receptor-2 (show KDR Antibodies); AMPK (show PRKAA1 Antibodies) = AMP-activated protein kinase (show PRKAA2 Antibodies))
Decorin exhibits promiscuity in its ability to alter tumorigenesis via regulation of angiogenesis, autophagy, and inflammation. (Review)
Quantitative polymerase chain reaction for messenger RNA expression from tissue specimens revealed significantly higher expression of Biglycan (show BGN Antibodies) (p = 0.0008) and Lumican (show LUM Antibodies) (p = 0.01) and lower expression of Decorin (p < 0.0001) in urothelial carcinoma of bladder
decorin can alter the bioactivity of TGF-beta2 (show TGFB2 Antibodies) on human myoblast migration
A Finnish cohort of 336 subjects with diagnosed hypertension and 444 controls was analyzed. Samples were genotyped for decorin rs7308752 and rs516115 polymorphisms. The GG genotype of the decorin polymorphism rs7308752 (A>G) and the CC genotype of the rs516115 (T>C) are associated with decreased plasma resistin (show RETN Antibodies) levels. These two decorin polymorphisms appear to have biological relevance in human vascular pathophysiology.
analysis of decorin and lumican (show LUM Antibodies) expression in fibroblasts correlated with palmoplantar collagen bundle size
via gain-of-function analyses, DCN overexpression could inhibit renal cell carcinoma (show MOK Antibodies) (RCC (show XRCC1 Antibodies)) cell proliferation and metastasis in vitro and vivo. At the mechanism level, we found that an ectopic expression of DCN significantly upregulated P21 (show CDKN1A Antibodies) and E-cadherin (show CDH1 Antibodies) expression. Altogether, these results revealed that DCN is a tumor suppressor in RCC (show XRCC1 Antibodies), and it could serve as a potential therapeutic target in patients with RCC (show XRCC1 Antibodies).
Internal mammary artery tissue from active smokers contains decreased amounts of type 1 collagen and decorin.
A synthetic peptide corresponding to this decorin region dose-dependently inhibited the response to myostatin (show MSTN Antibodies) in cardiomyocytes
increased blood DCN levels could be a candidate biomarker for PE.
The inclusion of decorin proteoglycan during fibrillogenesis of type I collagen increases the modulus and tensile strength of resulting collagen gels.
These findings reveal a novel role of DCN as an antagonistic ligand for VEGFR-2 (show KDR Antibodies).
Data show that biglycan (show BGN Antibodies), collagen type I, collagen type II, decorin, and versican (show Vcan Antibodies) were significantly affected by vibration duration, frequency, and amplitude.
Results suggest that decorin contributes to the formation and stabilization of collagen fibres in the perimysium that support muscle fibres assembled with myogenesis.
decorin is a dimer in solution
decorin-induced fibroblast cytoskeletal and signalling changes result in an increased cell migration; potential role in the remodelling process
Transduced bovine decorin synthesized de novo by rat arterial smooth muscle cells increases type I collagen synthesis and enhances contraction of collagen gels.
The results indicate that CTGF (show CTGF Antibodies) suppresses the synthesis of biglycan (show BGN Antibodies) but newly induced that of decorin in the cells when the cell density is low.
a novel collagen binding domain in decorin acts cooperatively with leucine-rich repeat 4 to mask the alpha2beta1 integrin-binding site on collagen, an important sequence for the phagocytosis of collagen fibrils
analysis of decorin from different bovine tissues
Asporin (show ASPN Antibodies) deficiency changes skin glycosaminoglycan composition, and decorin and biglycan (show BGN Antibodies) content, which may explain the changes in skin mechanical properties.
Fibroblasts differentiated to adipocytes and treated with TIP39 (show TFIP11 Antibodies) also showed increased decorin and production of chondroitin sulfate. Furthermore, the skin of PTH2R (show PTH2R Antibodies)(-/-) mice showed abnormal extracellular matrix structure, decreased decorin expression, and skin hardness.
The disruption of decorin-restricted TGFbeta (show TGFB1 Antibodies) signalling leads to higher stiffness of articular cartilage matrix, rendering joints more resistant to osteoarthritis.
We could show that ablation of either candidate enhanced adipogenesis in visceral preadipocytes, while treatment of primary cultures with recombinant Sparcl1 and Dcn blocked adipogenesis in a dose dependent manner. In conclusion, our data suggests that the differences in adipogenesis between depots might be due to paracrine and autocrine feedback mechanisms which could in turn contribute to metabolic homeostasis
Systemic delivery of an oncolytic adenovirus expressing decorin for the treatment of breast cancer bone metastases reduced tumor burden and inhibited bone destruction.
Decorin is an autophagy-inducible proteoglycan (show Vcan Antibodies) and is required for proper in vivo autophagy.
Importance of biglycan (show BGN Antibodies) and decorin as targets for the manipulation of fetal membrane extracellular matrix stability in the context of inflammation.
The results suggest that decorin plays a dual role in AAA (show AAAS Antibodies). Adventitial decorin in normal aorta may protect against the development of AAA (show AAAS Antibodies)
Development of congenital stromal dystrophy is dependent on export and extracellular deposition of truncated decorin.
LDL electrostatic interactions with decorin and biglycan (show BGN Antibodies) in the aortic valve leaflets and vascular wall is a major source of LDL retention.
The expression of the DCN gene increased from gestational day 26 to 90 in both Yorkshire and Meishan pig placenta.
Decorin has a critical role during early embryogenesis
Data indicate that decorin is involved in folliculogenesis/oogenesis, ovulation, and luteal phase support.
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome.
, bone proteoglycan II
, decorin proteoglycan
, dermatan sulphate proteoglycans II
, proteoglycan core protein
, small leucine-rich protein 1B
, dermatan sulfate proteoglycan-II (decorin)
, dermatan sulfate proteoglycan II
, decorin isoform a preproprotein