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Thus, GPC6 and TMEM132D may serve as predictors of CD8 (show CD8A Proteins)+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis.
GPC6 promotes invasive migration by inhibition of canonical beta-catenin (show CTNNB1 Proteins) and Wnt (show WNT2 Proteins) signalling, and up-regulation of non-canonical Wnt5A (show WNT5A Proteins) signalling leading to the activation of JNK (show MAPK8 Proteins) and p38 MAPK (show MAPK14 Proteins).
a reduction in GPC6 mRNA in retinoblastoma is associated with the non-random allelic loss at 13q31 that could contribute to RB development.
Mutations in the heparan-sulfate proteoglycan glypican 6 impair endochondral ossification and cause recessive omodysplasia
Adult female Gpc6-/- mice were compared with wild-type control mice of identical C57BL/6 background. Consistent with the phenotype of omodysplasia 1, Gpc6-/-mice had femurs and vertebrae that were shorter than those of wild-type mice. They also had increased femoral bone mineral content and increased cortical thickness.
GPC6 stimulates Hh signaling by binding to Hh and Ptc1 (show PTCH1 Proteins) at the cilium and increasing the interaction of the receptor and ligand to promote the growth of developing long bones.
data identify glypicans as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate (show GRIN1 Proteins) receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.
, glypican proteoglycan 6