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Browse our Heparanase Proteins (HPSE)

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Heparanase Proteins (HPSE)
On are 29 Heparanase (HPSE) Proteins from 8 different suppliers available. Additionally we are shipping Heparanase Antibodies (200) and Heparanase Kits (42) and many more products for this protein. A total of 276 Heparanase products are currently listed.
Hep, Hpa, HPA1, Hpr1, HPSE, HPSE1, HSE1, im:7144134
list all proteins Gene Name GeneID UniProt
HPSE 10855 Q9Y251
HPSE 15442 Q6YGZ1
HPSE 64537 Q71RP1

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Heparanase Proteins (HPSE) by Origin

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More Proteins for Heparanase Interaction Partners

Human Heparanase (HPSE) interaction partners

  1. The most common HPA genotypes among Saudis were HPA-1 a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA-4 a + b- (99%), HPA-5 (show ITGA2 Proteins) a + b- (76.5%), HPA-6 a + b- (100%) and HPA-15 a + b + (50%). The prevalent allele among the HPA systems was (a), except in the HPA-15 system where the (b) allele was found in 52% of the subjects.

  2. heparanase activity is increased without changes in superoxide dismutase (show SOD1 Proteins) activity in the granulocytes from patients with lupus nephritis and membranous nephropathy

  3. Heparanase up-regulated the expression of the blood coagulation initiator-tissue factor (show F3 Proteins) (TF) and interacted with the tissue factor pathway inhibitor (TFPI (show TFPI Proteins)) on the cell surface membrane of endothelial and tumor cells, leading to dissociation of TFPI (show TFPI Proteins) and resulting in increased cell surface coagulation activity. [review]

  4. Heparanase procoagulant activity predicts post-surgery necrosis.

  5. Suggest heparanase is a promising, novel target for overcoming myeloma resistance to therapy and that targeting heparanase has the potential to prevent relapse in myeloma and possibly other cancers.

  6. expression of BRMS1 (show BRMS1 Proteins) and/or HPA might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma

  7. in colorectal adenomas, the heparanase-1 does not participate in syndecan-1 (show SDC1 Proteins) degradation; the heparanase-2 does not stimulate syndecan-1 (show SDC1 Proteins) degradation by the action of heparanase-1, and the heparanase-2 may be involved in the modulation of the heparanase-1 activity.

  8. higher heparanase expression in gastric cancer is associated with clinicopathologic features of depth of invasion, lymph node metastasis.

  9. JAK-2 (show JAK2 Proteins) V617F mutation results in heparanase up-regulation via the erythropoietin receptor (show EPOR Proteins).

  10. Studies indicate that heparanase (HPSE) has been a potential target of medical treatment.

Mouse (Murine) Heparanase (HPSE) interaction partners

  1. Heparanase increases the inflammation in AGEs-stimulated macrophages through activating the RAGE (show AGER Proteins)-NF-kappaB (show NFKB1 Proteins) pathway. Heparanase driven inflammation from AGEs-stimulated macrophages increases the adherence of glomerular endothelial cells (GEnCs) and augments the permeability of GEnCs.

  2. heparanase contributes to allergen-induced eosinophil recruitment to the lung.

  3. Unfractionated heparin inhibits heparanase, and reverses the activation of NF-kappaB (show NFKB1 Proteins) and MAPK P38 (show MAPK1 Proteins) signaling pathways to attenuate inflammatory responses induced by sepsis. These results suggest that UFH

  4. Results show a critical role for heparanase in regulating the branching and invasive behavior of normal mammary epithelia which could be the result of its mutually reciprocal feedback with MMP-14 (show MMP14 Proteins).

  5. Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1 (show SDC1 Proteins)) and -beta-D-glucuronidase (show GUSB Proteins) heparanase (HPSE).

  6. Findings identify a dual function for HPSE in malignant melanoma with a protumorigenic extracellular activity and a tumor-suppressive nuclear action.

  7. Studies in heparanase-deficient mice established its contributions to autophagy.

  8. Heparanase is suggested to be a prognostic and diagnostic marker for oral premalignant lesions which could have a major impact on future prognosis and diagnosis of SCC (show CYP11A1 Proteins) of the oral cavity.

  9. Novel function of heparanase guides cancer-promoting action of TAM (show CCNA1 Proteins) and heparanase expression status may be predictive of treatment potential, targeting TAM (show CCNA1 Proteins)/IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins).

  10. Under diabetic conditions, latent heparanase, overexpressed by glomerular cells and posttranslationally activated by cathepsin L (show CTSL1 Proteins) of tubular origin creates chronic inflammatory conditions and fosters macrophage-mediated renal injury.

Pig (Porcine) Heparanase (HPSE) interaction partners

  1. during late gestation, the mRNA and HPSE levels were higher in Meishan placentae than Yorkshire pigs

  2. study of tissue expression profiles, polymorphisms of HPSE and HPSE2 genes and changes of their mRNA levels in porcine alveolar macrophages (PAMs) induced by PRRSV; upon stimulation in healthy piglets with PRRSV, HPSE mRNA was obviously upregulated, while HPSE2 mRNA did not induce a prominent change in PAMs

  3. our results support a critical role for heparanase in the development of vulnerable atherosclerotic plaques

  4. report molecular cloning and characterisation of heparanase mRNA in the porcine placenta throughout gestation.

Cow (Bovine) Heparanase (HPSE) interaction partners

  1. Suggest that high glucose is a potent stimulator of endothelial heparanase secretion.

  2. Lutropin (show LHB Proteins) induces a transient increase in HPSE mRNA at specific times after its addition.

Heparanase (HPSE) Protein Profile

Protein Summary

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Heparanase (HPSE)

  • heparanase (HPSE)
  • heparanase (hpse)
  • heparanase (Hpse)
  • heparanase (LOC100101601)
  • Hep protein
  • Hpa protein
  • HPA1 protein
  • Hpr1 protein
  • HPSE protein
  • HPSE1 protein
  • HSE1 protein
  • im:7144134 protein

Protein level used designations for Heparanase Proteins (HPSE)

heparanase , endo-glucoronidase , heparanase-1 , endoglycosidase heparanase , heparanase-like

100061267 Equus caballus
563020 Danio rerio
100145320 Xenopus (Silurana) tropicalis
461206 Pan troglodytes
707583 Macaca mulatta
10855 Homo sapiens
15442 Mus musculus
64537 Rattus norvegicus
100101601 Oryctolagus cuniculus
100721886 Cavia porcellus
608707 Canis lupus familiaris
100271932 Sus scrofa
281230 Bos taurus
373981 Gallus gallus
101118612 Ovis aries
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