Browse our Heparanase Proteins (HPSE)

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Heparanase Proteins (HPSE)
On are 28 Heparanase (HPSE) Proteins from 7 different suppliers available. Additionally we are shipping Heparanase Antibodies (194) and Heparanase Kits (49) and many more products for this protein. A total of 276 Heparanase products are currently listed.
Hep, Hpa, HPA1, Hpr1, HPSE, HPSE1, HSE1, im:7144134
list all proteins Gene Name GeneID UniProt
HPSE 10855 Q9Y251
HPSE 15442 Q6YGZ1
HPSE 64537 Q71RP1

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Heparanase Proteins (HPSE) by Origin

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Human Heparanase (HPSE) interaction partners

  1. miR (show MLXIP Proteins)-558 facilitates the progression of gastric cancer through directly targeting the HPSE promoter to attenuate Smad4 (show SMAD4 Proteins)-mediated repression of HPSE expression.

  2. High HPSE expression is associated with breast carcinoma.

  3. data suggest that heparanase plays a critical role in NK cell invasion into tumors and thereby tumor progression and metastases.

  4. The heparanase/syndecan1 (show SDC1 Proteins) axis in gallbladder carcinoma cells plays an important role in the invasion and metastasis, thus providing a new therapeutic target.

  5. Results show that HPSE is upregulated in human glioma and seems to confer a growth advantage on glioma cells.

  6. under physiological pH and low levels of tissue factor (show F3 Proteins), heparanase may exert a non-enzymatic function interacting and activating the inhibitory function of antithrombin (show SERPINC1 Proteins).

  7. Heparanase has emerged as a major regulator of cancer by degrading heparan sulfate thereby influencing multiple signaling pathways that control gene expression, syndecan (show SDC1 Proteins) shedding and cell behavior. (Review)

  8. The most common HPA genotypes among Saudis were HPA-1 a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA-4 a + b- (99%), HPA-5 (show ITGA2 Proteins) a + b- (76.5%), HPA-6 a + b- (100%) and HPA-15 a + b + (50%). The prevalent allele among the HPA systems was (a), except in the HPA-15 system where the (b) allele was found in 52% of the subjects.

  9. heparanase activity is increased without changes in superoxide dismutase (show SOD1 Proteins) activity in the granulocytes from patients with lupus nephritis and membranous nephropathy

  10. Heparanase up-regulated the expression of the blood coagulation initiator-tissue factor (show F3 Proteins) (TF) and interacted with the tissue factor pathway inhibitor (TFPI (show TFPI Proteins)) on the cell surface membrane of endothelial and tumor cells, leading to dissociation of TFPI (show TFPI Proteins) and resulting in increased cell surface coagulation activity. [review]

Mouse (Murine) Heparanase (HPSE) interaction partners

  1. eNOS (show NOS3 Proteins) prevents heparanase induction and the development of proteinuria

  2. Data show that heparanase-1 (HPA-1) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (show SDC1 Proteins)) facilitated the release of vascular endothelial growth factor C (VEGF-C (show VEGFC Proteins)) from SDC-1 (show SDC1 Proteins)/VEGF-C (show VEGFC Proteins) complex into the medium of hepatocarcinoma cell.

  3. the activation of intestinal heparanase contributes to intestinal injury during early sepsis by facilitating the destruction of mucosal epithelial glycocalyx and promoting inflammatory responses.

  4. Heparanase increases the inflammation in AGEs-stimulated macrophages through activating the RAGE (show AGER Proteins)-NF-kappaB (show NFKB1 Proteins) pathway. Heparanase driven inflammation from AGEs-stimulated macrophages increases the adherence of glomerular endothelial cells (GEnCs) and augments the permeability of GEnCs.

  5. heparanase contributes to allergen-induced eosinophil recruitment to the lung.

  6. Unfractionated heparin inhibits heparanase, and reverses the activation of NF-kappaB (show NFKB1 Proteins) and MAPK P38 (show MAPK1 Proteins) signaling pathways to attenuate inflammatory responses induced by sepsis. These results suggest that UFH

  7. Results show a critical role for heparanase in regulating the branching and invasive behavior of normal mammary epithelia which could be the result of its mutually reciprocal feedback with MMP-14 (show MMP14 Proteins).

  8. Data suggest a potential mechanism of diabetic enteropathy, which is depending remarkably on syndecan-1 (Sdc1 (show SDC1 Proteins)) and -beta-D-glucuronidase (show GUSB Proteins) heparanase (HPSE).

  9. Findings identify a dual function for HPSE in malignant melanoma with a protumorigenic extracellular activity and a tumor-suppressive nuclear action.

  10. Studies in heparanase-deficient mice established its contributions to autophagy.

Pig (Porcine) Heparanase (HPSE) interaction partners

  1. These data suggest that porcine reproductive and respiratory syndrome virus activates NF-kappaB (show NFKB1 Proteins) and cathepsin L to upregulate and process heparanase, and then the active heparanase cleaves heparan sulfate, resulting in viral release.

  2. during late gestation, the mRNA and HPSE levels were higher in Meishan placentae than Yorkshire pigs

  3. study of tissue expression profiles, polymorphisms of HPSE and HPSE2 genes and changes of their mRNA levels in porcine alveolar macrophages (PAMs) induced by PRRSV; upon stimulation in healthy piglets with PRRSV, HPSE mRNA was obviously upregulated, while HPSE2 mRNA did not induce a prominent change in PAMs

  4. our results support a critical role for heparanase in the development of vulnerable atherosclerotic plaques

  5. report molecular cloning and characterisation of heparanase mRNA in the porcine placenta throughout gestation.

Cow (Bovine) Heparanase (HPSE) interaction partners

  1. Suggest that high glucose is a potent stimulator of endothelial heparanase secretion.

  2. Lutropin (show LHB Proteins) induces a transient increase in HPSE mRNA at specific times after its addition.

Heparanase (HPSE) Protein Profile

Protein Summary

Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Heparanase (HPSE)

  • heparanase (HPSE)
  • heparanase (hpse)
  • heparanase (Hpse)
  • heparanase (LOC100101601)
  • Hep protein
  • Hpa protein
  • HPA1 protein
  • Hpr1 protein
  • HPSE protein
  • HPSE1 protein
  • HSE1 protein
  • im:7144134 protein

Protein level used designations for Heparanase Proteins (HPSE)

heparanase , endo-glucoronidase , heparanase-1 , endoglycosidase heparanase , heparanase-like

100061267 Equus caballus
563020 Danio rerio
100145320 Xenopus (Silurana) tropicalis
461206 Pan troglodytes
707583 Macaca mulatta
10855 Homo sapiens
15442 Mus musculus
64537 Rattus norvegicus
100101601 Oryctolagus cuniculus
100721886 Cavia porcellus
608707 Canis lupus familiaris
100271932 Sus scrofa
281230 Bos taurus
373981 Gallus gallus
101118612 Ovis aries
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