Browse our UGDH Proteins (UGDH)

Full name:
UDP-Glucose 6-Dehydrogenase Proteins (UGDH)
On are 18 UDP-Glucose 6-Dehydrogenase (UGDH) Proteins from 8 different suppliers available. Additionally we are shipping UGDH Antibodies (75) and UGDH Kits (5) and many more products for this protein. A total of 104 UGDH products are currently listed.
8310, AGR_L_1413, BA5434, BG01214, CG10072, Dmel\\CG10072, GDH, ik:tdsubc_2a8, kiwi, l(3)05007, l(3)08310, l(3)65CEd, l(3)10503, l(3)SG9, SCBAC19G2.07, Sgl, ska, sl, tdsubc_2a8, udg, UDP-GlcDH, udpg, Udpgdh, UGD, ugdh, ugdha, ugdhb, XIII, xugdh, xx:tdsubc_2a8
list all proteins Gene Name GeneID UniProt
UGDH 7358 O60701
UGDH 83472 O70199
Mouse UGDH UGDH 22235 O70475

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UGDH Proteins (UGDH) by Origin

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Top referenced UGDH Proteins

  1. Human UGDH Protein expressed in Escherichia coli (E. coli) - ABIN667140 : Bontemps, Vuillermoz, Antonicelli, Perreau, Danan, Maquart, Wegrowski: Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for 667140

More Proteins for UGDH Interaction Partners

Xenopus laevis UDP-Glucose 6-Dehydrogenase (UGDH) interaction partners

  1. UDP-glucose dehydrogenase has a role in hyaluronan synthesis

Human UDP-Glucose 6-Dehydrogenase (UGDH) interaction partners

  1. Data indicate that the A136M substitution in UDP-glucose dehydrogenase (hUGDH) stabilizes the hexamer.

  2. study has identified several new proteins like RHOC (show RHOC Proteins), DLG5 (show DLG5 Proteins), UGDH, TMOD3 (show TMOD3 Proteins) in addition to known chemoresistance associated proteins in non-small cell lung carcinoma.

  3. UGDH protein level in osteoarthritis cartilage was much lower than in control cartilage.

  4. UGDH displays hysteresis because of a slow isomerization from an inactive state (E*) to an active state (E). We show that the structure of E* constrains UGDH in a conformation that favors feedback inhibition at physiological pH.

  5. Kinetic analysis of wild-type UGDH and hexamer T325A showed that upon increasing enzyme concentration, which favors the hexameric species, activity was decreased and exhibited cooperativity. Cooperative kinetics was not observed in obligate dimer T325D.

  6. Mammalian UGDH displays hysteresis (observed as a lag (show STMN1 Proteins) in progress curves), indicating that the enzyme undergoes a slow transition from an inactive to an active state. Human UGDH is sensitive to product inhibition during the lag (show STMN1 Proteins).

  7. both missense mutations significantly reducing the ability of UGDH to provide precursors for cardiac cushion formation, which is essential to subsequent valve formation.

  8. Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates.

  9. An alternate crystal structure of human UGDH (hUGDH) in complex with UDP-glucose at 2.8 A resolution, is reported.

  10. A structurally detailed model of UDP-alpha-D-glucose 6-dehydrogenase (UGDH) demonstrates hinge-bending motion that represents allosteric feedback inhibition and substrate-product exchange during the catalytic cycle.

Mouse (Murine) UDP-Glucose 6-Dehydrogenase (UGDH) interaction partners

  1. Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 (show NFE2L2 Proteins) regulation: cytochrome CYP2A5, GSTM3 (show glutathione S-transferase mu 3 (brain) Proteins), GSTM1 (show GSTM1 Proteins), ENTPD5 (show ENTPD5 Proteins),UDPGDH, and EPHX1 (show EPHX1 Proteins).

UGDH Protein Profile

Protein Summary

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with UGDH

  • sugarless (sgl)
  • UDP-glucose dehydrogenase (ugdh)
  • UDP-glucose 6-dehydrogenase (ugdh-b)
  • UDP-glucose 6-dehydrogenase (UGDH)
  • UDP-glucose 6-dehydrogenase (ugdh)
  • UDP-glucose 6-dehydrogenase (ugdh-a)
  • UDP-glucose 6-dehydrogenase (hasB)
  • UDP-glucose 6-dehydrogenase (ugdH)
  • UDP-glucose 6-dehydrogenase (ugd)
  • UDP-glucose 6-dehydrogenase (SCO3052)
  • UDP-glucose 6-dehydrogenase (CNL06460)
  • UDP-glucose 6-dehydrogenase (Ugdh)
  • UDP-glucose dehydrogenase (Ugdh)
  • 8310 protein
  • AGR_L_1413 protein
  • BA5434 protein
  • BG01214 protein
  • CG10072 protein
  • Dmel\\CG10072 protein
  • GDH protein
  • ik:tdsubc_2a8 protein
  • kiwi protein
  • l(3)05007 protein
  • l(3)08310 protein
  • l(3)65CEd protein
  • l(3)10503 protein
  • l(3)SG9 protein
  • SCBAC19G2.07 protein
  • Sgl protein
  • ska protein
  • sl protein
  • tdsubc_2a8 protein
  • udg protein
  • UDP-GlcDH protein
  • udpg protein
  • Udpgdh protein
  • UGD protein
  • ugdh protein
  • ugdha protein
  • ugdhb protein
  • XIII protein
  • xugdh protein
  • xx:tdsubc_2a8 protein

Protein level used designations for UGDH

CG10072-PA , UDP-glucose 6-dehydrogenase , UDP-glucose dehydrogenase , distal W5.4 group XIII , kiwi , lethal(3)SG9 , sgl-PA , suppenkasper , jek , jekyll , UDP-glucose dehydrogenase b , UDP-glucose dehydrogenase a , UDP-Glc dehydrogenase , uridine diphospho-glucose dehydrogenase , UDP-GlcDH , UDP-glucose dehydrogeanse , UDPGDH

38760 Drosophila melanogaster
116991 Danio rerio
379152 Xenopus laevis
471171 Pan troglodytes
541452 Xenopus (Silurana) tropicalis
734199 Xenopus laevis
901876 Streptococcus pyogenes M1 GAS
994258 Streptococcus pyogenes MGAS8232
1048955 Bradyrhizobium diazoefficiens USDA 110
1050618 Bradyrhizobium diazoefficiens USDA 110
1085034 Bacillus anthracis str. Ames
1098485 Streptomyces coelicolor A3(2)
1136023 Agrobacterium fabrum str. C58
1172269 Shewanella oneidensis MR-1
1208739 Coxiella burnetii RSA 493
1248624 Salmonella enterica subsp. enterica serovar Typhi str. CT18
1796512 Rhodopirellula baltica SH 1
2686288 Geobacter sulfurreducens PCA
3104468 Methylococcus capsulatus str. Bath
3176517 Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
3255012 Cryptococcus neoformans var. neoformans JEC21
7386467 Agrobacterium vitis S4
10978101 Zobellia galactanivorans
100016058 Monodelphis domestica
100055067 Equus caballus
100174620 Pongo abelii
100355018 Oryctolagus cuniculus
7358 Homo sapiens
83472 Rattus norvegicus
281564 Bos taurus
479107 Canis lupus familiaris
100627727 Sus scrofa
422792 Gallus gallus
22235 Mus musculus
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