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Human IGFBP7 ELISA Kit for Sandwich ELISA - ABIN415270
Watanabe, Takiyama, Honjyo, Makino, Fujita, Tateno, Haneda: Role of IGFBP7 in Diabetic Nephropathy: TGF-β1 Induces IGFBP7 via Smad2/4 in Human Renal Proximal Tubular Epithelial Cells. in PLoS ONE 2016
High IGFBP7 expression is associated with acute kidney injury.
NEAT1-associated paraspeckle proteins P54nrb (show NONO ELISA Kits) and PSF have been reported as positive regulators of c-Myc (show MYC ELISA Kits) translation through interaction with c-Myc (show MYC ELISA Kits) IRES
Urine [TIMP-2 (show TIMP2 ELISA Kits)]*[IGFBP7] is a promising candidate for early detection of AKI, especially in ruling-out AKI
Meta-analysis indicated that urinary [TIMP-2 (show TIMP2 ELISA Kits)].[IGFBP7] may be a reliable biomarker for the early detection of acute kidney injury in adults.
TIMP-2 (show TIMP2 ELISA Kits) is both expressed and secreted preferentially by cells of distal tubule origin, while IGFBP7 is equally expressed across tubule cell types yet preferentially secreted by cells of proximal tubule origin. In human kidney tissue, strong staining of IGFBP7 was seen in the luminal brush-border region of a subset of proximal tubule cells, and TIMP-2 (show TIMP2 ELISA Kits) stained intracellularly in distal tubules.
loss of IGFBP7 and upregulation of IGF1 (show IGF1 ELISA Kits) activates the FGF4 (show FGF4 ELISA Kits)-FGFR1 (show FGFR1 ELISA Kits)-ETS2 (show ETS2 ELISA Kits) pathway in Tumor-associated endothelial cells (TECs) and converts naive tumor cells to chemoresistant tumor stem-like cells (TSCs), thereby facilitating their invasiveness and progression.
Data report that IGFBP7 is a novel target gene of ADAR2 (show ADARB1 ELISA Kits) in esophageal squamous cell carcinoma where its RNA is edited and protein stabilized by ADAR2 (show ADARB1 ELISA Kits).
quantitative urine test is available to assess the risk of developing AKI by measuring the concentrations of two protein biomarkers, TIMP-2 (show TIMP2 ELISA Kits) and IGFBP-7
Insulin-like growth factor binding protein 7 (IGFBP7) was proven to be associated with metastatic clinicopathological features and high lymphatic vascular density
analysis of how A-to-I RNA editing of the IGFBP7 transcript increases during aging in porcine brain tissues
Study shows that IGFBP7 contributes significantly to mesenchymal stromal cells (MSC (show MSC ELISA Kits))-mediated immune modulation, as is shown by decreasing ability of IGFBP7 knockdown in MSCs to restore proliferation and cytokine production in T-cells.
data suggest that IGFBP-7 was up regulated during EAE and inhibit the transition from OPCs to mature OLs, implying its use as a potential therapeutic target for the treatment of inflammatory demyelinating diseases
Our data suggest that loss of Igfbp7 induces precocious involution possibly through diminished cell survival signals.
Angiomodulin is necessary for cardiac commitment of embryonic stem cells (ESCs (show NR2E3 ELISA Kits)) and its regulation depends on TAp63 isoform.
results show that Smarcb1 (show SMARCB1 ELISA Kits) is required for transcriptional activation of Igfbp7 and show that re-introduction of Igfbp7 alone can hinder tumor development; results define a novel mechanism for Smarcb1 (show SMARCB1 ELISA Kits)-mediated tumorigenesis
a model whereby IGFBP7 binds to unoccupied IGF1R (show IGF1R ELISA Kits) and suppresses downstream signaling, thereby inhibiting protein synthesis, cell growth, and survival.
IGFBP7 has a novel role in mouse uterus: it is regulating uterine receptivity through Th1 (show HAND1 ELISA Kits)/Th2 lymphocyte balance and decidualization.
fear extinction-induced IGF2/IGFBP7 signalling promotes the survival of 17-19-day-old newborn hippocampal neurons
Results demonstrate that the vascular-specific marker angiomodulin (AGM) modulates vascular remodeling in part by temporizing the proangiogenic effects of VEGF-A (show VEGFA ELISA Kits).
study showed that IGFBP-rP1 (IGFBP7) was expressed in dysregulated podocytes in a human immunodeficiency virus-associated nephropathy model and in immature podocytes in the developing kidney; conclude that IGFBP-rP1 may be a product of injured podocytes
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307).
insulin-like growth factor-binding protein 7
, IGF-binding protein 7
, PGI2-stimulating factor
, prostacyclin-stimulating factor
, tumor-derived adhesion factor