Browse our DISP1 Proteins (DISP1)

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Dispatched Homolog 1 (Drosophila) Proteins (DISP1)
On are 6 Dispatched Homolog 1 (Drosophila) (DISP1) Proteins from 4 different suppliers available. Additionally we are shipping DISP1 Antibodies (40) and DISP1 Kits (2) and many more products for this protein. A total of 53 DISP1 products are currently listed.
1190008H24Rik, con, DISP1, DispA, zgc:111866
list all proteins Gene Name GeneID UniProt
DISP1 84976 Q96F81
DISP1 68897 Q3TDN0
Rat DISP1 DISP1 289338  

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DISP1 Proteins (DISP1) by Origin

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More Proteins for DISP1 Interaction Partners

Human Dispatched Homolog 1 (Drosophila) (DISP1) interaction partners

  1. The top single-nucleotide polymorphism (SNP) was rs17162912 (P=1.76 x 10(-8)), which is near the DISP1 gene on 1q41-q42, a microdeletion region implicated in neurological development.

  2. DISP-1 is required for non-small cell lung carcinoma cells proliferation

  3. Studies indicate that DISP1 haploinsufficiency may not be solely responsible for the major features of 1q41q42 microdeletion syndrome, and other genes in the SRO likely play a role in the phenotype.

  4. report of 1st de novo DISP1 point mutation in patient with congenital diaphragmatic hernia (CDH (show CHDH Proteins)); finding with Disp1 embryonic mouse diaphragm and lung expression and previously reported 1q41q42 aberrations in CDH (show CHDH Proteins) suggests DISP1 may be CDH (show CHDH Proteins) candidate gene

  5. describe two independent families with truncating mutations in DISP1 that resemble the cardinal (show CARD8 Proteins) craniofacial and neuro-developmental features of a recently described microdeletion syndrome that includes this gene

Mouse (Murine) Dispatched Homolog 1 (Drosophila) (DISP1) interaction partners

  1. Shh (show SHH Proteins) signaling is required within the notochord to maintain Shh (show SHH Proteins) expression and to prevent notochord degeneration. Disp1, unlike Smo, is not required for this juxtacrine signaling by Shh (show SHH Proteins).

  2. Disp is required for the movement of Hh protein from its sites of synthesis in mice

  3. Disp1 has a role in sonic hedgehog (show SHH Proteins)-expressing cells for paracrine activity of the cholesterol-modified ligand

  4. Disp1 regulates growth of mammalian long bones through the control of Indian hedgehog (show IHH Proteins) distribution.

Zebrafish Dispatched Homolog 1 (Drosophila) (DISP1) interaction partners

  1. Study shows that disp1 is required for post-migratory cranial neural crest cells (CNCC) to become properly patterned within the first arch, while the gene is dispensable for CNCC condensation and patterning in more posterior arches.

  2. Disp1 activity is essential for the secretion of lipid-modified Hh proteins from midline structures.

DISP1 Protein Profile

Protein Summary

The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo.

Alternative names and synonyms associated with DISP1

  • dispatched (CpipJ_CPIJ008642)
  • dispatched homolog 1 (Drosophila) (DISP1)
  • dispatched homolog 1 (Drosophila) (Disp1)
  • dispatched homolog 1 (Drosophila) (disp1)
  • 1190008H24Rik protein
  • con protein
  • DISP1 protein
  • DispA protein
  • zgc:111866 protein

Protein level used designations for DISP1

dispatched , dispatched homolog 1 (Drosophila) , dispatched A , protein dispatched homolog 1 , mdispa , twelve-pass transmembrane protein , chameleon , dispatched 1 , helix , hlx , protein chameleon

6040881 Culex quinquefasciatus
421333 Gallus gallus
457761 Pan troglodytes
488604 Canis lupus familiaris
534637 Bos taurus
100018449 Monodelphis domestica
100548328 Meleagris gallopavo
84976 Homo sapiens
68897 Mus musculus
619201 Danio rerio
289338 Rattus norvegicus
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