Browse our GLI1 Proteins (GLI1)

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Zinc Finger Protein GLI1 Proteins (GLI1)
On are 10 Zinc Finger Protein GLI1 (GLI1) Proteins from 5 different suppliers available. Additionally we are shipping GLI1 Antibodies (193) and GLI1 Kits (10) and many more products for this protein. A total of 220 GLI1 products are currently listed.
AV235269, Gli, Gli-1, gli1.1, Zfp-5, Zfp5
list all proteins Gene Name GeneID UniProt
GLI1 2735 P08151
GLI1 140589  
GLI1 14632 P47806

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GLI1 Proteins (GLI1) by Origin

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Human Zinc Finger Protein GLI1 (GLI1) interaction partners

  1. Case Report: gastric pericytoma harboring the exceptionally rare translocation t(7;12) resulting in ACTB (show ACTB Proteins)-GLI1 gene fusion.

  2. USP21 (show USP21 Proteins) recruits and stabilises Gli1 at the centrosome.

  3. Gli1 expression was significantly correlated with T stage lymph node metastasis, and clinical stage of lung squamous cell carcinoma.

  4. Gli1 role in cell proliferation and differentiation

  5. Gli1 inhibitor GANT61 and SHH (show SHH Proteins) siRNA synergistically enhanced cytotoxicity induced by itraconazole in MCF-7 cells.

  6. Hedgehog (show SHH Proteins) pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.

  7. Our studies demonstrate an important role for smoothened and glioma-associated oncogene homology-1 in gastric cancer and suggest inhibition of hedgehog (show SHH Proteins) pathway as a novel and potent strategy to treat gastric cancer patients

  8. GANT61, which is a targeted inhibitor of Gli1 and Gli2, decreased cell viability and promoted cell apoptosis. Thus, TGF-b1 induced EMT (show ITK Proteins) in neuroblastoma (show ARHGEF16 Proteins) cells to increase their migration. Specifically, EMT (show ITK Proteins) induced by TGF-b1 in neuroblastoma (show ARHGEF16 Proteins) cells did not depend on the Smad (show SMAD1 Proteins) signaling pathway, and the transcription factor Gli participated in TGF-b1-induced EMT (show ITK Proteins) independent of Smad (show SMAD1 Proteins) signaling.

  9. Gli1 expression was detected in most ERM (show ETV5 Proteins) specimens. Patients who had DR or OCT (show Plxna2 Proteins) findings indicating chronic retinal insults showed higher Gli1 expression. Gli1 may have a role in the pathogenesis of ERM (show ETV5 Proteins) after chronic retinal insults.

  10. Overexpression of GLI1 through a recurrent MALAT1-GLI1 translocation or GLI1 up-regulation delineates a pathogenically distinct subgroup of plexiform fibromyxomas with activation of the Sonic Hedgehog (show SHH Proteins) signalling pathway.

Cow (Bovine) Zinc Finger Protein GLI1 (GLI1) interaction partners

  1. Data indicate that the expression levels of transcription factors Gli1 and Gli2 in muscle were the lowest of the 13 tissues.

Xenopus laevis Zinc Finger Protein GLI1 (GLI1) interaction partners

  1. Dzip1 (show DZIP1 Proteins)-dependent stabilization of Spop (show SPOP Proteins)/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.

  2. Zyxin (show ZYX Proteins) inhibits Shh (show SHH Proteins) signaling during the CNS patterning in Xenopus laevis through interaction with Gli1

Zebrafish Zinc Finger Protein GLI1 (GLI1) interaction partners

  1. a new mechanism of Gli transcription factor activation and implicate ARHGAP36 (show ARHGAP36 Proteins) dysregulation in the onset and/or progression of GLI-dependent cancers.

  2. We show that Kif7 interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 in Drosophila.

  3. Gli1 has a Hh-independent role in many motoneurons and V3 domain cells in embryos that lack Hh signalling, but removal of Gli1 activity does not affect more dorsal neurons.

  4. These results reveal divergent requirements for Gli1 and Gli2 in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 has minor roles as a repressor or activator of Hh targets.

  5. Gli1 regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (show SGPL1 Proteins)) factor activity.

Mouse (Murine) Zinc Finger Protein GLI1 (GLI1) interaction partners

  1. USP21 (show USP21 Proteins) recruits and stabilises Gli1 at the centrosome.

  2. High Gli1 expression is associated with leukemia.

  3. Sufu (show SUFUH Proteins) is upregulated in active Shh (show SHH Proteins) responding tissues and accompanies Gli activators translocating into and Gli repressors out of the nucleus.

  4. Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.

  5. NANOG (show NANOG Proteins) binds to GLI1 and GLI3 (show GLI3 Proteins) proteins and represses Hedgehog (show SHH Proteins)-mediated transcription.

  6. characterization of the contribution to remyelination of a subset of adult neural stem cells, identified by their expression of Gli1, a transcriptional effector of the sonic hedgehog (show SHH Proteins) pathway

  7. the three GLI factors(GLI1, GLI2, and GLI3 (show GLI3 Proteins)) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism

  8. Gli1, a known Ptch (show PTCH1 Proteins) activator, preferentially bound the mutant Ptch (show PTCH1 Proteins) locus in rhabdomyosarcoma.

  9. show that combined targeting of GLI and PI3K/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling can have a synergistic therapeutic effect in cells from a subgroup of chronic lymphocytic leukemia patients

  10. Beta-catenin (show CTNNB1 Proteins) stabilization increases its physical interaction with Gli1.

GLI1 Protein Profile

Protein Summary

This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GLI1

  • GLI family zinc finger 1 (GLI1)
  • GLI family zinc finger 1 (Gli1)
  • GLI family zinc finger 1 (gli1)
  • GLI-Kruppel family member 1 (gli1)
  • GLI-Kruppel family member GLI1 (Gli1)
  • AV235269 protein
  • Gli protein
  • Gli-1 protein
  • gli1.1 protein
  • Zfp-5 protein
  • Zfp5 protein

Protein level used designations for GLI1

glioma-associated oncogene 1 , glioma-associated oncogene homolog 1 (zinc finger protein) , oncogene GLI , zinc finger protein GLI1 , GLI-Kruppel family member GLI1 , GLI family zinc finger 1, gene 1 , zinc finger DNA binding protein Gli-1 , detour , dtr , glioma-associated oncogene homolog , zinc finger protein 5

2735 Homo sapiens
481126 Canis lupus familiaris
517588 Bos taurus
100033937 Equus caballus
140589 Rattus norvegicus
396045 Gallus gallus
398350 Xenopus laevis
352930 Danio rerio
14632 Mus musculus
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