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GLI1 may be a biomarker of poor prognosis in rhabdomyosarcoma patients, and could itself be a therapeutic target
TRIM16 (show TRIM16 Proteins) directly regulated the degradation of Gli1 protein via the ubiquitinproteasome pathway.
Results show that PCAF (show KAT2B Proteins) can induce cell apoptosis by modulating a GLI1/Bcl-2 (show BCL2 Proteins)/BAX (show BAX Proteins) axis that in turn suppresses HCC (show FAM126A Proteins) progression.
The study demonstrates increased expression of Gli1 and p53 (show TP53 Proteins) in PDAC, and proves that Gli1 could be apotential biomarker for prognostic judgment.
Evidences suggest an indispensable role of GLI1 in the migration and metastasis of breast cancer cells through CXCL12 (show CXCL12 Proteins)/CXCR4 (show CXCR4 Proteins) signaling enhancement.
NFATc1binds the GLI1 promoter and represses its transcription.
low expression of PCAF (show KAT2B Proteins) in hepatocellular carcinoma tissues facilitates tumor cells migration and invasion which is achieved via Gli1-driven epithelial-mesenchymal transition phenotypes.
Immunohistochemical analysis of 122 gliomas showed that TGLI1 expression was positively correlated with VEGF-C (show VEGFC Proteins), TEM7 (show PLXDC1 Proteins) and microvessel density.
Increased SHH (show SHH Proteins), PTCH (show PTCH1 Proteins), and GLI1 protein correlated positively with tumor grade, tumor depth and lymph node metastasis in Peutz-Jeghers syndrome.
Data indicate that regulation of sonic hedgehog (SHh (show SHH Proteins))-GLI family zinc finger 1 (Gli1) signals to migration of pancreatic cancer AsPC-1 Cells through mediating eukaryotic translation initiation factor 5A (EIF5A2 (show EIF5A2 Proteins)) gene expression.
Data indicate that the expression levels of transcription factors Gli1 and Gli2 in muscle were the lowest of the 13 tissues.
Dzip1 (show DZIP1 Proteins)-dependent stabilization of Spop (show SPOP Proteins)/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
Zyxin (show ZYX Proteins) inhibits Shh (show SHH Proteins) signaling during the CNS patterning in Xenopus laevis through interaction with Gli1
a new mechanism of Gli transcription factor activation and implicate ARHGAP36 (show ARHGAP36 Proteins) dysregulation in the onset and/or progression of GLI-dependent cancers.
We show that Kif7 interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 in Drosophila.
Gli1 has a Hh-independent role in many motoneurons and V3 domain cells in embryos that lack Hh signalling, but removal of Gli1 activity does not affect more dorsal neurons.
These results reveal divergent requirements for Gli1 and Gli2 in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 has minor roles as a repressor or activator of Hh targets.
Gli1 regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (show SGPL1 Proteins)) factor activity.
NANOG (show NANOG Proteins) binds to GLI1 and GLI3 (show GLI3 Proteins) proteins and represses Hedgehog (show SHH Proteins)-mediated transcription.
characterization of the contribution to remyelination of a subset of adult neural stem cells, identified by their expression of Gli1, a transcriptional effector of the sonic hedgehog (show SHH Proteins) pathway
the three GLI factors(GLI1, GLI2, and GLI3 (show GLI3 Proteins)) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism
Gli1, a known Ptch (show PTCH1 Proteins) activator, preferentially bound the mutant Ptch (show PTCH1 Proteins) locus in rhabdomyosarcoma.
show that combined targeting of GLI and PI3K/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling can have a synergistic therapeutic effect in cells from a subgroup of chronic lymphocytic leukemia patients
Beta-catenin (show CTNNB1 Proteins) stabilization increases its physical interaction with Gli1.
These findings implicate perivascular Gli1(+) mesenchymal stem cells-like cells as a major cellular origin of organ fibrosis.
Cortical activation of Gli1 protects mice from induction of hepatic encephalopathy. TGFbeta1 (show TGFB1 Proteins) suppresses Gli1 in neurons via SMAD3 (show SMAD3 Proteins) and promotes the neurologic decline.
Ptc1 (show PTCH1 Proteins)-Gli1 signaling deregulation resulting in abnormal loss of glial precursor cells may contribute to a cognition decline in Alzheimer's disease brains.
Gli1+ cells within the suture mesenchyme are an indispensable mesenchymal stem cell population supporting craniofacial bone turnover and injury healing.
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
glioma-associated oncogene 1
, glioma-associated oncogene homolog 1 (zinc finger protein)
, oncogene GLI
, zinc finger protein GLI1
, GLI-Kruppel family member GLI1
, GLI family zinc finger 1, gene 1
, zinc finger DNA binding protein Gli-1
, glioma-associated oncogene homolog
, zinc finger protein 5