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High expression of gli1 is associated with glioma chemoresistance.
High Gli-1 expression is associated with pancreatic cancer.
Our study is the first to demonstrate the associations of high nuclear Gli1 expression with resistance to trastuzumab-based NAT (show BRD2 Proteins) and subsequent worse prognosis in HER2 (show ERBB2 Proteins)-positive disease. These findings suggest that the nuclear Gli1 protein may be a novel target of NAT (show BRD2 Proteins) for HER2 (show ERBB2 Proteins)-positive breast cancer.
GLI is an oncogenic transcription factor in the SHH (show SHH Proteins) pathway, and targeting GLI with GANT61 results in favourable antitumour activity and targeted therapy.
PRMT1 (show PRMT1 Proteins) promoted the methylation of Gli1.
Genetic variant in GLI-1 gene is associated with gallbladder cancer.
Gli1 expression was positively associated with distant metastasis, increased microvessel density, and expression of cell cycle regulators such as p21 (show CDKN1A Proteins), cyclin D1 (show CCND1 Proteins), cyclin E1 (show CCNE1 Proteins), and NF-kappaB (show NFKB1 Proteins) in esophageal squamous cell carcinoma.
Low GLI1 expression is associated with breast cancer.
Knock down of Gli1 by siRNA interference reduced the viability of glioma cells as well as suppressed cell metastasis.
High GLI expression is associated with pancreatic and skin cancers.
Data indicate that the expression levels of transcription factors Gli1 and Gli2 in muscle were the lowest of the 13 tissues.
Dzip1 (show DZIP1 Proteins)-dependent stabilization of Spop (show SPOP Proteins)/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
Zyxin (show ZYX Proteins) inhibits Shh (show SHH Proteins) signaling during the CNS patterning in Xenopus laevis through interaction with Gli1
a new mechanism of Gli transcription factor activation and implicate ARHGAP36 (show ARHGAP36 Proteins) dysregulation in the onset and/or progression of GLI-dependent cancers.
We show that Kif7 interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 in Drosophila.
Gli1 has a Hh-independent role in many motoneurons and V3 domain cells in embryos that lack Hh signalling, but removal of Gli1 activity does not affect more dorsal neurons.
These results reveal divergent requirements for Gli1 and Gli2 in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 has minor roles as a repressor or activator of Hh targets.
Gli1 regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (show SGPL1 Proteins)) factor activity.
NANOG (show NANOG Proteins) binds to GLI1 and GLI3 (show GLI3 Proteins) proteins and represses Hedgehog (show SHH Proteins)-mediated transcription.
characterization of the contribution to remyelination of a subset of adult neural stem cells, identified by their expression of Gli1, a transcriptional effector of the sonic hedgehog (show SHH Proteins) pathway
the three GLI factors(GLI1, GLI2, and GLI3 (show GLI3 Proteins)) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism
Gli1, a known Ptch (show PTCH1 Proteins) activator, preferentially bound the mutant Ptch (show PTCH1 Proteins) locus in rhabdomyosarcoma.
show that combined targeting of GLI and PI3K/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling can have a synergistic therapeutic effect in cells from a subgroup of chronic lymphocytic leukemia patients
Beta-catenin (show CTNNB1 Proteins) stabilization increases its physical interaction with Gli1.
These findings implicate perivascular Gli1(+) mesenchymal stem cells-like cells as a major cellular origin of organ fibrosis.
Cortical activation of Gli1 protects mice from induction of hepatic encephalopathy. TGFbeta1 (show TGFB1 Proteins) suppresses Gli1 in neurons via SMAD3 (show SMAD3 Proteins) and promotes the neurologic decline.
Ptc1 (show PTCH1 Proteins)-Gli1 signaling deregulation resulting in abnormal loss of glial precursor cells may contribute to a cognition decline in Alzheimer's disease brains.
Gli1+ cells within the suture mesenchyme are an indispensable mesenchymal stem cell population supporting craniofacial bone turnover and injury healing.
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
glioma-associated oncogene 1
, glioma-associated oncogene homolog 1 (zinc finger protein)
, oncogene GLI
, zinc finger protein GLI1
, GLI-Kruppel family member GLI1
, GLI family zinc finger 1, gene 1
, zinc finger DNA binding protein Gli-1
, glioma-associated oncogene homolog
, zinc finger protein 5