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Human Indian Hedgehog ELISA Kit for Sandwich ELISA - ABIN418814
Nishimori, Ehata, Suzuki, Katsuno, Miyazono: Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals. in The Journal of biological chemistry 2012
Our results show for the first time that Indian hedgehog does not cause extracellular matrix degradation in healthy ex vivo cartilage or in the presence of IL-1beta (show IL1B ELISA Kits)
The Annexin a2 (show ANXA2 ELISA Kits) Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog (show SHH ELISA Kits) Pathway.
Studies indicate that the hedgehog (show SHH ELISA Kits) (Hh) signaling pathway has become one of the most studied potential therapeutic targets in hematological malignancies.
Findings demonstrated that Ihh promotes human cartilage endplate degeneration.
endogenously produced IHH is playing a critical role in regulating hBMSC chondrogenesis.
Duplication of the upstream IHH regulatory region and a correlation between the phenotype and the implicated regulatory regions in a family with craniosynostosis Philadelphia type.
Data show that the Hh (Hedgehog (show SHH ELISA Kits)) signalling pathway mediates chemoresistance of BCSCs (breast cancer stem cells) and contributes to the outcome in breast cancer patients.
Data suggest that hedgehog (show SHH ELISA Kits) (HH) signaling through transcription factors GLI1 (show GLI1 ELISA Kits) and GLI2 (show GLI2 ELISA Kits) could be required for the maintenance of pregnancy.
Studies indicate that activation of the hedgehog (show SHH ELISA Kits) (Hh) signaling pathway has been observed in several cancer types, including ovarian cancer.
Gene transfer of indian hedgehog protein results in chondrogenic induction of mesenchymal stem cells.
Ihh expression was downregulated in femur epiphyses of Hand1 (show HAND1 ELISA Kits)-overexpressing mice. Hand1 (show HAND1 ELISA Kits) downregulated Ihh gene expression in vitro by inhibiting Runx2 (show RUNX2 ELISA Kits) transactivation of the Ihh proximal promoter.
In organogenesis of the ovary, production of Dhh (show DHH ELISA Kits)/Ihh in granulosa cells requires growth differentiation factor 9 (show GDF9 ELISA Kits) from the oocyte.
C/EBPbeta (show CEBPB ELISA Kits) and RUNX2 (show RUNX2 ELISA Kits) cooperatively stimulate expression of Ihh through direct interactions with a C/EBPbeta (show CEBPB ELISA Kits) binding element, which further promotes hypertrophic differentiation of chondrocytes during the chondrocyte differentiation process.
findings support the protective role of Ihh deletion in surgically induced osteoarthritis
Thyroid hormone (show PTH ELISA Kits) regulates the secondary ossification center initiation and progression via differentiating chondrocytes into bone matrix-producing osteoblasts by stimulating Ihh and Osx (show SP7 ELISA Kits) expression in chondrocytes.
Apc (show APC ELISA Kits) mutant epithelial cells secrete IHH to maintain an intestinal stromal phenotype that is required for adenoma development in mice.
Cbfbeta (show CBFB ELISA Kits) functions in upregulating Ihh expression to promoter chondrocyte proliferation and osteoblast differentiation, and inhibiting PPR (show PTH1R ELISA Kits) expression to enhance chondrocyte differentiation.
Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration disease.
Data indicate Indian hedgehog (Ihh) induces collagen type X COL10A1 (show COL10A1 ELISA Kits) expression and promotes its transcription through Runx2 (show RUNX2 ELISA Kits)/Smad1 (show SMAD1 ELISA Kits) interactions on a specific promoter region.
By a combination of embryological andmolecular approaches the results demonstrated that Indian hedgehog protein signaling drives the migration of neural crest cells by autocrine or paracrine mechanisms.
Considered collectively, the present study suggests that X-bhh evolutionally acquired the function to induce osteogenesis; however, the expression profile of X-bhh in epiphysis is related to the late development of endochondral ossification in X. laevis.
Data indicate that SRY-box containing gene 4 protein (Sox4) is required to limit the extent of Hedgehog (show SHH ELISA Kits) (Hh) signaling during eye development.
Cxcr4a is required for Hh-dependent cell proliferation but not for Hh-dependent patterning
Data showe that hedgehog (Hh) signaling regulates the expression of pth2 transcripts.
This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.
Indian hedgehog homolog
, Indian hedgehog
, indian hedgehog protein-like
, indian hedgehog protein
, banded hedgehog protein
, indian hedgehog homolog
, echidna hedgehog protein
, indian hedgehog B protein