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Human Indian Hedgehog ELISA Kit for Sandwich ELISA - ABIN366545
Reichert, Schmalzl, Prager, Gilbert, Quent, Steinert, Rudert, Nöth: Synergistic effect of Indian hedgehog and bone morphogenetic protein-2 gene transfer to increase the osteogenic potential of human mesenchymal stem cells. in Stem cell research & therapy 2014
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Human Indian Hedgehog ELISA Kit for Sandwich ELISA - ABIN418814
Nishimori, Ehata, Suzuki, Katsuno, Miyazono: Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals. in The Journal of biological chemistry 2012
Studies suggest significance of other signaling aside from hedgehog (show SHH ELISA Kits) in the pathogenesis of basal cell carcinoma (BCC) of the skin.
Gorlin syndrome-derived induced pluripotent stem cells (iPSCs) expressed lower basal levels than control iPSCs of the genes encoding the Hh ligands Indian Hedgehog (IHH) and Sonic Hedgehog (SHH (show SHH ELISA Kits)).
Hedgehog (show SHH ELISA Kits) pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 (show GLI1 ELISA Kits) inhibitors.
CLIC4 (show CLIC4 ELISA Kits) and Ihh could serve as biological markers for the progression, metastasis and/or invasiveness of pancreatic ductal adenocarcinoma.
The serum levels of IHH and SHH (show SHH ELISA Kits) were significantly higher in autistic subjects than those of control subjects. The findings support a correlation between SHH (show SHH ELISA Kits), IHH and BDNF (show BDNF ELISA Kits) in autistic children, suggesting their pathological role in autism.
Our results show for the first time that Indian hedgehog does not cause extracellular matrix degradation in healthy ex vivo cartilage or in the presence of IL-1beta (show IL1B ELISA Kits)
The Annexin a2 (show ANXA2 ELISA Kits) Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog (show SHH ELISA Kits) Pathway.
Studies indicate that the hedgehog (show SHH ELISA Kits) (Hh) signaling pathway has become one of the most studied potential therapeutic targets in hematological malignancies.
Findings demonstrated that Ihh promotes human cartilage endplate degeneration.
endogenously produced IHH is playing a critical role in regulating hBMSC chondrogenesis.
Ihh is regulated by at least 9 enhancers with individual tissue specificities in the digit anlagen, growth plates, skull sutures and fingertips. Consecutive deletions, resulting in growth defects of the skull and long bones, showed that these enhancers function in an additive manner. Duplications caused dose-dependent upregulation and misexpression of Ihh, abnormal phalanges, fusion of sutures and syndactyly.
GPC6 (show GPC6 ELISA Kits) stimulates Hh signaling by binding to Hh and Ptc1 (show PTCH1 ELISA Kits) at the cilium and increasing the interaction of the receptor and ligand to promote the growth of developing long bones.
An accelerated hypertrophic differentiation caused by a disturbed Ihh-PTHrP (show PTHLH ELISA Kits) signaling pathway may lead to a higher bone mineral density in the vertebral bodies of newborn Col (show HDAC1 ELISA Kits) IX -/- mice and, as a result, to the early onset of disc degeneration.
findings thus demonstrate that augmented Ihh signaling is detrimental to craniofacial development, and that finely tuned Ihh signaling is critical for temporomandibular joint formation.
Ihh has an important role in regulating limb mesenchymal cell differentiation
Ihh and PTH1R (show PTH1R ELISA Kits) signaling in limb mesenchyme are both essential to regulate proper development of digit structures, although they appear to use different mechanisms.
Ihh expression was downregulated in femur epiphyses of Hand1 (show HAND1 ELISA Kits)-overexpressing mice. Hand1 (show HAND1 ELISA Kits) downregulated Ihh gene expression in vitro by inhibiting Runx2 (show RUNX2 ELISA Kits) transactivation of the Ihh proximal promoter.
In organogenesis of the ovary, production of Dhh (show DHH ELISA Kits)/Ihh in granulosa cells requires growth differentiation factor 9 (show GDF9 ELISA Kits) from the oocyte.
C/EBPbeta (show CEBPB ELISA Kits) and RUNX2 (show RUNX2 ELISA Kits) cooperatively stimulate expression of Ihh through direct interactions with a C/EBPbeta (show CEBPB ELISA Kits) binding element, which further promotes hypertrophic differentiation of chondrocytes during the chondrocyte differentiation process.
By a combination of embryological andmolecular approaches the results demonstrated that Indian hedgehog protein signaling drives the migration of neural crest cells by autocrine or paracrine mechanisms.
Considered collectively, the present study suggests that X-bhh evolutionally acquired the function to induce osteogenesis; however, the expression profile of X-bhh in epiphysis is related to the late development of endochondral ossification in X. laevis.
Data indicate that SRY-box containing gene 4 protein (Sox4) is required to limit the extent of Hedgehog (show SHH ELISA Kits) (Hh) signaling during eye development.
Cxcr4a is required for Hh-dependent cell proliferation but not for Hh-dependent patterning
Data showe that hedgehog (Hh) signaling regulates the expression of pth2 transcripts.
This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.
Indian hedgehog homolog
, Indian hedgehog
, indian hedgehog protein-like
, indian hedgehog protein
, banded hedgehog protein
, indian hedgehog homolog
, echidna hedgehog protein
, indian hedgehog B protein