Browse our Patched 1 (PTCH1) ELISA Kits

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Patched 1 ELISA Kits (PTCH1)
On are 5 Patched 1 (PTCH1) ELISA Kits from 3 different suppliers available. Additionally we are shipping Patched 1 Antibodies (167) and Patched 1 Proteins (18) and many more products for this protein. A total of 197 Patched 1 products are currently listed.
A230106A15Rik, BCNS, HPE7, lep, mes, NBCCS, patched, patched1, Ptc, Ptc-1, Ptc1, ptc2, Ptch, ptch1, Ptch2, PTCH11, XPtc1
list all ELISA KIts Gene Name GeneID UniProt
PTCH1 5727 Q13635
Rat PTCH1 PTCH1 89830  
PTCH1 19206 Q61115

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Zebrafish Patched 1 (PTCH1) interaction partners

  1. Results demonstrate a direct link between overproliferation and retinal dysplasia in the ptc2-/- juvenile retina and establish ectopic proliferation as the likely cellular underpinning of retinal dysplasia in juvenile ptc2-/- mutants.

  2. The Hedgehog (show SHH ELISA Kits) co-receptors patched1 and patched2 are expressed in regions of the perichondrium that will form bone before the onset of ossification.

  3. The generation and characterization of the ptc1;ptc2 double mutant assigned novel and unexpected functions to the Hh signaling pathway.

  4. Positional cloning of blowout identified a nonsense mutation in patched1, a negative regulator of the Hedgehog (show SHH ELISA Kits) pathway, as the underlying cause of the blowout phenotype.

Human Patched 1 (PTCH1) interaction partners

  1. Nevoid basal cell carcinoma syndrome caused by splicing mutations in the PTCH1 gene.

  2. PTCH1 expression is a promising molecular marker for predicting the imatinib response in chronic myeloid leukemia (show BCL11A ELISA Kits) patients in chronic phase.

  3. the significant increase of blunt-ended, double-stranded DNA breaks, but not other types of DNA breaks, in normal cells from patients with RET/PTC (show RET ELISA Kits)-driven tumors suggests that blunt-ended double-stranded DNA breaks are a preferred substrate for rearrangement formation, and implicate involvement of the non-homologous end joining pathway in the formation of RET/PTC (show RET ELISA Kits) rearrangements.

  4. Thus, our study clearly demonstrated the unique involvement of the two novel PTCH1 splice variants in HH signal transduction.

  5. These data reveal an interaction between the cytoplasmic domains of Ptch1 and that these domains modulate Ptch1 activity but are not essential for regulation of the Hh pathway.

  6. epigenetic silencing of PTCH is a mechanism contributing to chronic lymphocytic leukemia tumorigenesis

  7. PTCH1 mutations contribute to as much as 10% of ODA, identify the SHH (show SHH ELISA Kits) signaling pathway as a novel effector of SOX2 (show SOX2 ELISA Kits) activity during human ocular development, and indicate that ODA is likely the result of overactive SHH (show SHH ELISA Kits) signaling in humans harboring mutations in either PTCH1 or SOX2 (show SOX2 ELISA Kits).

  8. Naevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominantly inherited disorder with primary mutations in the Patched (PTCH1) gene

  9. This is the first report describing a GS-associated ovarian tumor carrying a second hit in the PTCH1 region.

  10. In Nigerian patients with ameloblastoma, moderate and strong expressions for PTCH in ameloblast and stellate reticulum were 78.6% and 60.7% respectively

Cow (Bovine) Patched 1 (PTCH1) interaction partners

  1. study suggests that modifications affecting the Ptch1 cis (show CISH ELISA Kits)-regulatory landscape have contributed to evolutionary diversification of artiodactyl limbs

Mouse (Murine) Patched 1 (PTCH1) interaction partners

  1. Ptch1 required for ductal outgrowth and proper hormone receptor (show NR4A1 ELISA Kits) expression in the mammary epithelium.

  2. Thus, our study clearly demonstrated the unique involvement of the two novel PTCH1 splice variants in HH signal transduction.

  3. These data reveal an interaction between the cytoplasmic domains of Ptch1 and that these domains modulate Ptch1 activity but are not essential for regulation of the Hh pathway.

  4. Data indicate that Sonic hedgehog (Shh (show SHH ELISA Kits)) stimulate branching morphogenesis (BrM (show SMARCA2 ELISA Kits)) and induced synthesis of mRNAs for Ptch1 protein, epidermal growth factor (EGF (show EGF ELISA Kits)) and receptors of the ErbB (show EGFR ELISA Kits) receptors ErbB1 (show EGFR ELISA Kits), ErbB2 (show ERBB2 ELISA Kits) and ErbB3 (show ERBB3 ELISA Kits).

  5. Data show that the ketogenic diet does not affect growth of Ptch1+/-Trp53 (show TP53 ELISA Kits)-/- Hedgehog (show SHH ELISA Kits) (HH) pathway medulloblastoma.

  6. Targeted single gene deletion of Ptch1 in mouse brain causes medulloblastoma.

  7. Transcriptional upregulation of the inhibitory receptor Ptch1 regulates Shh (show SHH ELISA Kits) signaling during neural tube development.

  8. There was a lower degree of DNA-methylation (show HELLS ELISA Kits) in methylation-sensitive CpG regions of the Ptch promoter in RMS compared to normal muscle from heterozygous Ptch animals.

  9. results indicate that whereas ciliary localization of Patched is essential for suppression of Smoothened activation, the primary event enabling Smoothened activation

  10. Dsg2 (show DSG2 ELISA Kits)-mediated hyperproliferation, MEK (show MDK ELISA Kits)/Erk1/2 (show MAPK1/3 ELISA Kits) activation, and accelerated squamous tumor development are enhanced on the Ptc1+/lacZ (show GLB1 ELISA Kits) background.

Patched 1 (PTCH1) Antigen Profile

Antigen Summary

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Alternative names and synonyms associated with Patched 1 (PTCH1)

  • patched 2 (ptch2) Elisa Kit
  • patched 1 (PTCH1) Elisa Kit
  • patched protein-like protein (PTCH1) Elisa Kit
  • patched 1 (ptch1) Elisa Kit
  • patched 1 (Ptch1) Elisa Kit
  • patched homolog 1 (Ptch1) Elisa Kit
  • Protein PTC-1 (ptc-1) Elisa Kit
  • A230106A15Rik Elisa Kit
  • BCNS Elisa Kit
  • HPE7 Elisa Kit
  • lep Elisa Kit
  • mes Elisa Kit
  • NBCCS Elisa Kit
  • patched Elisa Kit
  • patched1 Elisa Kit
  • Ptc Elisa Kit
  • Ptc-1 Elisa Kit
  • Ptc1 Elisa Kit
  • ptc2 Elisa Kit
  • Ptch Elisa Kit
  • ptch1 Elisa Kit
  • Ptch2 Elisa Kit
  • PTCH11 Elisa Kit
  • XPtc1 Elisa Kit

Protein level used designations for Patched 1 (PTCH1) ELISA Kits

blowout , blw , etID309849.2 , patched 1 , protein patched homolog 1 , patched homolog 1 , patched protein-like protein , patched-like , protein patched homolog 1-like , PTC1 , patched protein , patched-like protein , PTCH protein +12b , PTCH protein +4' , PTCH protein -10 , PTCH protein -3,4,5 , patched homolog 2 , leprechaun , patched 2 , patched-1 , Patched 1 , Ptch1 protein +12b , mesenchymal dysplasia

30181 Danio rerio
465254 Pan troglodytes
718751 Macaca mulatta
7230532 Branchiostoma floridae
100033936 Equus caballus
100345046 Oryctolagus cuniculus
100475966 Ailuropoda melanoleuca
100492061 Xenopus (Silurana) tropicalis
100581789 Nomascus leucogenys
395806 Gallus gallus
5727 Homo sapiens
89830 Rattus norvegicus
30189 Danio rerio
484137 Canis lupus familiaris
100627504 Sus scrofa
520994 Bos taurus
398215 Xenopus laevis
19206 Mus musculus
174274 Caenorhabditis elegans
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