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Patched 1 Products

(Patched 1 (PTCH1))
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq, Jul 2008].

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Featured Patched 1 Categories

Patched 1 Antibodies

High quality antibodies with extensive validation data.

Patched 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Patched 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Patched 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application ELISA, IHC, IF
Validations
  • (2)
  • (7)
Cat. No. ABIN185521
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (6)
Cat. No. ABIN7255007
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (8)
Cat. No. ABIN3015343
Quantity 100 μL
Datasheet Datasheet

Recommended Patched 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958422
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381402
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1152106
Quantity 96 tests
Datasheet Datasheet

Recommended Patched 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316702
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1316700
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505336
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Patched 1 products

Hasanovic, Ruggiero, Jung, Rapa, Signetti, Ben Hadj, Terzolo, Beuschlein, Volante, Hantel, Lalli, Mus-Veteau: "Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma in vitro and in vivo." in: International journal of cancer, Vol. 143, Issue 1, pp. 199-211, (2019) (PubMed).

Takeuchi, Kito, Itoh, Naruse, Fujikawa, Sadek, Akiyama, Yamashiro, Wakisaka, Abe: "Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling." in: Experimental cell research, Vol. 371, Issue 2, pp. 417-425, (2018) (PubMed).

Wetendorf, Wu, Wang, Creighton, Wang, Lanz, Blok, Tsai, Tsai, Lydon, DeMayo: "Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment." in: Biology of reproduction, Vol. 96, Issue 2, pp. 313-326, (2017) (PubMed).

Zhang, Nan, Song, Wang, Si, Li: "Knockdown of HIF-1α inhibits the proliferation and migration of outer root sheath cells exposed to hypoxia in vitro: An involvement of Shh pathway." in: Life sciences, Vol. 191, pp. 82-89, (2017) (PubMed).

Wang, Song, Anbarchian, Shirazyan, Sadik, Lyons: "Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate." in: PLoS genetics, Vol. 12, Issue 10, pp. e1006352, (2016) (PubMed).

Meerang, Bérard, Felley-Bosco, Lauk, Vrugt, Boss, Kenkel, Broggini-Tenzer, Stahel, Arni, Weder, Opitz: "Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma." in: Molecular cancer therapeutics, Vol. 15, Issue 5, pp. 1095-105, (2016) (PubMed).

Martinez, Kobayashi, Krishnan, Webber, Christie, Guo, Singh, Zochodne: "Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen." in: Experimental neurology, Vol. 271, pp. 493-505, (2015) (PubMed).

Xie, Zhang, Chen, Xie, Chen, Cheng, Zhou, Chen: "Developmental Status: Impact of Short-Term Ischemia on Follicular Survival of Whole Ovarian Transplantation in a Rabbit Model." in: PLoS ONE, Vol. 10, Issue 8, pp. e0135049, (2015) (PubMed).

Abiria, Williams, Munden, Grover, Wallace, Lundberg, Valadez, Cooper: "Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling." in: Journal of neuro-oncology, Vol. 119, Issue 2, pp. 243-51, (2014) (PubMed).

Jeng, Sheen, Jeng, Yu, Hsiau, Chang: "High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma." in: OncoTargets and therapy, Vol. 7, pp. 79-86, (2014) (PubMed).

Synonyms and alternative names related to Patched 1

patched 1 (PTCH1), patched 1 (ptch1), patched 1 (Ptch1), patched 1 L homeolog (ptch1.L), Protein patched homolog 1 (ptc-1), A230106A15Rik, BCNS, HPE7, lep, mes, NBCCS, patched, patched1, PTC, Ptc, Ptc-1, PTC1, ptc1, Ptc1, ptc2, PTCH, Ptch, Ptch2, PTCH11, XPtc1

Protein level used designations for Patched 1

  • PTCH protein +12b
  • PTCH protein +4'
  • PTCH protein -10
  • PTCH protein -3,4,5
  • protein patched homolog 1
  • leprechaun
  • patched 2
  • patched homolog 2
  • patched homolog 1
  • patched-1
  • patched 1
  • patched-like
  • protein patched homolog 1-like
  • Patched 1
  • Ptch1 protein +12b
  • mesenchymal dysplasia
  • PTC1
  • patched protein
  • patched-like protein
  • LOW QUALITY PROTEIN: protein patched homolog 1
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