Browse our anti-Sonic Hedgehog (SHH) Antibodies

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anti-Sonic Hedgehog Antibodies (SHH)
On are 139 Sonic Hedgehog (SHH) Antibodies from 27 different suppliers available. Additionally we are shipping Sonic Hedgehog Proteins (88) and Sonic Hedgehog Kits (25) and many more products for this protein. A total of 261 Sonic Hedgehog products are currently listed.
9530036O11Rik, Dsh, fc83d08, hedgehog, HHG1, HLP3, HPE3, Hx, Hxl3, M100081, MCOPCB5, SHH, SMMCI, syu, TPT, TPTPS, vhh-1, vhh1, wu:fc83d08, Xhh, xshh

Most Popular Reactivities for anti-Sonic Hedgehog (SHH) Antibodies

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anti-Mouse (Murine) Sonic Hedgehog Antibodies:

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Top referenced anti-Sonic Hedgehog Antibodies

  1. Human Polyclonal Sonic Hedgehog Primary Antibody for IF (p), IHC (p) - ABIN731108 : Weiss, Guo, Shan, Shi, Romano, Sinha, Cantley, Guo: Brg1 determines urothelial cell fate during ureter development. in Journal of the American Society of Nephrology : JASN 2013 (PubMed)
    Show all 7 references for 731108

  2. Human Monoclonal Sonic Hedgehog Primary Antibody for ELISA - ABIN393243 : Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. in PLoS ONE 2010 (PubMed)
    Show all 5 references for 393243

  3. Human Monoclonal Sonic Hedgehog Primary Antibody for ELISA, WB - ABIN969395 : Dierker, Dreier, Migone, Hamer, Grobe: Heparan sulfate and transglutaminase activity are required for the formation of covalently cross-linked hedgehog oligomers. in The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for 969395

  4. Human Monoclonal Sonic Hedgehog Primary Antibody for FACS - ABIN4897996 : Blotta, Jakubikova, Calimeri, Roccaro, Amodio, Azab, Foresta, Mitsiades, Rossi, Todoerti, Molica, Morabito, Neri, Tagliaferri, Tassone, Anderson, Munshi: Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma. in Blood 2012 (PubMed)
    Show all 2 references for 4897996

  5. Human Monoclonal Sonic Hedgehog Primary Antibody for ELISA, FACS - ABIN4355158 : Valverde, Pereira, Dias, Guimarães, Ramos, Santos, Gurgel Rocha: Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation. in Tumour biology 2016 (PubMed)
    Show all 2 references for 4355158

  6. Cow (Bovine) Polyclonal Sonic Hedgehog Primary Antibody for IHC, WB - ABIN2781775 : Coon, Roberts, Loscertales, Kradin: Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia. in Experimental and molecular pathology 2006 (PubMed)

  7. Human Monoclonal Sonic Hedgehog Primary Antibody for FACS, IHC - ABIN969567 : Kameda, Nakamura, Tanaka, Yamasaki, Kubo, Tanaka, Onishi, Katano: Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. in British journal of cancer 2010 (PubMed)

  8. Chicken Polyclonal Sonic Hedgehog Primary Antibody for IHC, IHC (p) - ABIN4893080 : Lozito, Tuan: Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration. in Development (Cambridge, England) 2016 (PubMed)

More Antibodies against Sonic Hedgehog Interaction Partners

Mouse (Murine) Sonic Hedgehog (SHH) interaction partners

  1. sonic hedgehog signaling activity influences clonal spatial distribution of thalamic neurons.

  2. Both the number of lung CD31 (show PECAM1 Antibodies)-CD45 (show PTPRC Antibodies)-Sca-1 (show Ly6a Antibodies)+ cells and the expression levels of the Shh signaling pathway were downregulated in the lung tissues of mice with pulmonary emphysema. These cells and Shh signaling pathway are reactivated during acute adenovirus infection.

  3. We show that retinoic acid promotes, whereas SHH, acting strictly within the lingual epithelium, inhibits taste placode and lingual gland formation by thwarting RA activity.

  4. Our results suggest that Shh contributes to the development of epilepsy and suppression of its signaling prevents the development of the disease. Thus, Shh can act as a modulator of neuronal activity, rapidly regulating glutamate (show GRIN1 Antibodies) levels and promoting epilepsy.

  5. YB-1 (show YBX1 Antibodies) is induced by Shh in CGNPs

  6. Shh and Sort1 (show SORT1 Antibodies) can interact at the level of the Golgi and that Sort1 (show SORT1 Antibodies) directs Shh away from the pathways that promote its secretion.

  7. Sufu (show SUFUH Antibodies) is upregulated in active Shh responding tissues and accompanies Gli (show GLI1 Antibodies) activators translocating into and Gli (show GLI1 Antibodies) repressors out of the nucleus.

  8. Tbx2 (show TBX2 Antibodies) and Tbx3 (show TBX3 Antibodies) function downstream of Shh to maintain pro-proliferative mesenchymal Wnt (show WNT2 Antibodies) signaling.

  9. cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH signaling through regulation of GLI3 (show GLI3 Antibodies) processing.

  10. Activated microglia are major cell type for SHH expression in vivo and in vitro.

Human Sonic Hedgehog (SHH) interaction partners

  1. YB-1 (show YBX1 Antibodies) is induced by Shh in CGNPs

  2. SHH siRNA synergistically enhanced cytotoxicity induced by itraconazole in MCF-7 cells.

  3. Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 (show GLI1 Antibodies) inhibitors.

  4. Data suggest that negative feedback mediated by GLI3 (show GLI3 Antibodies) (GLI (show GLI1 Antibodies)-Kruppel family member) acts to finely tune SHH (sonic hedgehog) signaling. During medulloblastoma (MB) formation, nerve tissue cells appear to express nestin (show NES Antibodies) which hyperactivates SHH signaling by abolishing negative feedback by GLI3 (show GLI3 Antibodies). Restoration of intrinsic negative feedback by repressing nestin (show NES Antibodies) expression represents a promising approach to treat MB. [REVIEW]

  5. The study reveals several novel individual and repetitive mutations of SHH gene in Gallbladder Cancer and Cholelithiasis samples that may be used as diagnostic markers for gallbladder carcinogenesis.

  6. Data indicate that agedunin induces its anti-metastatic effect through inhibition of sonic hedgehog protein [SHH] signaling.

  7. findings suggest that Usp7 (show USP7 Antibodies) is important for MB cell proliferation and metastasis by activating Shh pathway, and is a putative therapeutic target for MBs (show PPP1R12A Antibodies)

  8. importance of MAOA (show MAOA Antibodies) for initiating the pre-metastatic niche in stromal cells and promoting PCa (show FLVCR1 Antibodies) metastasis to bone and visceral organs, mediated by activation of paracrine Shh-IL6 (show IL6 Antibodies)-RANKL (show TNFSF11 Antibodies) signaling underlying tumor-stromal interactions.

  9. Studies indicate that sonic hedgehog protein (Shh) is upregulated specifically in renal tubular epithelium.

  10. these results reveal a novel role for E177-Zn(2+) in regulating SHH signaling that may involve critical, cilia basal-body localized changes in cross-linking and/or conformation.

Xenopus laevis Sonic Hedgehog (SHH) interaction partners

  1. Data indicate that sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of the regenerate.

  2. Dzip1 (show DZIP1 Antibodies)-dependent stabilization of Spop (show SPOP Antibodies)/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Antibodies)/Ci proteins in the Hh pathway.

  3. Notch (show NOTCH1 Antibodies) signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline.

  4. These results indicate that electrical activity and second-messenger signaling mediate Shh action in embryonic spinal neurons.

  5. Connective tissue-specific expression of BMP-4 (show BMP4 Antibodies) mRNA is up-regulated by sonic hedgehog.

  6. In an examination of signaling pathways in developing Xenopus lung, shh but not ihh (show IHH Antibodies) was expressed in the very anterior part of early lung epithelium.

  7. Data propose that Shh serves as a ventral optic tract repellent that helps to define the caudal (show CAD Antibodies) boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.

  8. The forebrain of Xenopus revealed a largely conserved pattern of Shh expression among tetrapods.

  9. Hedgehog regulates superficial slow muscle fibres in Xenopus and tetrapod trunk myogenesis

  10. Results suggest that 7-dehydrocholesterol reductase (show DHCR7 Antibodies) and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos

Cow (Bovine) Sonic Hedgehog (SHH) interaction partners

  1. study shows evolutionary alteration of a Ptch1 (show PTCH1 Antibodies) cis (show CISH Antibodies)-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development

Zebrafish Sonic Hedgehog (SHH) interaction partners

  1. Shh is not essential for the early activation of has2 (show HAS2 Antibodies), but supports proper chondrogenic differentiation.

  2. Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.

  3. Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis

  4. Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity.

  5. We further demonstrate that the elevated Hedgehog signaling in Sox11 (show SOX11 Antibodies)-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 (show SOX11 Antibodies) morphants.

  6. Pax6 (show PAX6 Antibodies) has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates.

  7. Sulf1 (show SULF1 Antibodies) triggers Shh signaling activity to establish and, later on, modify the spatial arrangement of gene expression in ventral neural progenitors

  8. These studies provide evidence that a signaling pathway involving agrin (show AGRN Antibodies), Fgfs and Shh may be a critical target of ethanol exposure during zebrafish embryogenesis.

  9. heterozygote mutations in fgf8 (show FGF8 Antibodies), shh or oep (show TDGF1 Antibodies) lead to a reduced number of ascending dopaminergic neurons in zebrafish and may confer increased susceptibility to the Parkinson disease

  10. Hh is able to bypass VEGF to induce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surprising complexity in the interplay between Hh and VEGF signaling during arteriovenous specification.

Sonic Hedgehog (SHH) Antigen Profile

Antigen Summary

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

Alternative names and synonyms associated with Sonic Hedgehog (SHH)

  • sonic hedgehog (shh) antibody
  • sonic hedgehog (SHH) antibody
  • sonic hedgehog (LOC100352774) antibody
  • sonic hedgehog (Shh) antibody
  • sonic hedgehog a (shha) antibody
  • 9530036O11Rik antibody
  • Dsh antibody
  • fc83d08 antibody
  • hedgehog antibody
  • HHG1 antibody
  • HLP3 antibody
  • HPE3 antibody
  • Hx antibody
  • Hxl3 antibody
  • M100081 antibody
  • MCOPCB5 antibody
  • SHH antibody
  • SMMCI antibody
  • syu antibody
  • TPT antibody
  • TPTPS antibody
  • vhh-1 antibody
  • vhh1 antibody
  • wu:fc83d08 antibody
  • Xhh antibody
  • xshh antibody

Protein level used designations for anti-Sonic Hedgehog (SHH) Antibodies

sonic hedgehog protein , sonic hedgehog , HHG-1 , hemimelic extra toes , short digits , sonic hedgehog homolog , VHH-1 , X-SHH , morphogen , sonic hedgehog protein A , sonic-you

446055 Takifugu rubripes
100049186 Oryzias latipes
100136227 Oncorhynchus mykiss
100169727 Felis catus
100352774 Oryctolagus cuniculus
100505407 Sus scrofa
20423 Mus musculus
6469 Homo sapiens
398047 Xenopus laevis
395615 Gallus gallus
608860 Canis lupus familiaris
29499 Rattus norvegicus
286821 Bos taurus
30269 Danio rerio
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