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Mouse (Murine) Sonic Hedgehog ELISA Kit for Sandwich ELISA - ABIN851745
Li, Han, Lin, He, Yu, Zhao: Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum. in Evidence-based complementary and alternative medicine : eCAM 2015
Human Sonic Hedgehog ELISA Kit for Sandwich ELISA - ABIN366604
Filges, Röthlisberger, Blattner, Boesch, Demougin, Wenzel, Huber, Heinimann, Weber, Miny: Deletion in Xp22.11: PTCHD1 is a candidate gene for X-linked intellectual disability with or without autism. in Clinical genetics 2010
Human Sonic Hedgehog ELISA Kit for Sandwich ELISA - ABIN625086
Cigna, Farrokhi Moshai, Brayer, Marchal-Somme, Wémeau-Stervinou, Fabre, Mal, Lesèche, Dehoux, Soler, Crestani, Mailleux: The hedgehog system machinery controls transforming growth factor-?-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis. in The American journal of pathology 2012
These results support a model whereby mutations in Cdon (show CDON ELISA Kits) and prenatal ethanol exposure increase Septo-optic dysplasia risk through spatiotemporal perturbations in Shh signaling activity.
Results report the identification of a novel long-range enhancer for Shh-Shh-brain-enhancer-6 (SBE6)-that is located 100 kb upstream of Shh and that is required for the proper induction of Shh expression during this differentiation program.
neuroectodermal Shh expression, dorsal/ventral patterning, and amount of proliferation in the ventral neuroectoderm was not changed in Wnt1 (show WNT1 ELISA Kits)-Cre;Kif3a (show KIF3A ELISA Kits)(fl/fl (show FLT3LG ELISA Kits)) mutants; however, tissue polarity and directional cell division were disrupted.
The authors find that cholesterol, an important component of the cell membrane, directly binds to Smoothened and changes its shape so that it can activate Hedgehog signaling components inside cells.
Embryonal tumors with multilayered rosettes (ETMRs) are characterized by a parallel activation of Shh and Wnt (show WNT2 ELISA Kits) signaling. Co-activation of these pathways in mouse neural precursors is sufficient to induce ETMR-like tumors in vivo that resemble their human counterparts on the basis of histology and global gene-expression analyses, and that point to apical radial glia cells as the possible tumor cell of origin.
reactivating SHH signaling in mutant lungs rescued the tip dilation phenotype and attenuated FGF signaling. Importantly, the reduced SHH signaling activity did not appear to be caused by decreased Shh expression or protein stability; instead, biologically active form of SHH proteins were reduced in both the Ext1 (show EXT1 ELISA Kits) mutant epithelium and surrounding wild type mesenchymal cells.
provide compelling evidence that epidermal YAP (show YAP1 ELISA Kits) and Hedgehog/GLI2 (show GLI2 ELISA Kits) signalling undergo positive regulatory interactions in the control of normal epidermal homeostasis and in basal cell carcinoma (BCC) development, which in the large majority of cases is caused by aberrant Hedgehog signalling activity
conditional deletion of Shh in the anterior hypothalamus results in a fully penetrant phenotype characterised by a complete arrest of (Rathke's pouch) RP development, with lack of Lhx3 (show LHX3 ELISA Kits)/Lhx4 (show LHX4 ELISA Kits) expression in RP epithelium.
Shh production and Gli (show GLI1 ELISA Kits) signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma
Shh is in part responsible for the dependence of taste cell renewal on gustatory innervation, neurotrophic support of taste buds likely involves a complex set of factors.
High SHH expression is associated with esophageal squamous cell carcinoma.
Studies suggest significance of other signaling aside from hedgehog in the pathogenesis of basal cell carcinoma (BCC) of the skin.
Gorlin syndrome-derived induced pluripotent stem cells (iPSCs) expressed lower basal levels than control iPSCs of the genes encoding the Hh ligands Indian Hedgehog (IHH (show IHH ELISA Kits)) and Sonic Hedgehog (SHH).
SHH activation is associated with Rhabdomyosarcoma.
Studies suggest that embryonic signaling pathways, the likes of Notch (show NOTCH1 ELISA Kits), Wnt (show WNT2 ELISA Kits), and Hedgehog and tumor marker Oct-4 (show POU5F1 ELISA Kits) offer targets for cascade-specific molecular inhibition as they are fundamental to (cancer and normal) stem cell maintenance and growth.
Methylation at K436 and K595 respectively by Set7 (show SETD7 ELISA Kits) increases the stability and DNA binding ability of Gli3 (show GLI3 ELISA Kits), resulting in an enhancement of Shh signaling activation.
Altogether, these data suggested that curcumin inhibited the activities of BCSCs through suppressing Shh pathway, which might be an effective chemopreventive agent for bladder cancer intervention.
High SHH expression is associated with Small Cell Lung Cancer.
Accumulating evidence suggest that cytochrome P450 (show CYP ELISA Kits) (CYP26 (show CYP26A1 ELISA Kits)), the primary retinoid-inactivating enzyme, plays a critical role in the integration of two neoplastic molecular programs: the retinoid metabolism and Hedgehog pathways. (Review)
CHSY1 (show CHSY1 ELISA Kits) overexpression in HCC (show FAM126A ELISA Kits) contributes to the malignant behavior of hepatocellular carcinoma cells via activation of the hedgehog signaling pathway.
Data indicate that sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of the regenerate.
Dzip1-dependent stabilization of Spop (show SPOP ELISA Kits)/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 ELISA Kits)/Ci proteins in the Hh pathway.
Notch (show NOTCH1 ELISA Kits) signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline.
These results indicate that electrical activity and second-messenger signaling mediate Shh action in embryonic spinal neurons.
Connective tissue-specific expression of BMP-4 (show BMP4 ELISA Kits) mRNA is up-regulated by sonic hedgehog.
In an examination of signaling pathways in developing Xenopus lung, shh but not ihh (show IHH ELISA Kits) was expressed in the very anterior part of early lung epithelium.
Data propose that Shh serves as a ventral optic tract repellent that helps to define the caudal (show CAD ELISA Kits) boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.
The forebrain of Xenopus revealed a largely conserved pattern of Shh expression among tetrapods.
Hedgehog regulates superficial slow muscle fibres in Xenopus and tetrapod trunk myogenesis
Results suggest that 7-dehydrocholesterol reductase (show DHCR7 ELISA Kits) and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos
study shows evolutionary alteration of a Ptch1 (show PTCH1 ELISA Kits) cis (show CISH ELISA Kits)-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development
Mutation of hmgcs1 (show HMGCS1 ELISA Kits) had no effect on Shh signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1 (show GLI1 ELISA Kits), a known Shh target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 (show HMGCS1 ELISA Kits) mutants.
Shha/Smo is functionally dedicated to ray branching during fin regeneration.
Shh and Rx3 govern formation of a distinct progenitor domain that elaborates patterning through its anisotropic growth and differentiation.
Time-lapse imaging revealed that knockdown of miR (show MYLIP ELISA Kits)-219 function accelerates the growth of primary cilia, revealing a possible mechanistic link between miR (show MYLIP ELISA Kits)-219-mediated regulation of apical Par (show AFG3L2 ELISA Kits) proteins and Shh signaling.
Shh is not essential for the early activation of has2 (show HAS2 ELISA Kits), but supports proper chondrogenic differentiation.
Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.
Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis
Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity.
We further demonstrate that the elevated Hedgehog signaling in Sox11 (show SOX11 ELISA Kits)-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 (show SOX11 ELISA Kits) morphants.
Pax6 (show PAX6 ELISA Kits) has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates.
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.
sonic hedgehog protein
, sonic hedgehog
, hemimelic extra toes
, short digits
, sonic hedgehog homolog
, sonic hedgehog protein A