Browse our Sonic Hedgehog Proteins (SHH)

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Sonic Hedgehog Proteins (SHH)
On www.antibodies-online.com are 96 Sonic Hedgehog (SHH) Proteins from 19 different suppliers available. Additionally we are shipping Sonic Hedgehog Antibodies (145) and Sonic Hedgehog Kits (47) and many more products for this protein. A total of 297 Sonic Hedgehog products are currently listed.
Synonyms:
9530036O11Rik, Dsh, fc83d08, hedgehog, HHG1, HLP3, HPE3, Hx, Hxl3, M100081, MCOPCB5, SHH, SMMCI, syu, TPT, TPTPS, vhh-1, vhh1, wu:fc83d08, Xhh, xshh
list all proteins Gene Name GeneID UniProt
SHH 20423 Q62226
SHH 6469 Q15465
SHH 29499 Q63673

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Sonic Hedgehog Proteins (SHH) by Origin

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Top referenced Sonic Hedgehog Proteins

  1. Human Sonic Hedgehog Protein expressed in HEK-293 Cells - ABIN2181760 : Pepinsky, Zeng, Wen, Rayhorn, Baker, Williams, Bixler, Ambrose, Garber, Miatkowski, Taylor, Wang, Galdes: Identification of a palmitic acid-modified form of human Sonic hedgehog. in The Journal of biological chemistry 1998 (PubMed)
    Show all 2 references for 2181760

  2. Mouse (Murine) Sonic Hedgehog Protein expressed in Human Cells - ABIN2008611 : Stone, Hynes, Armanini, Swanson, Gu, Johnson, Scott, Pennica, Goddard, Phillips, Noll, Hooper, de Sauvage, Rosenthal: The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. in Nature 1996 (PubMed)
    Show all 2 references for 2008611

  3. Human Sonic Hedgehog Protein expressed in Human Cells - ABIN2002696 : Ericson, Briscoe, Rashbass, van Heyningen, Jessell: Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube. in Cold Spring Harbor symposia on quantitative biology 1998 (PubMed)
    Show all 2 references for 2002696

More Proteins for Sonic Hedgehog Interaction Partners

Mouse (Murine) Sonic Hedgehog (SHH) interaction partners

  1. Data indicate odd-skipped related protein 1 (Osr1 (show OSR1 Proteins)) as a mediator of Hedgehog (HH) signaling during foregut organogenesis.

  2. direct targeting of Foxf2 (show FOXF2 Proteins) by Shh signaling drives cranial neural crest cell mesenchyme proliferation during upper lip morphogenesis, and disruption of this sequence results in cleft lip.

  3. Dicer1 ablation impairs Shh-induced granule neuron precursor proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17 approximately 92 cluster members. This study establishes a molecular link between miRNAs and cell cycle progression in the proliferating Granule neuron precursors during normal cerebellar development and may facilitate miRNA application in treating med...

  4. Expression of Bmp4 (show BMP4 Proteins) in the ureteric mesenchyme depends on HH signaling and Foxf1 (show FOXF1 Proteins), and that exogenous BMP4 (show BMP4 Proteins) rescued cell proliferation and epithelial differentiation in ureters with abrogated HH signaling or FOXF1 (show FOXF1 Proteins) function.

  5. A model in which SHH signaling plays both positive and negative roles in patterning and organogenesis of the thymus and parathyroids.

  6. This suggests an important cross-talk between SHH and WIP1 pathways that accelerates tumorigenesis and supports WIP1 inhibition as a potential treatment strategy for MB.

  7. High SHH expression is associated with Medulloblastoma.

  8. sonic hedgehog signaling activity influences clonal spatial distribution of thalamic neurons.

  9. Both the number of lung CD31 (show PECAM1 Proteins)-CD45 (show PTPRC Proteins)-Sca-1+ cells and the expression levels of the Shh signaling pathway were downregulated in the lung tissues of mice with pulmonary emphysema. These cells and Shh signaling pathway are reactivated during acute adenovirus infection.

  10. We show that retinoic acid promotes, whereas SHH, acting strictly within the lingual epithelium, inhibits taste placode and lingual gland formation by thwarting RA activity.

Human Sonic Hedgehog (SHH) interaction partners

  1. CHSY1 (show CHSY1 Proteins) overexpression in HCC (show FAM126A Proteins) contributes to the malignant behavior of hepatocellular carcinoma cells via activation of the hedgehog signaling pathway.

  2. We found a novel 7q36.3 duplication involving 2 genes (SHH and RBM33) in a patient with complete corpus callosum agenesis (Figure), moderate learning difficulties, and macrocephaly

  3. Study showed that SHH expression was significantly high among breast cancer patients with advanced tumor grade, stage, nodal involvement and metastasis and this expression strongly correlated with proliferation marker.

  4. This suggests an important cross-talk between SHH and WIP1 pathways that accelerates tumorigenesis and supports WIP1 inhibition as a potential treatment strategy for MB.

  5. YB-1 (show YBX1 Proteins) is induced by Shh in CGNPs

  6. SHH siRNA synergistically enhanced cytotoxicity induced by itraconazole in MCF-7 cells.

  7. Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 (show GLI1 Proteins) inhibitors.

  8. Data suggest that negative feedback mediated by GLI3 (show GLI3 Proteins) (GLI (show GLI1 Proteins)-Kruppel family member) acts to finely tune SHH (sonic hedgehog) signaling. During medulloblastoma (MB) formation, nerve tissue cells appear to express nestin (show NES Proteins) which hyperactivates SHH signaling by abolishing negative feedback by GLI3 (show GLI3 Proteins). Restoration of intrinsic negative feedback by repressing nestin (show NES Proteins) expression represents a promising approach to treat MB. [REVIEW]

  9. The study reveals several novel individual and repetitive mutations of SHH gene in Gallbladder Cancer and Cholelithiasis samples that may be used as diagnostic markers for gallbladder carcinogenesis.

  10. Data indicate that agedunin induces its anti-metastatic effect through inhibition of sonic hedgehog protein [SHH] signaling.

Xenopus laevis Sonic Hedgehog (SHH) interaction partners

  1. Data indicate that sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of the regenerate.

  2. Dzip1 (show DZIP1 Proteins)-dependent stabilization of Spop (show SPOP Proteins)/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Proteins)/Ci proteins in the Hh pathway.

  3. Notch (show NOTCH1 Proteins) signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline.

  4. These results indicate that electrical activity and second-messenger signaling mediate Shh action in embryonic spinal neurons.

  5. Connective tissue-specific expression of BMP-4 (show BMP4 Proteins) mRNA is up-regulated by sonic hedgehog.

  6. In an examination of signaling pathways in developing Xenopus lung, shh but not ihh (show IHH Proteins) was expressed in the very anterior part of early lung epithelium.

  7. Data propose that Shh serves as a ventral optic tract repellent that helps to define the caudal boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.

  8. The forebrain of Xenopus revealed a largely conserved pattern of Shh expression among tetrapods.

  9. Hedgehog regulates superficial slow muscle fibres in Xenopus and tetrapod trunk myogenesis

  10. Results suggest that 7-dehydrocholesterol reductase (show DHCR7 Proteins) and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos

Cow (Bovine) Sonic Hedgehog (SHH) interaction partners

  1. study shows evolutionary alteration of a Ptch1 (show PTCH1 Proteins) cis (show CISH Proteins)-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development

Zebrafish Sonic Hedgehog (SHH) interaction partners

  1. Mutation of hmgcs1 (show HMGCS1 Proteins) had no effect on Shh signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1 (show GLI1 Proteins), a known Shh target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 (show HMGCS1 Proteins) mutants.

  2. Shha/Smo is functionally dedicated to ray branching during fin regeneration.

  3. Shh and Rx3 govern formation of a distinct progenitor domain that elaborates patterning through its anisotropic growth and differentiation.

  4. Time-lapse imaging revealed that knockdown of miR (show MYLIP Proteins)-219 function accelerates the growth of primary cilia, revealing a possible mechanistic link between miR (show MYLIP Proteins)-219-mediated regulation of apical Par (show AFG3L2 Proteins) proteins and Shh signaling.

  5. Shh is not essential for the early activation of has2 (show HAS2 Proteins), but supports proper chondrogenic differentiation.

  6. Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.

  7. Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis

  8. Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity.

  9. We further demonstrate that the elevated Hedgehog signaling in Sox11 (show SOX11 Proteins)-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 (show SOX11 Proteins) morphants.

  10. Pax6 (show PAX6 Proteins) has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates.

Sonic Hedgehog (SHH) Protein Profile

Protein Summary

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

Alternative names and synonyms associated with Sonic Hedgehog (SHH)

  • sonic hedgehog (shh)
  • sonic hedgehog (SHH)
  • sonic hedgehog (LOC100352774)
  • sonic hedgehog (Shh)
  • sonic hedgehog a (shha)
  • 9530036O11Rik protein
  • Dsh protein
  • fc83d08 protein
  • hedgehog protein
  • HHG1 protein
  • HLP3 protein
  • HPE3 protein
  • Hx protein
  • Hxl3 protein
  • M100081 protein
  • MCOPCB5 protein
  • SHH protein
  • SMMCI protein
  • syu protein
  • TPT protein
  • TPTPS protein
  • vhh-1 protein
  • vhh1 protein
  • wu:fc83d08 protein
  • Xhh protein
  • xshh protein

Protein level used designations for Sonic Hedgehog Proteins (SHH)

sonic hedgehog protein , sonic hedgehog , HHG-1 , hemimelic extra toes , short digits , sonic hedgehog homolog , VHH-1 , X-SHH , morphogen , sonic hedgehog protein A , sonic-you

GENE ID SPECIES
446055 Takifugu rubripes
100049186 Oryzias latipes
100136227 Oncorhynchus mykiss
100169727 Felis catus
100352774 Oryctolagus cuniculus
100505407 Sus scrofa
20423 Mus musculus
6469 Homo sapiens
398047 Xenopus laevis
395615 Gallus gallus
608860 Canis lupus familiaris
29499 Rattus norvegicus
286821 Bos taurus
30269 Danio rerio
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