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Browse our Sonic Hedgehog Proteins (SHH)

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Sonic Hedgehog Proteins (SHH)
On are 87 Sonic Hedgehog (SHH) Proteins from 17 different suppliers available. Additionally we are shipping Sonic Hedgehog Antibodies (136) and Sonic Hedgehog Kits (18) and many more products for this protein. A total of 250 Sonic Hedgehog products are currently listed.
9530036O11Rik, Dsh, fc83d08, hedgehog, HHG1, HLP3, HPE3, Hx, Hxl3, M100081, MCOPCB5, SHH, SMMCI, syu, TPT, TPTPS, vhh-1, vhh1, wu:fc83d08, Xhh, xshh
list all proteins Gene Name GeneID UniProt
SHH 20423 Q62226
SHH 6469 Q15465
SHH 29499 Q63673

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Sonic Hedgehog Proteins (SHH) by Origin

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Top referenced Sonic Hedgehog Proteins

  1. Human Sonic Hedgehog Protein expressed in Escherichia coli (E. coli) - ABIN2666482 : Ingham, McMahon: Hedgehog signaling in animal development: paradigms and principles. in Genes & development 2001 (PubMed)
    Show all 5 references for ABIN2666482

  2. Human Sonic Hedgehog Protein expressed in HEK-293 Cells - ABIN2181760 : Pepinsky, Zeng, Wen, Rayhorn, Baker, Williams, Bixler, Ambrose, Garber, Miatkowski, Taylor, Wang, Galdes: Identification of a palmitic acid-modified form of human Sonic hedgehog. in The Journal of biological chemistry 1998 (PubMed)
    Show all 2 references for ABIN2181760

  3. Human Sonic Hedgehog Protein expressed in Escherichia coli (E. coli) - ABIN666981 : Bak, Hansen, Henriksen, Hansen, Pakkenberg, Eiberg, Tommerup: Mutation analysis of the Sonic hedgehog promoter and putative enhancer elements in Parkinson's disease patients. in Brain research. Molecular brain research 2004 (PubMed)
    Show all 2 references for ABIN666981

  4. Human Sonic Hedgehog Protein expressed in Human Cells - ABIN2002696 : Stone, Hynes, Armanini, Swanson, Gu, Johnson, Scott, Pennica, Goddard, Phillips, Noll, Hooper, de Sauvage, Rosenthal: The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. in Nature 1996 (PubMed)
    Show all 2 references for ABIN2002696

  5. Mouse (Murine) Sonic Hedgehog Protein expressed in Human Cells - ABIN2008611 : Ericson, Briscoe, Rashbass, van Heyningen, Jessell: Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube. in Cold Spring Harbor symposia on quantitative biology 1998 (PubMed)
    Show all 2 references for ABIN2008611

More Proteins for Sonic Hedgehog Interaction Partners

Mouse (Murine) Sonic Hedgehog (SHH) interaction partners

  1. Studied the effect of 7-dehydrocholesterol reductase (Dhcr7 (show DHCR7 Proteins)) and identified signal pathways involved in regulation of embryonic palatogenesis. Expression changes of Dhcr7 (show DHCR7 Proteins), Sonic Hedgehog (Shh), and bone morphogenetic protein-2 (Bmp2 (show BMP2 Proteins)) were measured by RT-PCR and WB after Dhcr7 (show DHCR7 Proteins) gene silencing and the addition of exogenous cholesterol.

  2. found that the SHH expression promoted the transition from hepatocellular adenoma to hepatocellular carcinoma

  3. Shh stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis.

  4. Results indicate that an aged-related delay of fracture healing may contribute to the unbalanced bone formation and resorption, regulated by hedgehog signaling.

  5. Shh promotes neurite outgrowth in primary cortical neurons at least partially through modulating BDNF (show BDNF Proteins) expression.

  6. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (show WNT2 Proteins) pathway, and inhibition of Smad2 (show SMAD2 Proteins)/3 signaling and Shh pathways.

  7. Chronic up-regulation of Shh had minimal effect on craniofacial shape and did not correct facial abnormalities in Ts65Dn;Ptch (show PTCH1 Proteins)(+/-) mice.

  8. Activating the Shh signaling rescues endothelial progenitor cell dysfunction and promotes diabetic neovascularization.

  9. When the Shh signaling inhibitor jervine was added to the culture medium for 24-96 h, the formation of lateral lingual swellings and subsequent epithelial invagination into the mesenchyme were impaired markedly, leading to a hypoplastic tongue

  10. Report exposes a novel role for Shh in regulating mitochondrial dynamics and rescue the metabolic profile of tumor cells through regulation of mitofusin 1 (show MFN1 Proteins) and 2.

Human Sonic Hedgehog (SHH) interaction partners

  1. The recurring expression of NF-kB, SHH, K-RAS (show HRAS Proteins), and PTX3 (show PITX3 Proteins) in vimentin (show VIM Proteins)- and CD44 (show CD44 Proteins)-positive breast cancer cells allows to speculate that breast cells acquire the ability to express these molecules in concomitance to EMT (show ITK Proteins) phenomenon.

  2. sHH signaling pathway is involved in pancreatic cancer pain, and pancreatic stellate cells play an essential role in the process greatly by inducing Nerve Growth Factors.

  3. Study demonstrated that SHH is overexpressed in gastric cancer and is associated with poor survival.

  4. Shh protein is upregulated in breast cancer. Expression of this protein was statistically correlated with age and malignant stage.

  5. The roles of the SHH pathway in the context of limb development.[ review]

  6. The serum levels of IHH (show IHH Proteins) and SHH were significantly higher in autistic subjects than those of control subjects. The findings support a correlation between SHH, IHH (show IHH Proteins) and BDNF (show BDNF Proteins) in autistic children, suggesting their pathological role in autism

  7. MAPK (show MAPK1 Proteins) and SHH pathways modulate type 3 deiodinase (show DIO3 Proteins) expression in papillary thyroid carcinoma

  8. during human brain development, Shh plays an important role in the specification of cortical progenitors

  9. The disruption of a novel limb cis (show CISH Proteins)-regulatory element of SHH is associated with autosomal dominant preaxial polydactyly-hypertrichosis in a large French pedigree.

  10. Results obtained from in vitro and in vivo studies demonstrate that Shh may function as an inducer of bladder cancer progression. Its expression correlates with advanced clinical stages and poor prognostic bladder cancer.

Xenopus laevis Sonic Hedgehog (SHH) interaction partners

  1. Data indicate that sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of the regenerate.

  2. Dzip1 (show DZIP1 Proteins)-dependent stabilization of Spop (show SPOP Proteins)/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Proteins)/Ci proteins in the Hh pathway.

  3. Notch (show NOTCH1 Proteins) signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline.

  4. These results indicate that electrical activity and second-messenger signaling mediate Shh action in embryonic spinal neurons.

  5. Connective tissue-specific expression of BMP-4 (show BMP4 Proteins) mRNA is up-regulated by sonic hedgehog.

  6. In an examination of signaling pathways in developing Xenopus lung, shh but not ihh (show IHH Proteins) was expressed in the very anterior part of early lung epithelium.

  7. Data propose that Shh serves as a ventral optic tract repellent that helps to define the caudal boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.

  8. The forebrain of Xenopus revealed a largely conserved pattern of Shh expression among tetrapods.

  9. Hedgehog regulates superficial slow muscle fibres in Xenopus and tetrapod trunk myogenesis

  10. Results suggest that 7-dehydrocholesterol reductase (show DHCR7 Proteins) and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos

Cow (Bovine) Sonic Hedgehog (SHH) interaction partners

  1. study shows evolutionary alteration of a Ptch1 (show PTCH1 Proteins) cis (show CISH Proteins)-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development

Zebrafish Sonic Hedgehog (SHH) interaction partners

  1. Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.

  2. Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis

  3. Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity.

  4. We further demonstrate that the elevated Hedgehog signaling in Sox11 (show SOX11 Proteins)-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 (show SOX11 Proteins) morphants.

  5. Pax6 (show PAX6 Proteins) has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates.

  6. Sulf1 (show SULF1 Proteins) triggers Shh signaling activity to establish and, later on, modify the spatial arrangement of gene expression in ventral neural progenitors

  7. These studies provide evidence that a signaling pathway involving agrin (show AGRN Proteins), Fgfs and Shh may be a critical target of ethanol exposure during zebrafish embryogenesis.

  8. heterozygote mutations in fgf8 (show FGF8 Proteins), shh or oep (show TDGF1 Proteins) lead to a reduced number of ascending dopaminergic neurons in zebrafish and may confer increased susceptibility to the Parkinson disease

  9. Hh is able to bypass VEGF to induce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surprising complexity in the interplay between Hh and VEGF signaling during arteriovenous specification.

  10. The Sphingosine-1-phospate-dependent anterior foregut endoderm functions primarily through Shh to regulate the growth but not dorsoventral patterning of zebrafish jaw precursors.

Sonic Hedgehog (SHH) Protein Profile

Protein Summary

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

Alternative names and synonyms associated with Sonic Hedgehog (SHH)

  • sonic hedgehog (shh)
  • sonic hedgehog (SHH)
  • sonic hedgehog (LOC100352774)
  • sonic hedgehog (Shh)
  • sonic hedgehog a (shha)
  • 9530036O11Rik protein
  • Dsh protein
  • fc83d08 protein
  • hedgehog protein
  • HHG1 protein
  • HLP3 protein
  • HPE3 protein
  • Hx protein
  • Hxl3 protein
  • M100081 protein
  • MCOPCB5 protein
  • SHH protein
  • SMMCI protein
  • syu protein
  • TPT protein
  • TPTPS protein
  • vhh-1 protein
  • vhh1 protein
  • wu:fc83d08 protein
  • Xhh protein
  • xshh protein

Protein level used designations for Sonic Hedgehog Proteins (SHH)

sonic hedgehog protein , sonic hedgehog , HHG-1 , hemimelic extra toes , short digits , sonic hedgehog homolog , VHH-1 , X-SHH , morphogen , sonic hedgehog protein A , sonic-you

446055 Takifugu rubripes
100049186 Oryzias latipes
100136227 Oncorhynchus mykiss
100169727 Felis catus
100352774 Oryctolagus cuniculus
100505407 Sus scrofa
20423 Mus musculus
6469 Homo sapiens
398047 Xenopus laevis
395615 Gallus gallus
608860 Canis lupus familiaris
29499 Rattus norvegicus
286821 Bos taurus
30269 Danio rerio
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