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Browse our Sonic Hedgehog Proteins (SHH)

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Sonic Hedgehog Proteins (SHH)
On are 87 Sonic Hedgehog (SHH) Proteins from 17 different suppliers available. Additionally we are shipping Sonic Hedgehog Antibodies (138) and Sonic Hedgehog Kits (25) and many more products for this protein. A total of 259 Sonic Hedgehog products are currently listed.
9530036O11Rik, Dsh, fc83d08, hedgehog, HHG1, HLP3, HPE3, Hx, Hxl3, M100081, MCOPCB5, SHH, SMMCI, syu, TPT, TPTPS, vhh-1, vhh1, wu:fc83d08, Xhh, xshh
list all proteins Gene Name GeneID UniProt
SHH 20423 Q62226
SHH 6469 Q15465
SHH 29499 Q63673

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Sonic Hedgehog Proteins (SHH) by Origin

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Top referenced Sonic Hedgehog Proteins

  1. Human Sonic Hedgehog Protein expressed in Escherichia coli (E. coli) - ABIN2666482 : Ingham, McMahon: Hedgehog signaling in animal development: paradigms and principles. in Genes & development 2001 (PubMed)
    Show all 5 references for ABIN2666482

  2. Human Sonic Hedgehog Protein expressed in HEK-293 Cells - ABIN2181760 : Pepinsky, Zeng, Wen, Rayhorn, Baker, Williams, Bixler, Ambrose, Garber, Miatkowski, Taylor, Wang, Galdes: Identification of a palmitic acid-modified form of human Sonic hedgehog. in The Journal of biological chemistry 1998 (PubMed)
    Show all 2 references for ABIN2181760

  3. Human Sonic Hedgehog Protein expressed in Human Cells - ABIN2002696 : Stone, Hynes, Armanini, Swanson, Gu, Johnson, Scott, Pennica, Goddard, Phillips, Noll, Hooper, de Sauvage, Rosenthal: The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. in Nature 1996 (PubMed)
    Show all 2 references for ABIN2002696

  4. Human Sonic Hedgehog Protein expressed in Human Cells - ABIN2002699 : Ericson, Briscoe, Rashbass, van Heyningen, Jessell: Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube. in Cold Spring Harbor symposia on quantitative biology 1998 (PubMed)
    Show all 2 references for ABIN2002699

More Proteins for Sonic Hedgehog Interaction Partners

Mouse (Murine) Sonic Hedgehog (SHH) interaction partners

  1. Sufu (show SUFUH Proteins) is upregulated in active Shh responding tissues and accompanies Gli (show GLI1 Proteins) activators translocating into and Gli (show GLI1 Proteins) repressors out of the nucleus.

  2. Tbx2 (show TBX2 Proteins) and Tbx3 (show TBX3 Proteins) function downstream of Shh to maintain pro-proliferative mesenchymal Wnt (show WNT2 Proteins) signaling.

  3. cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH signaling through regulation of GLI3 (show GLI3 Proteins) processing.

  4. Activated microglia are major cell type for SHH expression in vivo and in vitro.

  5. these results reveal a novel role for E177-Zn(2+) in regulating SHH signaling that may involve critical, cilia basal-body localized changes in cross-linking and/or conformation.

  6. hair follicle transit-amplifying cells (HF-TACs) play an essential role in orchestrating dermal adipogenesis through secreting Sonic Hedgehog

  7. Shh acts as an endogenous mediator of mechanical stimuli on bone marrow stromal cells. Shh expression is regulated by DNA methylation (show HELLS Proteins).

  8. These data reveal an interaction between the cytoplasmic domains of Ptch1 (show PTCH1 Proteins) and that these domains modulate Ptch1 (show PTCH1 Proteins) activity but are not essential for regulation of the Hh pathway.

  9. These results indicate that the modulatory effects of SHH on BALB/c mouse metanephric explant cultures may involve the regulation of Fgf8 (show FGF8 Proteins) expression but not Fgf10 (show FGF10 Proteins) expression, which provides evidence for the functional role of Fgf proteins in renal morphogenesis.

  10. Wnt (show WNT2 Proteins), Eda (show EDA Proteins), and Shh have roles in touch dome Merkel cell development

Human Sonic Hedgehog (SHH) interaction partners

  1. Data indicate that agedunin induces its anti-metastatic effect through inhibition of sonic hedgehog protein [SHH] signaling.

  2. findings suggest that Usp7 (show USP7 Proteins) is important for MB cell proliferation and metastasis by activating Shh pathway, and is a putative therapeutic target for MBs (show PPP1R12A Proteins)

  3. importance of MAOA (show MAOA Proteins) for initiating the pre-metastatic niche in stromal cells and promoting PCa (show FLVCR1 Proteins) metastasis to bone and visceral organs, mediated by activation of paracrine Shh-IL6 (show IL6 Proteins)-RANKL (show TNFSF11 Proteins) signaling underlying tumor-stromal interactions.

  4. Studies indicate that sonic hedgehog protein (Shh) is upregulated specifically in renal tubular epithelium.

  5. these results reveal a novel role for E177-Zn(2+) in regulating SHH signaling that may involve critical, cilia basal-body localized changes in cross-linking and/or conformation.

  6. first report of the assessment of the frequency of GLI3 (show GLI3 Proteins)/SHH/preZRS/ZRS in Chinese polydactyly patients to show any higher possibility of mutations or variants for the 4 genes or sequences in China

  7. These data reveal an interaction between the cytoplasmic domains of Ptch1 (show PTCH1 Proteins) and that these domains modulate Ptch1 (show PTCH1 Proteins) activity but are not essential for regulation of the Hh pathway.

  8. SHH acted exclusively in a paracrine fashion on pancreatic stellate cells and influenced the growth of Pancreatic Cancer cells only indirectly, ADM (show ADM Proteins) could directly impact the growth of both Pancreatic Cancer cells and pancreatic stellate cells .

  9. data implicate perturbation of the Shh pathway in at least 37% of individuals with the hypothalamic hamartoma epilepsy syndrome, consistent with the concept of a developmental pathway brain disease

  10. The results suggested that, when the rs61730970, rs200798148 and rs146535482 alleles of the Hedgehog gene lacked particular single nucleotide polymorphisms, the patients were associated with a greater risk of Hirschsprung's disease and/or anorectal malformations [HSCR (show EDNRB Proteins): odds ratio (OR)=1.543, P=0.004; OR=1.494, P=0.007; rs146535482: OR=1.556, P=0.003, respectively.

Xenopus laevis Sonic Hedgehog (SHH) interaction partners

  1. Data indicate that sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of the regenerate.

  2. Dzip1 (show DZIP1 Proteins)-dependent stabilization of Spop (show SPOP Proteins)/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Proteins)/Ci proteins in the Hh pathway.

  3. Notch (show NOTCH1 Proteins) signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline.

  4. These results indicate that electrical activity and second-messenger signaling mediate Shh action in embryonic spinal neurons.

  5. Connective tissue-specific expression of BMP-4 (show BMP4 Proteins) mRNA is up-regulated by sonic hedgehog.

  6. In an examination of signaling pathways in developing Xenopus lung, shh but not ihh (show IHH Proteins) was expressed in the very anterior part of early lung epithelium.

  7. Data propose that Shh serves as a ventral optic tract repellent that helps to define the caudal boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.

  8. The forebrain of Xenopus revealed a largely conserved pattern of Shh expression among tetrapods.

  9. Hedgehog regulates superficial slow muscle fibres in Xenopus and tetrapod trunk myogenesis

  10. Results suggest that 7-dehydrocholesterol reductase (show DHCR7 Proteins) and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos

Cow (Bovine) Sonic Hedgehog (SHH) interaction partners

  1. study shows evolutionary alteration of a Ptch1 (show PTCH1 Proteins) cis (show CISH Proteins)-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development

Zebrafish Sonic Hedgehog (SHH) interaction partners

  1. Shh is not essential for the early activation of has2 (show HAS2 Proteins), but supports proper chondrogenic differentiation.

  2. Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.

  3. Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis

  4. Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity.

  5. We further demonstrate that the elevated Hedgehog signaling in Sox11 (show SOX11 Proteins)-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 (show SOX11 Proteins) morphants.

  6. Pax6 (show PAX6 Proteins) has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates.

  7. Sulf1 (show SULF1 Proteins) triggers Shh signaling activity to establish and, later on, modify the spatial arrangement of gene expression in ventral neural progenitors

  8. These studies provide evidence that a signaling pathway involving agrin (show AGRN Proteins), Fgfs and Shh may be a critical target of ethanol exposure during zebrafish embryogenesis.

  9. heterozygote mutations in fgf8 (show FGF8 Proteins), shh or oep (show TDGF1 Proteins) lead to a reduced number of ascending dopaminergic neurons in zebrafish and may confer increased susceptibility to the Parkinson disease

  10. Hh is able to bypass VEGF to induce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surprising complexity in the interplay between Hh and VEGF signaling during arteriovenous specification.

Sonic Hedgehog (SHH) Protein Profile

Protein Summary

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

Alternative names and synonyms associated with Sonic Hedgehog (SHH)

  • sonic hedgehog (shh)
  • sonic hedgehog (SHH)
  • sonic hedgehog (LOC100352774)
  • sonic hedgehog (Shh)
  • sonic hedgehog a (shha)
  • 9530036O11Rik protein
  • Dsh protein
  • fc83d08 protein
  • hedgehog protein
  • HHG1 protein
  • HLP3 protein
  • HPE3 protein
  • Hx protein
  • Hxl3 protein
  • M100081 protein
  • MCOPCB5 protein
  • SHH protein
  • SMMCI protein
  • syu protein
  • TPT protein
  • TPTPS protein
  • vhh-1 protein
  • vhh1 protein
  • wu:fc83d08 protein
  • Xhh protein
  • xshh protein

Protein level used designations for Sonic Hedgehog Proteins (SHH)

sonic hedgehog protein , sonic hedgehog , HHG-1 , hemimelic extra toes , short digits , sonic hedgehog homolog , VHH-1 , X-SHH , morphogen , sonic hedgehog protein A , sonic-you

446055 Takifugu rubripes
100049186 Oryzias latipes
100136227 Oncorhynchus mykiss
100169727 Felis catus
100352774 Oryctolagus cuniculus
100505407 Sus scrofa
20423 Mus musculus
6469 Homo sapiens
398047 Xenopus laevis
395615 Gallus gallus
608860 Canis lupus familiaris
29499 Rattus norvegicus
286821 Bos taurus
30269 Danio rerio
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