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Browse our Sonic Hedgehog Proteins (SHH)

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Sonic Hedgehog Proteins (SHH)
On are 88 Sonic Hedgehog (SHH) Proteins from 18 different suppliers available. Additionally we are shipping Sonic Hedgehog Antibodies (117) and Sonic Hedgehog Kits (23) and many more products for this protein. A total of 237 Sonic Hedgehog products are currently listed.
9530036O11Rik, Dsh, fc83d08, hedgehog, HHG1, HLP3, HPE3, Hx, Hxl3, M100081, MCOPCB5, SHH, SMMCI, syu, TPT, TPTPS, vhh-1, vhh1, wu:fc83d08, Xhh, xshh
list all proteins Gene Name GeneID UniProt
SHH 20423 Q62226
SHH 6469 Q15465
SHH 29499 Q63673

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Sonic Hedgehog Proteins (SHH) by Origin

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Top referenced Sonic Hedgehog Proteins

  1. Human Sonic Hedgehog Protein expressed in Escherichia coli (E. coli) - ABIN2666482 : Ingham, McMahon: Hedgehog signaling in animal development: paradigms and principles. in Genes & development 2001 (PubMed)
    Show all 5 references for ABIN2666482

  2. Human Sonic Hedgehog Protein expressed in HEK-293 Cells - ABIN2181760 : Pepinsky, Zeng, Wen, Rayhorn, Baker, Williams, Bixler, Ambrose, Garber, Miatkowski, Taylor, Wang, Galdes: Identification of a palmitic acid-modified form of human Sonic hedgehog. in The Journal of biological chemistry 1998 (PubMed)
    Show all 2 references for ABIN2181760

  3. Human Sonic Hedgehog Protein expressed in Escherichia coli (E. coli) - ABIN666981 : Bak, Hansen, Henriksen, Hansen, Pakkenberg, Eiberg, Tommerup: Mutation analysis of the Sonic hedgehog promoter and putative enhancer elements in Parkinson's disease patients. in Brain research. Molecular brain research 2004 (PubMed)
    Show all 2 references for ABIN666981

  4. Human Sonic Hedgehog Protein expressed in Human Cells - ABIN2002696 : Stone, Hynes, Armanini, Swanson, Gu, Johnson, Scott, Pennica, Goddard, Phillips, Noll, Hooper, de Sauvage, Rosenthal: The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. in Nature 1996 (PubMed)
    Show all 2 references for ABIN2002696

  5. Mouse (Murine) Sonic Hedgehog Protein expressed in Human Cells - ABIN2008611 : Ericson, Briscoe, Rashbass, van Heyningen, Jessell: Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube. in Cold Spring Harbor symposia on quantitative biology 1998 (PubMed)
    Show all 2 references for ABIN2008611

More Proteins for Sonic Hedgehog Interaction Partners

Mouse (Murine) Sonic Hedgehog (SHH) interaction partners

  1. Hedgehog regulates cerebellar progenitor cell and medulloblastoma apoptosis. Hedgehog's effects on apoptosis can occur independent of glucocorticoid stimulation.

  2. We proposed that LKB1 (show STK11 Proteins) regulates cerebellar development by controlling GCPs proliferation through Shh signalling during cerebellar development.

  3. Data show that the proliferation of sustained expression of Notch1 (show NOTCH1 Proteins)-induced choroid plexus (CP) tumours relies on Sonic Hedgehog (Shh) from the tumour microenvironment through their primary cilium.

  4. NANOG (show NANOG Proteins) binds to GLI1 (show GLI1 Proteins) and GLI3 (show GLI3 Proteins) proteins and represses Hedgehog-mediated transcription.

  5. Specific inactivation of Srg3 (show SMARCC1 Proteins) a core subunit of the remodeling complex, in developing limb buds hampered the transcriptional upregulation of Shh/Gli (show GLI1 Proteins) target genes, including the Shh receptor Ptch1 (show PTCH1 Proteins) and its downstream effector Gli1 (show GLI1 Proteins) in the posterior limb bud

  6. Loss of N-myc (show MYCN Proteins) significantly impairs the Sonic hedgehog signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (show CCND2 Proteins).

  7. Results suggest that amygdala neurogenesis and Shh signaling are involved in the extinction of fear memory

  8. Sufu (show SUFUH Proteins) deletion early in embryogenesis resulted in unstable Gli2 and Gli3 (show GLI3 Proteins) activity, leading to the ectopic activation of Shh signaling.

  9. Leptin (show LEP Proteins) upregulated Hedgehog signaling pathway in the process of adipocyte differentiation.

  10. The authors found that specific inhibition of Shh from hair follicles or from epithelial sources in general hindered development of Shh-responding dentate stem cells and that platelets contain epithelial Shh and provide Shh to the perinatal dentate gyrus.

Human Sonic Hedgehog (SHH) interaction partners

  1. The disruption of a novel limb cis (show CISH Proteins)-regulatory element of SHH is associated with autosomal dominant preaxial polydactyly-hypertrichosis in a large French pedigree.

  2. Results obtained from in vitro and in vivo studies demonstrate that Shh may function as an inducer of bladder cancer progression. Its expression correlates with advanced clinical stages and poor prognostic bladder cancer.

  3. The sonic hedgehog protein, through its receptors, plays a role in embryo development, in idiopathic pulmonary fibrosis, and in small cell lung carcinoma, non-small cell lung carcinoma and malignant pleural mesothelioma. Review.

  4. Crocetinic acid inhibited the expression of both Shh and smoothened in pancreatic cancer stem cells, thereby inhibiting pancreatic tumorigenesis

  5. hyperactivity of Hh signaling resulted in EGFR (show EGFR Proteins)-TKI resistance, by EMT (show ITK Proteins) introduction and ABCG2 upregulation, and blockade of Hh signaling synergistically increased sensitivity to EGFR (show EGFR Proteins)-TKIs in primary and secondary resistant NSCLC cells

  6. Increased SHH, PTCH (show PTCH1 Proteins), and GLI1 (show GLI1 Proteins) protein correlated positively with tumor grade, tumor depth and lymph node metastasis in Peutz-Jeghers syndrome.

  7. Data suggest that substrate specificity of hedgehog acyltransferase (HHAT (show HHAT Proteins)) in palmitoylation reaction extends to oligopeptide fragments of Sonic hedgehog protein (SHH).

  8. Data indicate that regulation of sonic hedgehog (SHh)-GLI family zinc finger 1 (Gli1 (show GLI1 Proteins)) signals to migration of pancreatic cancer AsPC-1 Cells through mediating eukaryotic translation initiation factor 5A (EIF5A2 (show EIF5A2 Proteins)) gene expression.

  9. appears to be responsive to the inhibition of GALNT1 (show Galnt1 Proteins) and SHH signaling

  10. Data suggest a role for hedgehog pathway (HhP) signaling in myeloid disease.

Xenopus laevis Sonic Hedgehog (SHH) interaction partners

  1. Data indicate that sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of the regenerate.

  2. Dzip1 (show DZIP1 Proteins)-dependent stabilization of Spop (show SPOP Proteins)/HIB is evolutionarily conserved and essential for proper regulation of Gli (show GLI1 Proteins)/Ci proteins in the Hh pathway.

  3. Notch (show NOTCH1 Proteins) signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline.

  4. These results indicate that electrical activity and second-messenger signaling mediate Shh action in embryonic spinal neurons.

  5. Connective tissue-specific expression of BMP-4 (show BMP4 Proteins) mRNA is up-regulated by sonic hedgehog.

  6. In an examination of signaling pathways in developing Xenopus lung, shh but not ihh (show IHH Proteins) was expressed in the very anterior part of early lung epithelium.

  7. Data propose that Shh serves as a ventral optic tract repellent that helps to define the caudal boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.

  8. The forebrain of Xenopus revealed a largely conserved pattern of Shh expression among tetrapods.

  9. Hedgehog regulates superficial slow muscle fibres in Xenopus and tetrapod trunk myogenesis

  10. Results suggest that 7-dehydrocholesterol reductase (show DHCR7 Proteins) and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos

Cow (Bovine) Sonic Hedgehog (SHH) interaction partners

  1. study shows evolutionary alteration of a Ptch1 (show PTCH1 Proteins) cis (show CISH Proteins)-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development

Zebrafish Sonic Hedgehog (SHH) interaction partners

  1. Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.

  2. Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis

  3. Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity.

  4. We further demonstrate that the elevated Hedgehog signaling in Sox11 (show SOX11 Proteins)-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 (show SOX11 Proteins) morphants.

  5. Pax6 (show PAX6 Proteins) has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates.

  6. Sulf1 (show SULF1 Proteins) triggers Shh signaling activity to establish and, later on, modify the spatial arrangement of gene expression in ventral neural progenitors

  7. These studies provide evidence that a signaling pathway involving agrin (show AGRN Proteins), Fgfs and Shh may be a critical target of ethanol exposure during zebrafish embryogenesis.

  8. heterozygote mutations in fgf8 (show FGF8 Proteins), shh or oep (show TDGF1 Proteins) lead to a reduced number of ascending dopaminergic neurons in zebrafish and may confer increased susceptibility to the Parkinson disease

  9. Hh is able to bypass VEGF to induce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surprising complexity in the interplay between Hh and VEGF signaling during arteriovenous specification.

  10. The Sphingosine-1-phospate-dependent anterior foregut endoderm functions primarily through Shh to regulate the growth but not dorsoventral patterning of zebrafish jaw precursors.

Sonic Hedgehog (SHH) Protein Profile

Protein Summary

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

Alternative names and synonyms associated with Sonic Hedgehog (SHH)

  • sonic hedgehog (shh)
  • sonic hedgehog (SHH)
  • sonic hedgehog (LOC100352774)
  • sonic hedgehog (Shh)
  • sonic hedgehog a (shha)
  • 9530036O11Rik protein
  • Dsh protein
  • fc83d08 protein
  • hedgehog protein
  • HHG1 protein
  • HLP3 protein
  • HPE3 protein
  • Hx protein
  • Hxl3 protein
  • M100081 protein
  • MCOPCB5 protein
  • SHH protein
  • SMMCI protein
  • syu protein
  • TPT protein
  • TPTPS protein
  • vhh-1 protein
  • vhh1 protein
  • wu:fc83d08 protein
  • Xhh protein
  • xshh protein

Protein level used designations for Sonic Hedgehog Proteins (SHH)

sonic hedgehog protein , sonic hedgehog , HHG-1 , hemimelic extra toes , short digits , sonic hedgehog homolog , VHH-1 , X-SHH , morphogen , sonic hedgehog protein A , sonic-you

446055 Takifugu rubripes
100049186 Oryzias latipes
100136227 Oncorhynchus mykiss
100169727 Felis catus
100352774 Oryctolagus cuniculus
100505407 Sus scrofa
20423 Mus musculus
6469 Homo sapiens
398047 Xenopus laevis
395615 Gallus gallus
608860 Canis lupus familiaris
29499 Rattus norvegicus
286821 Bos taurus
30269 Danio rerio
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