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SOX9 (show SOX9 Proteins) may promote cell growth by repressing the expression of CLDN8.
Findings suggest a new mechanistic pathway in inflammatory bowel disease in which MiR (show MLXIP Proteins)-223 functions as a proinflammatory molecule targeting CLDN8 in the IL23 (show IL23A Proteins) pathway.
High Claudin 8 Contributes to Malignant Proliferation in Osteosarcoma.
the expression of claudin-5 (show CLDN5 Proteins) and claudin-9 (show CLDN9 Proteins) was down-regulated while the expression of claudin-8 was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues.
Human Cldn-8 and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4 (show CLDN4 Proteins).
claudin-7 (show CLDN7 Proteins) and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma (show MOK Proteins) and oncocytoma
Na(+) absorption is paralleled by claudin-8-mediated sealing of the paracellular barrier to prevent Na(+) back-leakage, supporting steep Na(+) gradients in distal colon.
the combination of CK7 (show KRT7 Proteins), S100A1 (show S100A1 Proteins) and claudin 8 immunohistochemistry can be useful for classifying tumours of overlapping histology as chromophobe renal cell carcinoma (show MOK Proteins) or renal oncocytomas.
CLDN8, clustered with CLDN17 (show CLDN17 Proteins) at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.
We found that CLDN8 was expressed by both spermatogonia and a subset of Sertoli cells in the bovine testis.
KLHL3 (show KLHL3 Proteins) regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8
Claudin-8 is expressed at the variety of epithelial tissues in inner ear including stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area.
data show that claudin-4 (show CLDN4 Proteins) interacts with claudin-8 and that their association is required for the anion-selective paracellular pathway in the collecting duct
claudin-8 was found to be expressed primarily at the tight junction along the entire aldosterone-sensitive distal nephron and in the late segments of the thin descending limbs of long-looped nephrons
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.