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anti-Human FNDC5 Antibodies:
anti-Mouse (Murine) FNDC5 Antibodies:
anti-Rat (Rattus) FNDC5 Antibodies:
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Human Polyclonal FNDC5 Primary Antibody for IF (p), IHC (p) - ABIN1387505
Park, Kim, Choi, Heo, Park: New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro. in Cellular signalling 2015
Human Polyclonal FNDC5 Primary Antibody for IHC, IHC (p) - ABIN4327646
Komolka, Albrecht, Schering, Brenmoehl, Hoeflich, Maak: Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle? in PLoS ONE 2014
Human Polyclonal FNDC5 Primary Antibody for WB - ABIN1169430
Wrann, White, Salogiannnis, Laznik-Bogoslavski, Wu, Ma, Lin, Greenberg, Spiegelman: Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. in Cell metabolism 2013
Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
Irisin regulates the number and function of endothelial progenitor cells via the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/eNOS (show NOS3 Antibodies) pathway in mouse model of diabetes mellitus.
there is a correlation between sport performance, insulin (show INS Antibodies) sensitivity, and irisin levels
results firstly revealed that irisin mitigated oxygen-glucose deprivation-induced neuronal injury in part via inhibiting ROS (show ROS1 Antibodies)-NLRP3 (show NLRP3 Antibodies) inflammatory signaling pathway, suggesting a likely mechanism for irisin-induced therapeutic effect in ischemic stroke.
These data indicate that increased irisin levels may have protective roles in liver cancer cells through partial activation of the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway, which may facilitate liver cancer progression and decrease the sensitivity to chemotherapy.
Decreased serum irisin levels are related to emphysema in patients with COPD (show ARCN1 Antibodies) and involved in epithelial apoptosis, resulting in emphysema.
Irisin levels are lower in MI and CAD (show CAD Antibodies) implying that their production may depend on myocardial blood supply.
findings suggest that irisin plays an important role in metabolic disorders and may be affected by physiopathological status.
The FNDC5 rs3480 variant is associated with protection from clinically significant (show TSC2 Antibodies) fibrosis in patients with NAFLD, while irisin expression is correlated with the severity of NAFLD and may be involved in extracellular matrix deposition. These data suggest that irisin is involved in regulation of hepatic fibrogenesis.
The median irisin levels were determined higher in T1DM group compared to the control one.
The modulation of body composition and muscle strength induced by 16-week of resistance training in older women with and without obesity is not associated with changes in circulating Irisin levels.
Irisin is upregulated in a murine model of fibrosis, but not in experimental NAFLD (show TSC2 Antibodies) without significant fibrosis.
Irisin improved endothelial function by modulating HO-1 (show HMOX1 Antibodies)/ adiponectin (show ADIPOQ Antibodies) axis in perivascular adipose tissue (PVAT) in HFD-induced obese mice. These findings suggest that regulating PVAT function may be a potential mechanism by which irisin improves endothelial function in obesity.
results are the first to demonstrate that the protective effects of irisin in cardiomyoblasts exposed to hypoxia/reoxygenation might be associated with HDAC4 (show HDAC5 Antibodies) degradation.
The results indicate that FNDC5 deficiency impairs autophagy and FAO and enhances lipogenesis via the AMPK (show PRKAA1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway. FNDC5 deficiency aggravates whereas FNDC5 overexpression prevents the HFD-induced hyperlipemia, hepatic lipid accumulation, and impaired FAO and autophagy in the liver.
This research is the first to show that irisin modulates macrophage activity by reducing reactive oxygen species (ROS (show ROS1 Antibodies)) overproduction, which could suggest its potential anti-inflammatory properties.
No FNDC5 expression was detected in normal or cancerous stomach tissues. FNDC5 expression in white and brown adipose tissues in the cancer group increased compared with the control and non-cancer groups.
Report showed that irisin suppressed cholesterol synthesis in hepatocytes through the activation of 5' AMP-activated protein kinase (AMPK (show PRKAA2 Antibodies)) and subsequent inhibition of transcription and nuclear translocation of SREBP2 (show SREBF2 Antibodies).
PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. Review.
it is concluding that an enhanced expression of Fndc5 in neural progenitor cells is stimulated by Zfp521 (show ZNF521 Antibodies) overexpression in these cells
Irisin directly targets osteoblast, promoting osteoblast proliferation and differentiation via activating P38/ERK MAP kinase (show MAPK1 Antibodies) signaling cascades in vitro.
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein