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anti-Human FNDC5 Antibodies:
anti-Mouse (Murine) FNDC5 Antibodies:
anti-Rat (Rattus) FNDC5 Antibodies:
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Human Polyclonal FNDC5 Primary Antibody for FACS, IF (p) - ABIN1387505
Park, Kim, Choi, Heo, Park: New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro. in Cellular signalling 2015
Human Polyclonal FNDC5 Primary Antibody for WB - ABIN1169430
Wrann, White, Salogiannnis, Laznik-Bogoslavski, Wu, Ma, Lin, Greenberg, Spiegelman: Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. in Cell metabolism 2013
Human Polyclonal FNDC5 Primary Antibody for IHC, IHC (p) - ABIN4327646
Komolka, Albrecht, Schering, Brenmoehl, Hoeflich, Maak: Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle? in PLoS ONE 2014
Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
Results indicate that cytokines might predict irisin concentration in mothers and their offspring.
These findings suggest that IL-17A (show IL17A Antibodies) is an independent risk factor of non-proliferative diabetic retinopathy, and irisin could protect against diabetic retinopathy through potential anti-IL-17A (show IL17A Antibodies) effects.
All results indicated that irisin has protective effect on LPS (show IRF6 Antibodies)-induced ALI in mice and in A549 cells. Thus, irisn related with physical exercise may be a potential therapy for the treatment of pulmonary inflammation.
In the first trimester, irisin levels were significantly lower in women who later developed GDM (median = 453 ng/mL, range: 257-811 ng/mL) than in controls (median = 721 ng/mL, range: 700-786 ng/mL). In the second trimester, the difference in irisin levels between the GDM group (median = 749 ng/mL; range: 456-910 ng/mL) and controls (median = 757 ng/mL; range: 703-898 ng/mL) was not statistically significant.
increased irisin levels might contribute to altered energy metabolism in hyperthyroidism
meta-analysis. Circulating irisin is directly and positively associated with insulin (show INS Antibodies) resistance in non-diabetic adults.
irisin is not associated with depressiveness, anxiety and perceived stress in female obese patients.
serum irisin concentrations were negatively correlated with coronary atherosclerosis index in coronary artery disease patients.
serum irisin levels are related to visceral adiposity in non-diabetic hemodialysis patients
there is a significant association between circulating irisin and a favourable lipid profile in the general population, suggesting a role in reduced risk for non-communicable diseases
results are the first to demonstrate that the protective effects of irisin in cardiomyoblasts exposed to hypoxia/reoxygenation might be associated with HDAC4 (show HDAC5 Antibodies) degradation.
The results indicate that FNDC5 deficiency impairs autophagy and FAO and enhances lipogenesis via the AMPK (show PRKAA1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway. FNDC5 deficiency aggravates whereas FNDC5 overexpression prevents the HFD-induced hyperlipemia, hepatic lipid accumulation, and impaired FAO and autophagy in the liver.
This research is the first to show that irisin modulates macrophage activity by reducing reactive oxygen species (ROS (show ROS1 Antibodies)) overproduction, which could suggest its potential anti-inflammatory properties.
No FNDC5 expression was detected in normal or cancerous stomach tissues. FNDC5 expression in white and brown adipose tissues in the cancer group increased compared with the control and non-cancer groups.
Report showed that irisin suppressed cholesterol synthesis in hepatocytes through the activation of 5' AMP-activated protein kinase (AMPK (show PRKAA2 Antibodies)) and subsequent inhibition of transcription and nuclear translocation of SREBP2 (show SREBF2 Antibodies).
PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. Review.
it is concluding that an enhanced expression of Fndc5 in neural progenitor cells is stimulated by Zfp521 (show ZNF521 Antibodies) overexpression in these cells
Irisin directly targets osteoblast, promoting osteoblast proliferation and differentiation via activating P38/ERK MAP kinase (show MAPK1 Antibodies) signaling cascades in vitro.
irisin does not function through inflammatory NFKB activation like other myokines (such as TNFalpha (show TNF Antibodies)).
Muscle FNDC5 mRNA expression and irisin release are not IL-15 (show IL15 Antibodies)-dependent in mice.
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein