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anti-Human FNDC5 Antibodies:
anti-Mouse (Murine) FNDC5 Antibodies:
anti-Rat (Rattus) FNDC5 Antibodies:
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Human Polyclonal FNDC5 Primary Antibody for IF (p), IHC (p) - ABIN1387505
Park, Kim, Choi, Heo, Park: New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro. in Cellular signalling 2015
Human Polyclonal FNDC5 Primary Antibody for WB - ABIN1169430
Wrann, White, Salogiannnis, Laznik-Bogoslavski, Wu, Ma, Lin, Greenberg, Spiegelman: Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. in Cell metabolism 2013
Human Polyclonal FNDC5 Primary Antibody for IHC, IHC (p) - ABIN4327646
Komolka, Albrecht, Schering, Brenmoehl, Hoeflich, Maak: Locus characterization and gene expression of bovine FNDC5: is the myokine irisin relevant in cattle? in PLoS ONE 2014
Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
Low Circulating Irisin Levels are associated with Insulin (show INS Antibodies) Resistance and Oxidative Stress in Obese Women.
Circulating levels of irisin were increased by 8 weeks of resistance training in overweight/obese adults.
Low Circulating Irisin Levels are associated with Diabetes Mellitus.
Increased irisin immunoreactivity in tissues obtained from breast, ovary, cervix carcinomas, and endometrial hyperplasia suggest critical role of this peptide during carcinogenesis.
Behcet's disease (BD) is characterized by chronic inflammation, and low serum irisin levels in BD may be related to atherosclerosis.
Circulating irisin levels are associated with a beneficial metabolic profile but not with other adipokines and not with rs726344 in our cohort. Our data suggest a potential favorable role of irisin in the regulation of metabolism.
Recent findings on the PGC1alpha/FNDC5/BDNF pathway and its role in neuroprotection, and the controversial promise of the FNDC5 peptide irisin as a mediator of the positive benefits of exercise are discussed. Review.
Association between FNDC5 genetic variants and proliferative diabetic retinopathy
Single nucleotide polymorphisms in FNDC5 gene correlates with obesity and glucose-lipid metabolism in Saudi population.
Our results suggest that serum levels of myostatin (show MSTN Antibodies) and irisin are related in patients with type 2 diabetes
Report showed that irisin suppressed cholesterol synthesis in hepatocytes through the activation of 5' AMP-activated protein kinase (AMPK (show PRKAA2 Antibodies)) and subsequent inhibition of transcription and nuclear translocation of SREBP2 (show SREBF2 Antibodies).
PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. Review.
it is concluding that an enhanced expression of Fndc5 in neural progenitor cells is stimulated by Zfp521 (show ZNF521 Antibodies) overexpression in these cells
Irisin directly targets osteoblast, promoting osteoblast proliferation and differentiation via activating P38/ERK MAP kinase (show MAPK1 Antibodies) signaling cascades in vitro.
irisin does not function through inflammatory NFKB activation like other myokines (such as TNFalpha (show TNF Antibodies)).
Muscle FNDC5 mRNA expression and irisin release are not IL-15 (show IL15 Antibodies)-dependent in mice.
irisin alleviates endothelial dysfunction in type 2 diabetes partially via reducing oxidative stresses through inhibiting signaling pathways suggesting that irisin may be a promising molecule for the treatment of vascular complications of diabetes.
HFD induced obese mice showed decreased irisin secretion from adipose tissues, which might contribute to muscle insulin (show INS Antibodies) resistance.
Our study also suggests the existence of irisin-specific receptor on the membrane of H9C2 cells. In conclusion, irisin in a certain concentration rage (show AGER Antibodies) increased myocardial cell metabolism, inhibited cell proliferation and promoted cell differentiation
In summary, these results suggested that the endothelium-dependent relaxation of irisin is mediated by the nitric oxide (NO)-guanosine 3', 5'-cyclic phosphate (cGMP)-dependent pathway.
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein