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Ovarian expression of relaxin-3a, d and f genes, and the relaxin-3 receptor gene Rxfp3 (show RXFP3 Proteins), was studied in Danio rerio.
pattern indicates both conserved and divergent expression features of the relaxin-3 gene among developing zebrafish
we report the expression pattern of the duplicated zebrafish rln3b gene and compare it to the previously analyszd spatial expression pattern of the rln3a gene
the relaxin-3 B-chain C-terminus changes from the original folding-back conformation to an extended conformation during binding with RXFP3 (show RXFP3 Proteins), to allow its B27Trp and B26Arg residues to interact with the Trp138 and Glu141 residues of RXFP3 (show RXFP3 Proteins), respectively.
In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting.
the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3 (show RXFP3 Proteins)
Relaxin-3 is a high-efficacy agonist at RXFP4 with a comparable signal transduction profile to INSL5 (show INSL5 Proteins).
Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour.
Review of research depicts the connection of relaxin-3 with phenomena such as feeding behavior, spatial memory, sleep/wake cycle or modulation of pituitary gland hormone secretion.
we demonstrated distinct patterns of signalling for H3 and H2 relaxin and R3(BDelta23-27)R/I5 at the RXFP3 (show RXFP3 Proteins) receptor
Glu141 and Asp145 of the RXFP3 (show RXFP3 Proteins) interact with the highly conserved arginine residues of relaxin-3.
Mutant relaxin-3 shows a significant decrease in receptor-activation potency towards RXFP4.
Relaxin-2 (show RLN1 Proteins) or relaxin-3 levels are not related to component traits in patients with diabetes.
Results indicate endogenous RLN3/RXFP3 (show RXFP3 Proteins) signaling can modulate hippocampal-dependent spatial reference and working memory via effects on somatostatin (show SST Proteins) interneurons, and further our knowledge of hippocampal cognitive processing
That endogenous relaxin-3-RXFP3 (show RXFP3 Proteins) signalling is a powerful mediator of salt appetite in mice.
The present study compared the ability of relaxin-3 deficient (null mutation) and C57BL/6J wildtype littermate mice to entrain daily running wheel activity to timed food availability.
These findings are consistent with an earlier report of increased activity scores in rats acutely injected centrally with R3/I5, and further suggest a role for relaxin-3/RXFP3 (show RXFP3 Proteins) signalling in promoting behavioural arousal.
These preliminary studies suggest an interaction between relaxin-3 and ventrolateral preoptic galanin (show GAL Proteins) neurons that may contribute to the arousal-promoting action of relaxin-3.
Central injection of the RXFP3 agonists R3/I5 or H3 relaxin (0.5 nmol, icv) did not alter chow consumption in satiated mice relative to vehicle controls, during the 60 min after treatment.
Relaxin-3 knockout mice exhibit mild anxiolytic characteristics relative to wild-type mice, suggesting that this peptide is involved in anxiety-related behavior.
These studies support a role for relaxin-3 signaling in the control of arousal and sleep/wakefulness, and identify the relaxin-3 KO mouse as a useful model to study this role further.
Data provide evidence for the conserved nature of RLN3/RXFP3 (show RXFP3 Proteins) systems in mammalian brain and the ability of RLN3/RXFP3 (show RXFP3 Proteins) signaling to modulate "behavioral state" and an array of circuits involved in arousal, stress, affect, and cognition.
results indicate that relaxin 3 transcription is activated via the cAMP-PKA pathway in the downstream of CRF-R1 (show CRHR1 Proteins)
May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142).
relaxin-like peptide locus B
, relaxin 3
, relaxin family locus C type 2
, relaxin family locus C type I
, insulin-like 7
, insulin-like peptide 7
, insulin-like peptide INSL7
, prorelaxin H3
, prorelaxin M3
, prorelaxin R3
, Prorelaxin H3