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In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting.
Relaxin-2 (show RLN1 Proteins) significantly upregulated intracellular processes in human female ACL (show ACLY Proteins) cells, but no effect was observed in male cells. Relaxin increased MMP (MMP1 (show MMP1 Proteins) and MMP3 (show MMP3 Proteins)) and decreased alphaSMA (show ACTA2 Proteins) and type I and III collagen expression, which may act to alter the structural integrity of the ACL (show ACLY Proteins) tissue over time.
Data suggest that enhanced survival of normal prostate epithelial cells (PNT1A cell line) in presence of either or both angiotensin II (Ang II) and relaxin 2 (RLN2 (show RLN1 Proteins)) appears to be associated with increased ratio of BCL2 (show BCL2 Proteins)/BAX (show BAX Proteins) messenger RNA expression; thus, Ang II (show AGT Proteins) and/or RLN2 (show RLN1 Proteins) appear to be involved in regulation of apoptosis in prostate epithelium.
Relaxin in the hypothalamic paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins) pathway.
a novel fusion transcript comprising the RLN1 (show RLN1 Proteins) and RLN2 (show RLN1 Proteins) genes, was identified.
The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1 (show RXFP1 Proteins) has been deciphered.
Although serum relaxin level is not a causative factor for benign hypermobility syndrome, the significant increases in patients with hyperkyphosis and pes planus suggest the hypothesis that relaxin has a limited and indefinite role in patients with BJHS.
Relaxin Inhibits High Glucose-Induced Matrix Accumulation in Human Mesangial Cells by Interfering with TGFB1 (show TGFB1 Proteins) Production and Mesangial Cells Phenotypic Transition
the correlation between RLN2 and p-AKT or RLN2 and p-ERK1/2 expression was investigated.
Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour.
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants.
, prorelaxin H2
, relaxin, ovarian, of pregnancy
, relaxin 2
, relaxin 3-like protein c
, relaxin 3c
, relaxin family locus X