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Differential regulation in patients with LTP (show SCP2 Proteins)-induced anaphylaxis and those with NSAID-LTP (show SCP2 Proteins)-induced anaphylaxis of the IFN-gamma (show IFNG Proteins) pathway, IgG receptors, and ADORA3 might provide the pathogenic basis of their distinct responses
This study identifies human mast cell A3R as regulator of tissue remodeling gene expression in human mast cells and demonstrates a heretofore-unrecognized mode of feedback regulation that is exerted by this receptor.
This is a review of the role played by A2aR (show ADORA2A Proteins) and A3AR in regulating cancer pathogenesis, with a focus on melanoma, and the therapeutic potential of adenosine receptors pharmacological modulation. [review]
Different agonistic behavior at adenosine A3 receptor is linked to a sub-pocket of the binding site.
There is differential expression of receptors in rheumatoid synovial tissue such that ADORA3 is expressed at significantly higher levels
Data show that A2A and A3 adenosine receptor density inversely correlated with Disease Activity Score in 28 or 44 joints (DAS28 or DAS (show ube3a Proteins)) suggesting a direct role of the endogenous activation of these receptors in the control of RA joint inflammation.
adenosine stimulates human endothelial progenitor cells migration by activating AA and A receptors and provides evidence to support a role of adenosine in modulating angiogenic capacity of hEPC (show HAMP Proteins)
Inactivation of the ADORA3 receptor prevents the CXCL16 (show CXCL16 Proteins) effect of neuroprotection against excitotoxic damage.
single-nucleotide polymorphism (SNP) I248L (reference SNP ID: rs35511654) located in the A3R gene is associated with coronary heart disease
This study provides new insight into the spatial and temporal specificity of drug action that can be provided by allosteric modulation across a GPCR homodimeric interface.
A3AR knockout mice had higher survival rates following lethal doses of gamma-radiation than wild type mice.
Increased values of bone marrow parameters were found in femoral bone marrow from adenosine A3 receptor-knock out mice.
These studies reveal A3AR activation by adenosine as an endogenous anti-nociceptive pathway and support the development of A3AR agonists as novel therapeutics to treat chronic pain.
Adenosin inhibited Lipopolysaccharide-increased HIF1alpha (show HIF1A Proteins) accumulation under both normoxic and hypoxic conditions, through activation of A1 and A3 adenosine receptors.
A3AR induces reactive oxygen species generation, possibly through activation of Nox2 (show CYBB Proteins), with subsequent contraction of the mouse aorta.
A3 adenosine receptor inhibition improves the efficacy of hypertonic saline resuscitation.
Activation of A(1)R or A(3)R by CCPA or Cl-IB-MECA, respectively, protects cardiomyocytes from hypoxia via phosphorylation of p38 MAPK (show MAPK14 Proteins), which is located downstream from the mitochondrial K(ATP) channel opening
Activation of macrophages by lipopolysaccharide induced down-regulation of the expression of adenosine receptor A3 mrna.
Hematopoietic precursor cells expressed Adora3 mrna.
activation of the A(3)AR signals to suppress neutrophil functions by interfering with the monomeric GTPase (show RACGAP1 Proteins) Rac (show AKT1 Proteins), thus contributing to the ant-inflammatory actions of adenosine.
mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B Proteins)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B Proteins)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
adenosine A3 receptor
, adenosine receptor A3
, G-protein coupled receptor 2
, Gpcr 2
, A3 adenosine receptor